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Crystal structure of the stress-inducible human heat shock protein 70 substrate-binding domain in complex with peptide substrateDirect and Propagated Effects of Small Molecules on Protein-Protein Interaction NetworksFeatures of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinityRole of redox signaling in neuroinflammation and neurodegenerative diseasesHeat shock transcription factor 1 as a therapeutic target in neurodegenerative diseasesMolecular mechanism of allosteric communication in Hsp70 revealed by molecular dynamics simulationsOverexpression, Purification and Characterisation of the Plasmodium falciparum Hsp70-z (PfHsp70-z) ProteinStructural basis for the inhibition of HSP70 and DnaK chaperones by small-molecule targeting of a C-terminal allosteric pocketAllostery in the Hsp70 chaperone proteinsIdentification of key hinge residues important for nucleotide-dependent allostery in E. coli Hsp70/DnaKDnaK as Antibiotic Target: Hot Spot Residues Analysis for Differential Inhibition of the Bacterial Protein in Comparison with the Human HSP70A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.Inhibitors of difficult protein-protein interactions identified by high-throughput screening of multiprotein complexes.The role of HTS in drug discovery at the University of Michigan.Binding of a small molecule at a protein-protein interface regulates the chaperone activity of hsp70-hsp40.Natural products as chemical probesChemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators.Heat shock protein 70 (hsp70) as an emerging drug target.Mutagenesis reveals the complex relationships between ATPase rate and the chaperone activities of Escherichia coli heat shock protein 70 (Hsp70/DnaK)Protein chaperones: a composition of matter review (2008 - 2013).The dyslexia candidate gene DYX1C1 is a potential marker of poor survival in breast cancer.Restoring HSP70 deficiencies improves glucose tolerance in diabetic monkeys.Proteome interrogation using nanoprobes to identify targets of a cancer-killing molecule.Proteomics: a strategy to understand the novel targets in protein misfolding and cancer therapy.Heme-dependent activation of neuronal nitric oxide synthase by cytosol is due to an Hsp70-dependent, thioredoxin-mediated thiol-disulfide interchange in the heme/substrate binding cleftAn RNA aptamer specific to Hsp70-ATP conformation inhibits its ATPase activity independent of Hsp40.Antimyeloma Effects of the Heat Shock Protein 70 Molecular Chaperone Inhibitor MAL3-101Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies.Heat shock protein 70 kDa chaperone/DnaJ cochaperone complex employs an unusual dynamic interface.Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression.Multi-layered molecular mechanisms of polypeptide holding, unfolding and disaggregation by HSP70/HSP110 chaperonesVisualization and functional analysis of the oligomeric states of Escherichia coli heat shock protein 70 (Hsp70/DnaK).A small molecule inhibitor for ATPase activity of Hsp70 and Hsc70 enhances the immune response to protein antigens.Cysteine reactivity distinguishes redox sensing by the heat-inducible and constitutive forms of heat shock protein 70Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradationAptamer-Enabled Manipulation of the Hsp70 Chaperone System Suggests a Novel Strategy for Targeted Ubiquitination.Heat shock protein 70 regulates platelet integrin activation, granule secretion and aggregation.Heat shock proteins in the retina: Focus on HSP70 and alpha crystallins in ganglion cell survival.The HSP70 family and cancerSynthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels.
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description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Pharmacological targeting of the Hsp70 chaperone.
@en
Pharmacological targeting of the Hsp70 chaperone.
@nl
type
label
Pharmacological targeting of the Hsp70 chaperone.
@en
Pharmacological targeting of the Hsp70 chaperone.
@nl
prefLabel
Pharmacological targeting of the Hsp70 chaperone.
@en
Pharmacological targeting of the Hsp70 chaperone.
@nl
P2093
P2860
P1476
Pharmacological targeting of the Hsp70 chaperone.
@en
P2093
Jason E Gestwicki
Srikanth Patury
Yoshinari Miyata
P2860
P304
P356
10.2174/156802609789895674
P577
2009-01-01T00:00:00Z