High throughput methods of assessing protein stability and aggregation.
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Identification of direct protein targets of small moleculesRecent developments in the use of differential scanning fluorometry in protein and small molecule discovery and characterizationCrystal Structure of the Human Ubiquitin-activating Enzyme 5 (UBA5) Bound to ATP: MECHANISTIC INSIGHTS INTO A MINIMALISTIC E1 ENZYMEEnzyme-substrate complex structures of CYP154C5 shed light on its mode of highly selective steroid hydroxylationIdentification and characterization of the first small molecule inhibitor of MDMXXylanase (GH11) from Acremonium cellulolyticus: homologous expression and characterizationStabilizing proteins from sequence statistics: the interplay of conservation and correlation in triosephosphate isomerase stability.Affinity-based screening techniques: their impact and benefit to increase the number of high quality leads.Development of a Thermofluor assay for stability determination of membrane proteins using the Na(+)/H(+) antiporter NhaA and cytochrome c oxidase.Human defensins facilitate local unfolding of thermodynamically unstable regions of bacterial protein toxins.Probing the kinetic stabilities of Friedreich's ataxia clinical variants using a solid phase GroEL chaperonin capture platform.Ligands for glaucoma-associated myocilin discovered by a generic binding assayIdentifying bottlenecks in transient and stable production of recombinant monoclonal-antibody sequence variants in Chinese hamster ovary cellsConformational stability and self-association equilibrium in biologicsChemical denaturation as a tool in the formulation optimization of biologics.Small-molecule inhibitor of the Shigella flexneri master virulence regulator VirF.Retrocyclins neutralize bacterial toxins by potentiating their unfolding.Protein stability by number: high-throughput and statistical approaches to one of protein science's most difficult problems.Stabilizing biocatalysts.A survey of proteins encoded by non-synonymous single nucleotide polymorphisms reveals a significant fraction with altered stability and activity.Quantitation of protein-protein interactions by thermal stability shift analysisBiophysics: for HTS hit validation, chemical lead optimization, and beyond.Application of the thermofluor PaSTRy technique for improving foot-and-mouth disease virus vaccine formulation.Use of thermal melt curves to assess the quality of enzyme preparationsThe type IV pilus assembly ATPase PilB functions as a signaling protein to regulate exopolysaccharide production in Myxococcus xanthus.C-terminal truncation of a bovine B(12) trafficking chaperone enhances the sensitivity of the glutathione-regulated thermostability.Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1)Development of self-assembling mixed protein micelles with temperature-modulated aviditiesNovel microscale approaches for easy, rapid determination of protein stability in academic and commercial settings.A hidden aggregation-prone structure in the heart of hypoxia inducible factor prolyl hydroxylase.Temperature stability of proteins: Analysis of irreversible denaturation using isothermal calorimetry.The Catalytic Inactivation of the N-half of Human Hexokinase 2 and Structural and Biochemical Characterization of its Mitochondrial Conformation.Sensitive Detection of Immunoglobulin G Stability Using in Real-Time Isothermal Differential Scanning Fluorimetry: Determinants of Protein Stability for Antibody-Based Therapeutics.Improved thermostability of a metagenomic glucose-tolerant β-glycosidase based on its X-ray crystal structure.Glutathione and vitamin B₁₂ cooperate in stabilization of a B₁₂ trafficking chaperone protein.Rapid determination of protein stability and ligand binding by differential scanning fluorimetry of GFP-tagged proteins
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High throughput methods of assessing protein stability and aggregation.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 24 December 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
High throughput methods of assessing protein stability and aggregation.
@en
High throughput methods of assessing protein stability and aggregation.
@nl
type
label
High throughput methods of assessing protein stability and aggregation.
@en
High throughput methods of assessing protein stability and aggregation.
@nl
prefLabel
High throughput methods of assessing protein stability and aggregation.
@en
High throughput methods of assessing protein stability and aggregation.
@nl
P2860
P356
P1433
P1476
High throughput methods of assessing protein stability and aggregation.
@en
P2093
Guillermo A Senisterra
Patrick J Finerty
P2860
P304
P356
10.1039/B814377C
P577
2008-12-24T00:00:00Z