Computer analysis of retroviral pol genes: assignment of enzymatic functions to specific sequences and homologies with nonviral enzymes.
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Cloning of the cDNA encoding the large subunit of human RNase HI, a homologue of the prokaryotic RNase HIIEvolutionary relationships among group II intron-encoded proteins and identification of a conserved domain that may be related to maturase functionRNase H activity: structure, specificity, and function in reverse transcriptionLamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acidsCD8+ T lymphocyte responses target functionally important regions of Protease and Integrase in HIV-1 infected subjectsInfluence of the RNase H domain of retroviral reverse transcriptases on the metal specificity and substrate selection of their polymerase domainsCrystal structure of the HIV-1 integrase catalytic core and C-terminal domains: A model for viral DNA bindingPurification of Saccharomyces cerevisiae RNase H(70) and identification of the corresponding gene.Chimeric human immunodeficiency virus type 1/type 2 reverse transcriptases display reversed sensitivity to nonnucleoside analog inhibitorsNovel mutation in the human immunodeficiency virus type 1 reverse transcriptase gene that encodes cross-resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidineHuman immunodeficiency virus type 1 pol gene mutations which cause decreased susceptibility to 2',3'-dideoxycytidineMode of inhibition of HIV reverse transcriptase by 2-hexaprenylhydroquinone, a novel general inhibitor of RNA-and DNA-directed DNA polymerasesStructural and sequencing analysis of local target DNA recognition by MLV integrase.Dissecting the role of the N-terminal domain of human immunodeficiency virus integrase by trans-complementation analysisStructural determinants of metal-induced conformational changes in HIV-1 integrase.Peptides derived from the reverse transcriptase of human immunodeficiency virus type 1 as novel inhibitors of the viral integrase.Revealing domain structure through linker-scanning analysis of the murine leukemia virus (MuLV) RNase H and MuLV and human immunodeficiency virus type 1 integrase proteinsRetrotransposon-like nature of Tp1 elements: implications for the organisation of highly repetitive, hypermethylated DNA in the genome of Physarum polycephalum.Expression of soluble, enzymatically active, human immunodeficiency virus reverse transcriptase in Escherichia coli and analysis of mutants.Domain structure of the Moloney murine leukemia virus reverse transcriptase: mutational analysis and separate expression of the DNA polymerase and RNase H activities.Irreversible inhibition of human immunodeficiency virus type 1 integrase by dicaffeoylquinic acids.A chimeric Ty3/Moloney murine leukemia virus integrase protein is active in vivo.Mutations in the human immunodeficiency virus type 1 integrase D,D(35)E motif do not eliminate provirus formation.Cloning and expression of a human T-lymphotropic virus type 1 protein with reverse transcriptase activityGenetic analysis of the rat leukemia virus: influence of viral sequences in transduction of the c-ras proto-oncogene and expression of its transforming activityRetroviral DNA integration.Targeting human immunodeficiency virus (HIV) type 2 integrase protein into HIV type 1.Sequence and insertion sites of murine melanoma-associated retrovirus.Linker insertion mutagenesis of the human immunodeficiency virus reverse transcriptase expressed in bacteria: definition of the minimal polymerase domain.Critical contacts between HIV-1 integrase and viral DNA identified by structure-based analysis and photo-crosslinking.Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition.High sequence conservation of human immunodeficiency virus type 1 reverse transcriptase under drug pressure despite the continuous appearance of mutations.AIDS virus reverse transcriptase defined by high level expression in Escherichia coli.Genetic evidence for two protein domains and a potential new activity in bacteriophage T4 DNA polymeraseIdentification of discrete functional domains of HIV-1 integrase and their organization within an active multimeric complex.The application of a homologous recombination assay revealed amino acid residues in an LTR-retrotransposon that were critical for integration.Comparison of multiple molecular dynamics trajectories calculated for the drug-resistant HIV-1 integrase T66I/M154I catalytic domain.Large-scale conformational dynamics of the HIV-1 integrase core domain and its catalytic loop mutantsPlant retrotransposon from Lilium henryi is related to Ty3 of yeast and the gypsy group of Drosophila.A long interspersed repetitive element--the I factor of Drosophila teissieri--is able to transpose in different Drosophila species
P2860
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P2860
Computer analysis of retroviral pol genes: assignment of enzymatic functions to specific sequences and homologies with nonviral enzymes.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on October 1986
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Computer analysis of retrovira ...... ologies with nonviral enzymes.
@en
Computer analysis of retrovira ...... ologies with nonviral enzymes.
@nl
type
label
Computer analysis of retrovira ...... ologies with nonviral enzymes.
@en
Computer analysis of retrovira ...... ologies with nonviral enzymes.
@nl
prefLabel
Computer analysis of retrovira ...... ologies with nonviral enzymes.
@en
Computer analysis of retrovira ...... ologies with nonviral enzymes.
@nl
P2093
P2860
P356
P1476
Computer analysis of retrovira ...... ologies with nonviral enzymes.
@en
P2093
M A McClure
M S Johnson
R F Doolittle
P2860
P304
P356
10.1073/PNAS.83.20.7648
P407
P577
1986-10-01T00:00:00Z