Detailed mechanistic insights into HIV-1 sensitivity to three generations of fusion inhibitors.
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Broad Antiviral Activity and Crystal Structure of HIV-1 Fusion Inhibitor SifuvirtideA next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodiesSusceptibility of HIV-1 subtypes B', CRF07_BC and CRF01_AE that are predominantly circulating in China to HIV-1 entry inhibitorsAn inducible cell-cell fusion system with integrated ability to measure the efficiency and specificity of HIV-1 entry inhibitorsTwo M-T hook residues greatly improve the antiviral activity and resistance profile of the HIV-1 fusion inhibitor SC29EK.Origins of resistance to the HIVgp41 viral entry inhibitor T20.Novel recombinant engineered gp41 N-terminal heptad repeat trimers and their potential as anti-HIV-1 therapeutics or microbicidesCross-resistance mechanism of respiratory syncytial virus against structurally diverse entry inhibitors.Biophysical property and broad anti-HIV activity of albuvirtide, a 3-maleimimidopropionic acid-modified peptide fusion inhibitor.Resistance to N-peptide fusion inhibitors correlates with thermodynamic stability of the gp41 six-helix bundle but not HIV entry kinetics.Resistance profiles of novel electrostatically constrained HIV-1 fusion inhibitors.In vitro selection and characterization of HIV-1 variants with increased resistance to sifuvirtide, a novel HIV-1 fusion inhibitor.Increasing hydrophobicity of residues in an anti-HIV-1 Env peptide synergistically improves potencyBiochemistry and biophysics of HIV-1 gp41 - membrane interactions and implications for HIV-1 envelope protein mediated viral-cell fusion and fusion inhibitor designMechanism of HIV-1 Resistance to Short-Peptide Fusion Inhibitors Targeting the Gp41 PocketTargeting HIV-1 envelope glycoprotein trimers to B cells by using APRIL improves antibody responses.Genetic Pathway of HIV-1 Resistance to Novel Fusion Inhibitors Targeting the Gp41 Pocket.A cholesterol tag at the N terminus of the relatively broad-spectrum fusion inhibitory peptide targets an earlier stage of fusion glycoprotein activation and increases the peptide's antiviral potency in vivo.Molecular determinants defining the triggering range of prefusion F complexes of canine distemper virusInsights into the mechanism of HIV-1 envelope induced membrane fusion as revealed by its inhibitory peptides.Amphipathic properties of HIV-1 gp41 fusion inhibitors.Escape from human immunodeficiency virus type 1 (HIV-1) entry inhibitors.Potential mechanisms for cell-based gene therapy to treat HIV/AIDS.Resistance of human immunodeficiency virus type 1 to a third-generation fusion inhibitor requires multiple mutations in gp41 and is accompanied by a dramatic loss of gp41 functionThe impact of HIV-1 genetic diversity on the efficacy of a combinatorial RNAi-based gene therapy.HIV-1 Escape from a Peptidic Anchor Inhibitor through Stabilization of the Envelope Glycoprotein SpikeThe heptad repeat region is a major selection target in MERS-CoV and related coronaviruses.The M-T hook structure increases the potency of HIV-1 fusion inhibitor sifuvirtide and overcomes drug resistance.Further Characterization of the Bifunctional HIV Entry Inhibitor sCD4-FIT45.Mechanism of HIV-1 Resistance to an Electronically Constrained α-Helical Peptide Membrane Fusion Inhibitor.New pathogenic viruses and novel antiviral drugs.Structural Insights into the Mechanisms of Action of Short-Peptide HIV-1 Fusion Inhibitors Targeting the Gp41 Pocket.A Universal Approach to Optimize the Folding and Stability of Prefusion-Closed HIV-1 Envelope Trimers.HIV Entry and Its Inhibition by Bifunctional Antiviral Proteins
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P2860
Detailed mechanistic insights into HIV-1 sensitivity to three generations of fusion inhibitors.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 17 July 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Detailed mechanistic insights ...... erations of fusion inhibitors.
@en
Detailed mechanistic insights ...... erations of fusion inhibitors.
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type
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Detailed mechanistic insights ...... erations of fusion inhibitors.
@en
Detailed mechanistic insights ...... erations of fusion inhibitors.
@nl
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Detailed mechanistic insights ...... erations of fusion inhibitors.
@en
Detailed mechanistic insights ...... erations of fusion inhibitors.
@nl
P2093
P2860
P356
P1476
Detailed mechanistic insights ...... erations of fusion inhibitors.
@en
P2093
Alexandre M J J Bonvin
Ben Berkhout
Dirk Eggink
Johannes P M Langedijk
Rogier W Sanders
P2860
P304
26941-26950
P356
10.1074/JBC.M109.004416
P407
P50
P577
2009-07-17T00:00:00Z