Ligand binding and micro-switches in 7TM receptor structures.
about
Ligand modulation of the Epstein-Barr virus-induced seven-transmembrane receptor EBI2: identification of a potent and efficacious inverse agonistβ-Arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKRThe impact of GPCR structures on pharmacology and structure-based drug designStructural Studies of G Protein-Coupled ReceptorsBiased and g protein-independent signaling of chemokine receptorsDiversity and modularity of G protein-coupled receptor structuresConstitutively active rhodopsin and retinal diseaseMolecular Evolution and Functional Divergence of Trace Amine-Associated ReceptorsCommunication over the network of binary switches regulates the activation of A2A adenosine receptorLigand-specific regulation of the extracellular surface of a G-protein-coupled receptorStructural Basis for Allosteric Regulation of GPCRs by Sodium IonsConopeptide -TIA Defines a New Allosteric Site on the Extracellular Surface of the 1B-AdrenoceptorStructural Features for Functional Selectivity at Serotonin ReceptorsCutting edge: GPR35/CXCR8 is the receptor of the mucosal chemokine CXCL17Biased signaling of the angiotensin II type 1 receptor can be mediated through distinct mechanismsA dynamic view of molecular switch behavior at serotonin receptors: implications for functional selectivityThe Quantum Nature of Drug-Receptor Interactions: Deuteration Changes Binding Affinities for Histamine Receptor LigandsRetinal conformation governs pKa of protonated Schiff base in rhodopsin activationStructure and dynamics of DRD4 bound to an agonist and an antagonist using in silico approaches.Differential light-induced responses in sectorial inherited retinal degeneration.A network of molecular switches controls the activation of the two-component response regulator NtrC.Structure and function of serotonin G protein-coupled receptors.G-protein-coupled receptor structure, ligand binding and activation as studied by solid-state NMR spectroscopy.Feeding-dependent activation of enteric cells and sensory neurons by lymphatic fluid: evidence for a neurolymphocrine system.Structure-function of the G protein-coupled receptor superfamily.Structure-based simulations reveal concerted dynamics of GPCR activationRetinal ligand mobility explains internal hydration and reconciles active rhodopsin structuresLigand-based peptide design and combinatorial peptide libraries to target G protein-coupled receptorsLigand-induced rearrangements of the GABA(B) receptor revealed by fluorescence resonance energy transfer.CoMFA analyses of C-2 position salvinorin A analogs at the kappa-opioid receptor provides insights into epimer selectivity.An angiotensin II type 1 receptor activation switch patch revealed through evolutionary trace analysis.Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery.Allosteric sodium in class A GPCR signalingStructure and function of G protein-coupled receptors using NMR spectroscopy.Mapping substance P binding sites on the neurokinin-1 receptor using genetic incorporation of a photoreactive amino acid.Tachykinin neurokinin 3 receptor antagonists: a patent review (2005 - 2010).Third extracellular loop (EC3)-N terminus interaction is important for seven-transmembrane domain receptor function: implications for an activation microswitch region.Action of molecular switches in GPCRs--theoretical and experimental studies.An unbalanced translocation unmasks a recessive mutation in the follicle-stimulating hormone receptor (FSHR) gene and causes FSH resistance.The antiquity of chordate odorant receptors is revealed by the discovery of orthologs in the cnidarian Nematostella vectensis.
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Ligand binding and micro-switches in 7TM receptor structures.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 16 April 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Ligand binding and micro-switches in 7TM receptor structures.
@en
Ligand binding and micro-switches in 7TM receptor structures.
@nl
type
label
Ligand binding and micro-switches in 7TM receptor structures.
@en
Ligand binding and micro-switches in 7TM receptor structures.
@nl
prefLabel
Ligand binding and micro-switches in 7TM receptor structures.
@en
Ligand binding and micro-switches in 7TM receptor structures.
@nl
P50
P1476
Ligand binding and micro-switches in 7TM receptor structures.
@en
P2093
Rie Nygaard
Thomas M Frimurer
P304
P356
10.1016/J.TIPS.2009.02.006
P577
2009-04-16T00:00:00Z