PD-118057 contacts the pore helix of hERG1 channels to attenuate inactivation and enhance K+ conductance.
about
A molecular switch driving inactivation in the cardiac K+ channel HERGPharmacologic Approach to Defective Protein Trafficking in the E637K-hERG Mutant with PD-118057 and ThapsigarginAntiarrhythmics cure brain arrhythmia: The imperativeness of subthalamic ERG K+ channels in parkinsonian discharges.In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome.Activation of human ether-a-go-go related gene (hERG) potassium channels by small moleculesDifferential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channelsIdentification of human Ether-à-go-go related gene modulators by three screening platforms in an academic drug-discovery setting.Molecular determinants of human ether-à-go-go-related gene 1 (hERG1) K+ channel activation by NS1643Concatenated hERG1 tetramers reveal stoichiometry of altered channel gating by RPR-260243Molecular determinants for activation of human ether-à-go-go-related gene 1 potassium channels by 3-nitro-n-(4-phenoxyphenyl) benzamide.Pore helices play a dynamic role as integrators of domain motion during Kv11.1 channel inactivation gating.New potential binding determinant for hERG channel inhibitors.In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome.The gating charge pathway of an epilepsy-associated potassium channel accommodates chemical ligands.A new hERG allosteric modulator rescues genetic and drug-induced long-QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells.Stoichiometry of altered hERG1 channel gating by small molecule activatorsHERG1 channel agonists and cardiac arrhythmia.Revealing the structural basis of action of hERG potassium channel activators and blockers.Molecular basis of potassium channels in pancreatic duct epithelial cellsMolecular Basis of Cardiac Delayed Rectifier Potassium Channel Function and Pharmacology.Pharmacological and electrophysiological characterization of AZSMO-23, an activator of the hERG K(+) channel.Molecular Pathophysiology of Congenital Long QT Syndrome.An allosteric mechanism for drug block of the human cardiac potassium channel KCNQ1.Ginsenoside Rg3, a Gating Modifier of EAG Family K+ Channels.Molecular Basis of Altered hERG1 Channel Gating Induced by Ginsenoside Rg3.
P2860
Q28481507-D9A95E46-D183-4FDA-AB85-C4C937170A9AQ28533988-427928DC-7BAF-4979-A83C-B34E9234EE9EQ29994716-7C309602-4C6B-45AA-AACB-C5E66EB2AF40Q33791988-D2AE4026-60B4-40A1-9861-9A0919453A14Q33859184-555B53FF-9D02-420F-AA61-B588389A6964Q34342271-DD10BF0D-2149-4E7A-B522-2CBED7DF67E4Q34407398-4CC53039-AAD8-49A1-A955-9A31F0BA2EA6Q34458432-98970551-CE98-4D07-9EC6-A10671E9CC1FQ35156395-C047F52C-C926-4093-9A48-9A87F347CF88Q35275326-08CCAAC2-5EE3-4303-9D00-AC79DB7A6FE6Q36779531-90FD05AC-6375-4AAE-B85E-A50479C00B24Q36789993-92CCFC1C-58EB-4DC8-806E-9AABAA561C8AQ37072877-07D39E93-F9F0-40BB-9B2D-23428F59EC54Q37172414-18CBBE41-ECA1-482B-A3A4-A8721837FE11Q37228986-ED58C394-A011-459C-BB7B-A354E5513E45Q37677449-835C0D14-B49E-4527-B065-5EA988D32BA8Q37699209-074D1D0D-1FE7-4203-B82F-3B44E3D2ADF2Q37774138-5628E033-1F6B-428D-831A-12686096C9CFQ38130386-E1CA9030-296F-44A5-9176-1CC86BB75CC6Q38854244-D2F6B995-4EF9-4E24-AE25-35C64B81E1B2Q38909233-91B98A9C-0D68-4B6A-90F1-2348953F51FAQ38997049-4D9C1C3F-F967-47BA-966C-CB43BCD0D93FQ39236123-6FEC5107-C713-458C-8209-4416126F6B69Q41653882-F6D4D9D9-6DB7-43DD-9837-74478A4507B1Q48517340-9962058E-1A7F-40A4-9F40-9432FDE0F46A
P2860
PD-118057 contacts the pore helix of hERG1 channels to attenuate inactivation and enhance K+ conductance.
description
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name
PD-118057 contacts the pore he ...... on and enhance K+ conductance.
@en
PD-118057 contacts the pore he ...... on and enhance K+ conductance.
@nl
type
label
PD-118057 contacts the pore he ...... on and enhance K+ conductance.
@en
PD-118057 contacts the pore he ...... on and enhance K+ conductance.
@nl
prefLabel
PD-118057 contacts the pore he ...... on and enhance K+ conductance.
@en
PD-118057 contacts the pore he ...... on and enhance K+ conductance.
@nl
P2093
P2860
P356
P1476
PD-118057 contacts the pore he ...... on and enhance K+ conductance.
@en
P2093
Frank B Sachse
Jennifer Abbruzzese
Matthew Perry
Michael C Sanguinetti
P2860
P304
20075-20080
P356
10.1073/PNAS.0906597106
P407
P577
2009-11-05T00:00:00Z