T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity.
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Human cord blood stem cell-modulated regulatory T lymphocytes reverse the autoimmune-caused type 1 diabetes in nonobese diabetic (NOD) miceT cell recognition of weak ligands: roles of signaling, receptor number, and affinityIdentifying Individual T Cell Receptors of Optimal Avidity for Tumor AntigensLower Affinity T Cells are Critical Components and Active Participants of the Immune ResponseDeath-defining immune responses after apoptosisStructural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptorStructure of a TCR with high affinity for self-antigen reveals basis for escape from negative selectionMass Spectrometry of Human Leukocyte Antigen Class I Peptidomes Reveals Strong Effects of Protein Abundance and Turnover on Antigen PresentationBaculovirus-infected insect cells expressing peptide-MHC complexes elicit protective antitumor immunity.Avidity-dependent programming of autoreactive T cells in T1DGene expression profiling and real-time PCR analyses identify novel potential cancer-testis antigens in multiple myeloma.Antigen capture and archiving by lymphatic endothelial cells following vaccination or viral infectionManipulating antigenic ligand strength to selectively target myelin-reactive CD4+ T cells in EAE.HLA-E-restricted regulatory CD8(+) T cells are involved in development and control of human autoimmune type 1 diabetesTCR recognition of peptide/MHC class II complexes and superantigensProgression of relapsing-remitting demyelinating disease does not require increased TCR affinity or epitope spreadHigh prevalence of low affinity peptide-MHC II tetramer-negative effectors during polyclonal CD4+ T cell responsesTolerance is established in polyclonal CD4(+) T cells by distinct mechanisms, according to self-peptide expression patterns.Optimal T-cell receptor affinity for inducing autoimmunity.Potent Antitumor Activity Generated by a Novel Tumor Specific Cytotoxic T Cell.The self-obsession of T cells: how TCR signaling thresholds affect fate 'decisions' and effector function.T cell receptor cross-reactivity between similar foreign and self peptides influences naive cell population size and autoimmunity.Nondominant CD8 T cells are active players in the vaccine-induced antitumor immune response.Quantitative impact of thymic selection on Foxp3+ and Foxp3- subsets of self-peptide/MHC class II-specific CD4+ T cells.Altered differentiation, diminished pathogenicity, and regulatory activity of myelin-specific T cells expressing an enhanced affinity TCR.Clonal Deletion Prunes but Does Not Eliminate Self-Specific αβ CD8(+) T Lymphocytes.Conditional superagonist CTL ligands for the promotion of tumor-specific CTL responses.Prenatal Allospecific NK Cell Tolerance Hinges on Instructive Allorecognition through the Activating Receptor during Development.Danger-free autoimmune disease in Aire-deficient mice.A broad range of self-reactivity drives thymic regulatory T cell selection to limit responses to self.Autoreactive T cells bypass negative selection and respond to self-antigen stimulation during infection.Perceiving the avidity of T cell activation can be translated into peripheral T cell regulation.Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death.CD4+ T Cell Tolerance to Tissue-Restricted Self Antigens Is Mediated by Antigen-Specific Regulatory T Cells Rather Than Deletion.Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude.Selection of self-reactive T cells in the thymus.Mechanistic basis of immunotherapies for type 1 diabetes mellitusT-cell migration: a naive paradigm?Avidity maturation of memory CD8 T cells is limited by self-antigen expression.Mobilizing the low-avidity T cell repertoire to kill tumors.
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T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 03 August 2006
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
T cells with low avidity for a ...... erance and cause autoimmunity.
@en
T cells with low avidity for a ...... erance and cause autoimmunity.
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type
label
T cells with low avidity for a ...... erance and cause autoimmunity.
@en
T cells with low avidity for a ...... erance and cause autoimmunity.
@nl
prefLabel
T cells with low avidity for a ...... erance and cause autoimmunity.
@en
T cells with low avidity for a ...... erance and cause autoimmunity.
@nl
P2860
P1433
P1476
T cells with low avidity for a ...... erance and cause autoimmunity.
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P2093
Dietmar Zehn
Michael J Bevan
P2860
P304
P356
10.1016/J.IMMUNI.2006.06.009
P407
P577
2006-08-03T00:00:00Z