Drug development and the cellular quality control system.
about
Therapeutic rescue of misfolded mutants: validation of primary high throughput screens for identification of pharmacoperone drugsPharmacoperones: a new therapeutic approach for diseases caused by misfolded G protein-coupled receptorsPharmacological chaperoning: a primer on mechanism and pharmacologyMolecular basis of the dominant negative effect of a glycine transporter 2 mutation associated with hyperekplexia.A phenotypic high throughput screening assay for the identification of pharmacoperones for the gonadotropin releasing hormone receptorTrafficking of G-protein-coupled receptors to the plasma membrane: insights for pharmacoperone drugs.Transitioning pharmacoperones to therapeutic use: in vivo proof-of-principle and design of high throughput screens.Salt bridge integrates GPCR activation with protein traffickingChaperoning G protein-coupled receptors: from cell biology to therapeuticsFunctional rescue of Kallmann syndrome-associated prokineticin receptor 2 (PKR2) mutants deficient in traffickingRestoration of testis function in hypogonadotropic hypogonadal mice harboring a misfolded GnRHR mutant by pharmacoperone drug therapy.High-throughput screen for pharmacoperones of the vasopressin type 2 receptorRescue of expression and signaling of human luteinizing hormone G protein-coupled receptor mutants with an allosterically binding small-molecule agonistSalt bridges overlapping the gonadotropin-releasing hormone receptor agonist binding site reveal a coincidence detector for G protein-coupled receptor activation.Pharmacological chaperones for misfolded gonadotropin-releasing hormone receptorsRescue of misrouted GnRHR mutants reveals its constitutive activityDominant protein interactions that influence the pathogenesis of conformational diseases.Pharmacological chaperones as a potential therapeutic option in methylmalonic aciduria cblB type.Species sequence differences determine the interaction of GnRH receptor with the cellular quality control systemMutations in G protein-coupled receptors that impact receptor trafficking and reproductive function.Trafficking and signalling of gonadotrophin-releasing hormone receptors: an automated imaging approach.Pharmacoperone rescue of vasopressin 2 receptor mutants reveals unexpected constitutive activity and coupling bias.Protein misfolding diseases: prospects of pharmacological treatment.Neuroprotective properties of mildronate, a small molecule, in a rat model of Parkinson's disease.
P2860
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P2860
Drug development and the cellular quality control system.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 21 March 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Drug development and the cellular quality control system.
@en
Drug development and the cellular quality control system.
@nl
type
label
Drug development and the cellular quality control system.
@en
Drug development and the cellular quality control system.
@nl
prefLabel
Drug development and the cellular quality control system.
@en
Drug development and the cellular quality control system.
@nl
P1476
Drug development and the cellular quality control system.
@en
P2093
Jo Ann Janovick
P Michael Conn
P304
P356
10.1016/J.TIPS.2009.02.002
P577
2009-03-21T00:00:00Z