The cochaperone BAG2 sweeps paired helical filament- insoluble tau from the microtubule.
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Exosomes: vehicles for the transfer of toxic proteins associated with neurodegenerative diseases?The miR-15/107 group of microRNA genes: evolutionary biology, cellular functions, and roles in human diseasesPaired helical filaments from Alzheimer disease brain induce intracellular accumulation of Tau protein in aggresomesTemperature and toxic Tau in Alzheimer's disease: new insightsEpigenetics of Aging and Alzheimer's Disease: Implications for Pharmacogenomics and Drug ResponseAmitriptyline-mediated cognitive enhancement in aged 3×Tg Alzheimer's disease mice is associated with neurogenesis and neurotrophic activityA novel, non-apoptotic role for Scythe/BAT3: a functional switch between the pro- and anti-proliferative roles of p21 during the cell cycleBinding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitroHeat shock protein 70 prevents both tau aggregation and the inhibitory effects of preexisting tau aggregates on fast axonal transport.BAG3 is involved in neuronal differentiation and migration.BAG2 structure, function and involvement in disease.MiR-124-3p attenuates hyperphosphorylation of Tau protein-induced apoptosis via caveolin-1-PI3K/Akt/GSK3β pathway in N2a/APP695swe cells.Phosphorylation of tau at Y18, but not tau-fyn binding, is required for tau to modulate NMDA receptor-dependent excitotoxicity in primary neuronal culture.Protein aggregation containing β-amyloid, α-synuclein and hyperphosphorylated τ in cultured cells of hippocampus, substantia nigra and locus coeruleus after rotenone exposure.Vulnerabilities in the tau network and the role of ultrasensitive points in tau pathophysiology.Ubiquitinylation of α-synuclein by carboxyl terminus Hsp70-interacting protein (CHIP) is regulated by Bcl-2-associated athanogene 5 (BAG5).RNA stores tau reversibly in complex coacervatesHeat shock protein 70 (hsp70) as an emerging drug target.A caspase cleaved form of tau is preferentially degraded through the autophagy pathway.The epigenetic dimension of Alzheimer's disease: causal, consequence, or curiosity?Impaired adaptive cellular responses to oxidative stress and the pathogenesis of Alzheimer's diseaseThe Hsp90 kinase co-chaperone Cdc37 regulates tau stability and phosphorylation dynamics.Axotrophin/MARCH7 acts as an E3 ubiquitin ligase and ubiquitinates tau protein in vitro impairing microtubule binding.Tumour necrosis factor-α (TNF-α) and miRNA expression in frontal and temporal neocortex in Alzheimer's disease and the effect of TNF-α on miRNA expression in vitroThe toxicity of tau in Alzheimer disease: turnover, targets and potential therapeuticsMolecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies.The Co-chaperone BAG2 Mediates Cold-Induced Accumulation of Phosphorylated Tau in SH-SY5Y Cells.Heat shock response and insulin-associated neurodegeneration.Crystallization and preliminary X-ray crystallographic analysis of the Bag2 amino-terminal domain from Mus musculusMicroRNAs and the Regulation of Tau MetabolismBAG2 promotes tumorigenesis through enhancing mutant p53 protein levels and function.Protective Effect of Tat PTD-Hsp27 Fusion Protein on Tau Hyperphosphorylation Induced by Okadaic Acid in the Human Neuroblastoma Cell Line SH-SY5Y.Potential contribution of exosomes to the prion-like propagation of lesions in Alzheimer's disease.Involvement of Bcl-2-associated athanogene (BAG)-family proteins in the neuroprotection by rasagiline.Reversal of neurofibrillary tangles and tau-associated phenotype in the rTgTauEC model of early Alzheimer's disease.Opposing actions of environmental enrichment and Alzheimer's disease on the expression of hippocampal microRNAs in mouse modelsCurcumin-induced upregulation of the anti-tau cochaperone BAG2 in primary rat cortical neuronsMicroRNA implications across neurodevelopment and neuropathology.Pharmacological targeting of the Hsp70 chaperone.Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52.
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The cochaperone BAG2 sweeps paired helical filament- insoluble tau from the microtubule.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on February 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The cochaperone BAG2 sweeps paired helical filament- insoluble tau from the microtubule.
@en
The cochaperone BAG2 sweeps paired helical filament- insoluble tau from the microtubule.
@nl
type
label
The cochaperone BAG2 sweeps paired helical filament- insoluble tau from the microtubule.
@en
The cochaperone BAG2 sweeps paired helical filament- insoluble tau from the microtubule.
@nl
prefLabel
The cochaperone BAG2 sweeps paired helical filament- insoluble tau from the microtubule.
@en
The cochaperone BAG2 sweeps paired helical filament- insoluble tau from the microtubule.
@nl
P2093
P2860
P1476
The cochaperone BAG2 sweeps paired helical filament- insoluble tau from the microtubule
@en
P2093
Israel Hernandez
Kenneth S Kosik
Thales Papagiannakopoulos
P2860
P304
P356
10.1523/JNEUROSCI.4660-08.2009
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P577
2009-02-01T00:00:00Z