A new mouse model for the trisomy of the Abcg1-U2af1 region reveals the complexity of the combinatorial genetic code of down syndrome
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Down syndrome: searching for the genetic culpritsDissecting Alzheimer disease in Down syndrome using mouse modelsMouse models of Down syndrome as a tool to unravel the causes of mental disabilitiesDown Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 HomologuesHippocampal circuit dysfunction in the Tc1 mouse model of Down syndrome.Dosage of the Abcg1-U2af1 region modifies locomotor and cognitive deficits observed in the Tc1 mouse model of Down syndromePharmacological approaches to improving cognitive function in Down syndrome: current status and considerations.The use of mouse models to understand and improve cognitive deficits in Down syndrome.A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions.Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice.Molecular basis of pharmacotherapies for cognition in Down syndromeMechanisms and consequences of aneuploidy and chromosome instability in the aging brainCognition and hippocampal plasticity in the mouse is altered by monosomy of a genomic region implicated in Down syndromeFunctional transcriptome analysis of the postnatal brain of the Ts1Cje mouse model for Down syndrome reveals global disruption of interferon-related molecular networksBrain phenotype of transgenic mice overexpressing cystathionine β-synthase.Abnormal microRNA expression in Ts65Dn hippocampus and whole blood: contributions to Down syndrome phenotypes.Associations between DNA methylation and schizophrenia-related intermediate phenotypes - a gene set enrichment analysisControlled somatic and germline copy number variation in the mouse modelUnravelling genes and pathways implicated in working memory of schizophrenia in Han ChineseOpposite phenotypes of muscle strength and locomotor function in mouse models of partial trisomy and monosomy 21 for the proximal Hspa13-App region.Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling Down syndrome.Mouse models for Down syndrome-associated developmental cognitive disabilitiesThe use of mouse models for understanding the biology of down syndrome and agingGenetic modifiers predisposing to congenital heart disease in the sensitized Down syndrome populationSensitized phenotypic screening identifies gene dosage sensitive region on chromosome 11 that predisposes to disease in miceMolecular and cellular alterations in Down syndrome: toward the identification of targets for therapeuticsGenetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel.The telomeric part of the human chromosome 21 from Cstb to Prmt2 is not necessary for the locomotor and short-term memory deficits observed in the Tc1 mouse model of Down syndromeDown syndrome and the molecular pathogenesis resulting from trisomy of human chromosome 21.Modular transcriptional repertoire and MicroRNA target analyses characterize genomic dysregulation in the thymus of Down syndrome infants.An Integrated Human/Murine Transcriptome and Pathway Approach To Identify Prenatal Treatments For Down Syndrome.Down syndrome: from understanding the neurobiology to therapy.Size does not always matter: Ts65Dn Down syndrome mice show cerebellum-dependent motor learning deficits that cannot be rescued by postnatal SAG treatmentHuman chromosome 21 orthologous region on mouse chromosome 17 is a major determinant of Down syndrome-related developmental cognitive deficitsEfficient and rapid generation of large genomic variants in rats and mice using CRISMEREAnimal models of human genetic diseases: do they need to be faithful to be useful?Is it possible to improve neurodevelopmental abnormalities in Down syndrome?Aging and intellectual disability: insights from mouse models of Down syndrome.Stem and progenitor cell dysfunction in human trisomies.Mouse models of Down syndrome: gene content and consequences.
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A new mouse model for the trisomy of the Abcg1-U2af1 region reveals the complexity of the combinatorial genetic code of down syndrome
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 26 September 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A new mouse model for the tris ...... genetic code of down syndrome
@en
A new mouse model for the tris ...... genetic code of down syndrome.
@nl
type
label
A new mouse model for the tris ...... genetic code of down syndrome
@en
A new mouse model for the tris ...... genetic code of down syndrome.
@nl
prefLabel
A new mouse model for the tris ...... genetic code of down syndrome
@en
A new mouse model for the tris ...... genetic code of down syndrome.
@nl
P2093
P2860
P50
P356
P1476
A new mouse model for the tris ...... genetic code of down syndrome
@en
P2093
Agnès Gruart
Bernadette Chadefaux-Vekemans
Fabrice Trovero
Jean-Charles Bizot
José María Delgado-García
Laetitia Magnol
Paola Prandini
Patricia Lopes Pereira
Samuel Deutsch
Véronique Brault
P2860
P304
P356
10.1093/HMG/DDP438
P577
2009-09-26T00:00:00Z