The Tyr-265-to-Cys mutator mutant of DNA polymerase beta induces a mutator phenotype in mouse LN12 cells.
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DNA polymerase family X: function, structure, and cellular rolesHuman DNA Polymerase Mutations Allowing Efficient Abasic Site BypassMutation of POLB causes lupus in miceMice reconstituted with DNA polymerase beta-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normallyDistinct function of conserved amino acids in the fingers of Saccharomyces cerevisiae DNA polymerase alpha.Mutational spectrum analysis of RNase H(35) deficient Saccharomyces cerevisiae using fluorescence-based directed termination PCR.A Change in the Rate-Determining Step of Polymerization by the K289M DNA Polymerase β Cancer-Associated VariantExpression of DNA polymerase {beta} cancer-associated variants in mouse cells results in cellular transformation.DNA pol λ's extraordinary ability to stabilize misaligned DNA.Loop II of DNA polymerase beta is important for polymerization activity and fidelity.Y265C DNA polymerase beta knockin mice survive past birth and accumulate base excision repair intermediate substrates.Base excision repair: contribution to tumorigenesis and target in anticancer treatment paradigmsThe I260Q variant of DNA polymerase beta extends mispaired primer termini due to its increased affinity for deoxynucleotide triphosphate substrates.A DNA polymerase beta mutant from colon cancer cells induces mutations.Cellular roles of DNA polymerase beta.Threonine 79 is a hinge residue that governs the fidelity of DNA polymerase beta by helping to position the DNA within the active site.Hinge residue I174 is critical for proper dNTP selection by DNA polymerase beta.DNA polymerase mu (Pol mu), homologous to TdT, could act as a DNA mutator in eukaryotic cells.Genome instability caused by a germline mutation in the human DNA repair gene POLB.Mismatched and matched dNTP incorporation by DNA polymerase beta proceed via analogous kinetic pathways.Genetic polymorphisms of XRCC1 and risk of the esophageal cancer.DNA Polymerase β Cancer-Associated Variant I260M Exhibits Nonspecific Selectivity toward the β-γ Bridging Group of the Incoming dNTP.Low fidelity DNA synthesis by human DNA polymerase-eta.I260Q DNA polymerase β highlights precatalytic conformational rearrangements critical for fidelity
P2860
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P2860
The Tyr-265-to-Cys mutator mutant of DNA polymerase beta induces a mutator phenotype in mouse LN12 cells.
description
1999 nî lūn-bûn
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1999年の論文
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1999年学术文章
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1999年学术文章
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1999年学术文章
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1999年学术文章
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1999年学术文章
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1999年學術文章
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1999年學術文章
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1999年學術文章
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name
The Tyr-265-to-Cys mutator mut ...... phenotype in mouse LN12 cells.
@ast
The Tyr-265-to-Cys mutator mut ...... phenotype in mouse LN12 cells.
@en
type
label
The Tyr-265-to-Cys mutator mut ...... phenotype in mouse LN12 cells.
@ast
The Tyr-265-to-Cys mutator mut ...... phenotype in mouse LN12 cells.
@en
prefLabel
The Tyr-265-to-Cys mutator mut ...... phenotype in mouse LN12 cells.
@ast
The Tyr-265-to-Cys mutator mut ...... phenotype in mouse LN12 cells.
@en
P2093
P2860
P356
P1476
The Tyr-265-to-Cys mutator mut ...... phenotype in mouse LN12 cells.
@en
P2093
C A Clairmont
J B Sweasy
L Narayanan
P M Glazer
P2860
P304
P356
10.1073/PNAS.96.17.9580
P407
P577
1999-08-01T00:00:00Z