Upregulation of three Drosophila homologs of human chromosome 21 genes alters synaptic function: implications for Down syndrome.
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Down syndrome: searching for the genetic culpritsAnalysis of Amyloid Precursor Protein Function in Drosophila melanogasterWhere Environment Meets Cognition: A Focus on Two Developmental Intellectual Disability DisordersDissecting Alzheimer disease in Down syndrome using mouse modelsA genetic cause of Alzheimer disease: mechanistic insights from Down syndromeFrom Learning to Memory: What Flies Can Tell Us about Intellectual Disability TreatmentNebula/DSCR1 upregulation delays neurodegeneration and protects against APP-induced axonal transport defects by restoring calcineurin and GSK-3β signalingAberrant Expression of Histone Deacetylases 4 in Cognitive Disorders: Molecular Mechanisms and a Potential TargetDown Syndrome: Current Status, Challenges and Future PerspectivesTrisomy for synaptojanin1 in Down syndrome is functionally linked to the enlargement of early endosomesThe Sac domain-containing phosphoinositide phosphatases: structure, function, and diseaseMeeting at the crossroads: common mechanisms in Fragile X and Down syndromeActivity-dependent facilitation of Synaptojanin and synaptic vesicle recycling by the Minibrain kinaseA novel binding protein of single-minded 2: the mitotic arrest-deficient protein MAD2B.Pituitary Adenylate Cyclase-activating Polypeptide (PACAP) Targets Down Syndrome Candidate Region 1 (DSCR1/RCAN1) to control Neuronal Differentiation.Massively parallel sequencing reveals the complex structure of an irradiated human chromosome on a mouse background in the Tc1 model of Down syndrome.Alterations to dendritic spine morphology, but not dendrite patterning, of cortical projection neurons in Tc1 and Ts1Rhr mouse models of Down syndromeUbiquitin ligase HUWE1 regulates axon branching through the Wnt/β-catenin pathway in a Drosophila model for intellectual disability.Physiologic and anatomic characterization of the brain surface glia barrier of DrosophilaSynaptophysin and synaptojanin-1 in Down syndrome are differentially affected by Alzheimer's diseaseIncreased efficiency of the GABAA and GABAB receptor-mediated neurotransmission in the Ts65Dn mouse model of Down syndromeExploring the Phenotypic Space and the Evolutionary History of a Natural Mutation in Drosophila melanogaster.Intersectin 1 contributes to phenotypes in vivo: implications for Down's syndrome.Sparse reduced-rank regression detects genetic associations with voxel-wise longitudinal phenotypes in Alzheimer's disease.Down syndrome and the molecular pathogenesis resulting from trisomy of human chromosome 21.Intersectin: The Crossroad between Vesicle Exocytosis and Endocytosis.Allele-Specific Phenotype Suggests a Possible Stimulatory Activity of RCAN-1 on Calcineurin in Caenorhabditis elegans.Numb and Alzheimer's disease: the current pictureChronic high levels of the RCAN1-1 protein may promote neurodegeneration and Alzheimer disease.Aging and intellectual disability: insights from mouse models of Down syndrome.Intersectin-1s: an important regulator of cellular and molecular pathways in lung injury.Aberrant expression of RCAN1 in Alzheimer's pathogenesis: a new molecular mechanism and a novel drug target.The role of phosphoinositides in synapse function.Synaptojanin 1 mutation in Parkinson's disease brings further insight into the neuropathological mechanisms.A third copy of the Down syndrome cell adhesion molecule (Dscam) causes synaptic and locomotor dysfunction in Drosophila.RCAN1 in the inverse association between Alzheimer's disease and cancer.Defects in nerve conduction velocity and different muscle fibre-type specificity contribute to muscle weakness in Ts1Cje Down syndrome mouse model.
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Upregulation of three Drosophila homologs of human chromosome 21 genes alters synaptic function: implications for Down syndrome.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 21 September 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Upregulation of three Drosophi ...... mplications for Down syndrome.
@en
Upregulation of three Drosophi ...... mplications for Down syndrome.
@nl
type
label
Upregulation of three Drosophi ...... mplications for Down syndrome.
@en
Upregulation of three Drosophi ...... mplications for Down syndrome.
@nl
prefLabel
Upregulation of three Drosophi ...... mplications for Down syndrome.
@en
Upregulation of three Drosophi ...... mplications for Down syndrome.
@nl
P2860
P356
P1476
Upregulation of three Drosophi ...... implications for Down syndrome
@en
P2093
Karen T Chang
P2860
P304
17117-17122
P356
10.1073/PNAS.0904397106
P407
P577
2009-09-21T00:00:00Z