Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus
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Cellular mechanisms of restored β-cell tolerance mediated by protective alleles of Idd3 and Idd5Use of nonobese diabetic mice to understand human type 1 diabetesDistinct genetic control of autoimmune neuropathy and diabetes in the non-obese diabetic background.IL-21 deficiency influences CD8 T cell quality and recall responses following an acute viral infectionA recombination hotspot leads to sequence variability within a novel gene (AK005651) and contributes to type 1 diabetes susceptibilityInterleukin-21 is critically required in autoimmune and allogeneic responses to islet tissue in murine models.Fine-mapping and transethnic genotyping establish IL2/IL21 genetic association with lupus and localize this genetic effect to IL21Autoreactive cytotoxic T lymphocytes acquire higher expression of cytotoxic effector markers in the islets of NOD mice after priming in pancreatic lymph nodesPremature CD4+ T cell aging and its contribution to lymphopenia-induced proliferation of memory cells in autoimmune-prone non-obese diabetic miceA T cell extrinsic mechanism by which IL-2 dampens Th17 differentiation.Clonal Deletion Prunes but Does Not Eliminate Self-Specific αβ CD8(+) T Lymphocytes.Sleeping Beauty Transposon Mutagenesis as a Tool for Gene Discovery in the NOD Mouse Model of Type 1 DiabetesGenetic interactions among Idd3, Idd5.1, Idd5.2, and Idd5.3 protective loci in the nonobese diabetic mouse model of type 1 diabetes.Innate pro-B-cell progenitors protect against type 1 diabetes by regulating autoimmune effector T cellsInterleukin-21 plays a critical role in the pathogenesis and severity of type I autoimmune hepatitisPathogenic mechanisms in type 1 diabetes: the islet is both target and driver of disease.Comparative genetics: synergizing human and NOD mouse studies for identifying genetic causation of type 1 diabetesReduced IL-2 expression in NOD mice leads to a temporal increase in CD62Llo FoxP3+ CD4+ T cells with limited suppressor activity.β-cell-specific IL-2 therapy increases islet Foxp3+Treg and suppresses type 1 diabetes in NOD mice.Implication of IL-2/IL-21 region in systemic sclerosis genetic susceptibility.IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2.Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease.Targeting interleukin-21 in inflammatory diseases.Interleukin-21 in chronic inflammatory diseases.Advances in our understanding of the pathophysiology of Type 1 diabetes: lessons from the NOD mouse.Expression of IL-2 in β cells by AAV8 gene transfer in pre-diabetic NOD mice prevents diabetes through activation of FoxP3-positive regulatory T cells.CD4 T cell differentiation in type 1 diabetes.Circadian rhythm-related genes: implication in autoimmunity and type 1 diabetes.Congenic mice reveal genetic epistasis and overlapping disease loci for autoimmune diabetes and listeriosis.Altered homeostasis and development of regulatory T cell subsets represent an IL-2R-dependent risk for diabetes in NOD mice.Induction of autoimmune diabetes in non-obese diabetic mice requires interleukin-21-dependent activation of autoreactive CD8⁺ T cells.The Role of NOD Mice in Type 1 Diabetes Research: Lessons from the Past and Recommendations for the Future.The circadian gene Arntl2 on distal mouse chromosome 6 controls thymocyte apoptosis.Thymic B Cell-Mediated Attack of Thymic Stroma Precedes Type 1 Diabetes Development.
P2860
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P2860
Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus
description
article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 30 October 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus
@en
Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus.
@nl
type
label
Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus
@en
Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus.
@nl
prefLabel
Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus
@en
Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus.
@nl
P2860
P50
P356
P1476
Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus
@en
P2093
Helen M McGuire
Natasha Hill
P2860
P304
19438-19443
P356
10.1073/PNAS.0903561106
P407
P577
2009-10-30T00:00:00Z