SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP. - Wikidata - wikimedia - TriplyDB

SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP.

SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP.

http://www.wikidata.org/entity/Q37445045

about

Small-molecule SMAC mimetics as new cancer therapeutics Recognition of Smac-mimetic compounds by the BIR domain of cIAP1 Structural Insight into Inhibitor of Apoptosis Proteins Recognition by a Potent Divalent Smac-Mimetic NF023 binding to XIAP-BIR1: searching drugs for regulation of the NF-κB pathway The paradox role of caspase cascade in ionizing radiation therapy A small molecule SMAC mimic LBW242 potentiates TRAIL- and anticancer drug-mediated cell death of ovarian cancer cells BM-1197: a novel and specific Bcl-2/Bcl-xL inhibitor inducing complete and long-lasting tumor regression in vivo Significant Differences in the Development of Acquired Resistance to the MDM2 Inhibitor SAR405838 between In Vitro and In Vivo Drug Treatment Recent Advances in Biosensing With Photonic Crystal Surfaces: A Review Toll-like receptor-mediated down-regulation of the deubiquitinase cylindromatosis (CYLD) protects macrophages from necroptosis in wild-derived mice Targeting p53 for Novel Anticancer Therapy.Smac mimetic increases chemotherapy response and improves survival in mice with pancreatic cancer Overcoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs)Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and Bortezomib SMAC mimetic BV6 induces cell death in monocytes and maturation of monocyte-derived dendritic cells.Overcoming cancer cell resistance to Smac mimetic induced apoptosis by modulating cIAP-2 expression Parallel synthesis and biological evaluation of 837 analogues of procaspase-activating compound 1 (PAC-1)Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins.Smac mimetic SM-164 potentiates APO2L/TRAIL- and doxorubicin-mediated anticancer activity in human hepatocellular carcinoma cells The API2-MALT1 fusion exploits TNFR pathway-associated RIP1 ubiquitination to promote oncogenic NF-κB signaling.Therapeutic potential and molecular mechanism of a novel, potent, nonpeptide, Smac mimetic SM-164 in combination with TRAIL for cancer treatment Smac mimetics increase cancer cell response to chemotherapeutics in a TNF-α-dependent manner Potent bivalent Smac mimetics: effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity.Potent and selective small-molecule inhibitors of cIAP1/2 proteins reveal that the binding of Smac mimetics to XIAP BIR3 is not required for their effective induction of cell death in tumor cells.Genome-wide immunity studies in the rabbit: transcriptome variations in peripheral blood mononuclear cells after in vitro stimulation by LPS or PMA-Ionomycin Detection of protein-small molecule binding using a self-referencing external cavity laser biosensor.Discovery of novel second mitochondria-derived activator of caspase mimetics as selective inhibitor of apoptosis protein inhibitors.Removal of Metabolic Liabilities Enables Development of Derivatives of Procaspase-Activating Compound 1 (PAC-1) with Improved Pharmacokinetics Lipid-conjugated Smac analogues.LRIG1 modulates cancer cell sensitivity to Smac mimetics by regulating TNFα expression and receptor tyrosine kinase signaling Inhibitor of apoptosis proteins as intracellular signaling intermediates.Derivatives of Procaspase-Activating Compound 1 (PAC-1) and their Anticancer Activities.A novel role for RIP1 kinase in mediating TNFα production.Hyaluronan-CD44v3 interaction with Oct4-Sox2-Nanog promotes miR-302 expression leading to self-renewal, clonal formation, and cisplatin resistance in cancer stem cells from head and neck squamous cell carcinoma cIAP1 and cIAP2 limit macrophage necroptosis by inhibiting Rip1 and Rip3 activation.A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed.A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment.Targeting inhibitors of apoptosis proteins (IAPs) for new breast cancer therapeutics AT-406, an orally active antagonist of multiple inhibitor of apoptosis proteins, inhibits progression of human ovarian cancer.X-linked inhibitor of apoptosis regulates lung fibroblast resistance to Fas-mediated apoptosis.

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P2860

SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP.

http://www.wikidata.org/entity/Q37445045

description

2008 nî lūn-bûn

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2008年の論文

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年學術文章

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2008年學術文章

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2008年學術文章

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name

SM-164: a novel, bivalent Smac ...... blockade of cIAP-1/2 and XIAP.

@en

SM-164: a novel, bivalent Smac ...... blockade of cIAP-1/2 and XIAP.

@nl

type

label

SM-164: a novel, bivalent Smac ...... blockade of cIAP-1/2 and XIAP.

@en

SM-164: a novel, bivalent Smac ...... blockade of cIAP-1/2 and XIAP.

@nl

prefLabel

SM-164: a novel, bivalent Smac ...... blockade of cIAP-1/2 and XIAP.

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SM-164: a novel, bivalent Smac ...... blockade of cIAP-1/2 and XIAP.

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0008-5472.CAN-08-2655

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Cancer Research

P1476

SM-164: a novel, bivalent Smac ...... blockade of cIAP-1/2 and XIAP.

@en

P2093

Donna McEachern

http://www.w3.org/2001/XMLSchema#string

Haiying Sun

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Han Yi

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Jeanne A Stuckey

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Jennifer L Meagher

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Jianfeng Lu

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Longchuan Bai

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Rebecca S Miller

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Sanjeev Shangary

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Shaomeng Wang

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P2860

Structural basis of caspase-7 inhibition by XIAP

Structural basis for the inhibition of caspase-3 by XIAP

Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases

IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

TNF-alpha induces two distinct caspase-8 activation pathways

Upstream regulatory role for XIAP in receptor-mediated apoptosis

Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis

NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP

Structural and biochemical basis of apoptotic activation by Smac/DIABLO

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9384-9393

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10.1158/0008-5472.CAN-08-2655

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22

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68

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2008-11-01T00:00:00Z

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23475246

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19010913

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apoptotic process

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2784911

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