PYK2 in osteoclasts is an adhesion kinase, localized in the sealing zone, activated by ligation of alpha(v)beta3 integrin, and phosphorylated by src kinase.
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Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motilityThe 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and functionCAS proteins in normal and pathological cell growth controlRegulation of the formation of osteoclastic actin rings by proline-rich tyrosine kinase 2 interacting with gelsolinImpaired differentiation of osteoclasts in TREM-2-deficient individualsRegulation of osteoclasts by membrane-derived lipid mediatorsPhosphatidylinositol 3,4,5-trisphosphate directs association of Src homology 2-containing signaling proteins with gelsolinPyk2 and Src mediate signaling to CCL18-induced breast cancer metastasisA Glanzmann's mutation in beta 3 integrin specifically impairs osteoclast functionSpatiotemporal regulation of Src and its substrates at invadosomesNon-overlapping functions for Pyk2 and FAK in osteoblasts during fluid shear stress-induced mechanotransductionProline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis.Regulation of podosome formation, microglial migration and invasion by Ca(2+)-signaling molecules expressed in podosomesThe proline-rich tyrosine kinase Pyk2 regulates platelet integrin αIIbβ3 outside-in signaling.Genetic evidence for a role for Src family kinases in TNF family receptor signaling and cell survival.Stable association of PYK2 and p130(Cas) in osteoclasts and their co-localization in the sealing zone.Regulation of osteoclast structure and function by FAK family kinasesBreaking new ground to build bonePyk2 activation triggers epidermal growth factor receptor signaling and cell motility after wounding sheets of epithelial cells.Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclastsOsteoclasts and odontoclasts: signaling pathways to development and disease.Regulation of sealing ring formation by L-plastin and cortactin in osteoclasts.Targeting Pyk2 for therapeutic interventionInvolvement of the orphan nuclear estrogen receptor-related receptor α in osteoclast adhesion and transmigration.Src inhibitors: genomics to therapeutics.Tyrosine phosphatase epsilon is a positive regulator of osteoclast function in vitro and in vivo.Calpain is required for normal osteoclast function and is down-regulated by calcitoninIntracellular membrane trafficking in bone resorbing osteoclasts.Extracellular ATP stimulates epithelial cell motility through Pyk2-mediated activation of the EGF receptorPyk2 is required for neutrophil degranulation and host defense responses to bacterial infection.Megakaryocytes regulate expression of Pyk2 isoforms and caspase-mediated cleavage of actin in osteoblasts.Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2(-/-) mice.Regulation of osteoclast function and bone mass by RAGE.IKK{beta} as a target for treatment of inflammation induced bone loss.Dynamic changes in the osteoclast cytoskeleton in response to growth factors and cell attachment are controlled by beta3 integrinDifferential expression of the FAK family kinases in rheumatoid arthritis and osteoarthritis synovial tissues.Pyk2 and Megakaryocytes Regulate Osteoblast Differentiation and Migration Via Distinct and Overlapping Mechanisms.Osteoprotegerin disrupts peripheral adhesive structures of osteoclasts by modulating Pyk2 and Src activities.Retromer in Osteoblasts Interacts With Protein Phosphatase 1 Regulator Subunit 14C, Terminates Parathyroid Hormone's Signaling, and Promotes Its Catabolic Response.Subcellular localization of proline-rich tyrosine kinase 2 during oocyte fertilization and early-embryo development in mice.
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PYK2 in osteoclasts is an adhesion kinase, localized in the sealing zone, activated by ligation of alpha(v)beta3 integrin, and phosphorylated by src kinase.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on September 1998
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
PYK2 in osteoclasts is an adhe ...... phosphorylated by src kinase.
@en
PYK2 in osteoclasts is an adhe ...... phosphorylated by src kinase.
@nl
type
label
PYK2 in osteoclasts is an adhe ...... phosphorylated by src kinase.
@en
PYK2 in osteoclasts is an adhe ...... phosphorylated by src kinase.
@nl
prefLabel
PYK2 in osteoclasts is an adhe ...... phosphorylated by src kinase.
@en
PYK2 in osteoclasts is an adhe ...... phosphorylated by src kinase.
@nl
P2093
P2860
P356
P1476
PYK2 in osteoclasts is an adhe ...... phosphorylated by src kinase.
@en
P2093
P2860
P304
P356
10.1172/JCI3212
P407
P577
1998-09-01T00:00:00Z