SMN is essential for the biogenesis of U7 small nuclear ribonucleoprotein and 3'-end formation of histone mRNAs. - Wikidata - wikimedia - TriplyDB

SMN is essential for the biogenesis of U7 small nuclear ribonucleoprotein and 3'-end formation of histone mRNAs.

SMN is essential for the biogenesis of U7 small nuclear ribonucleoprotein and 3'-end formation of histone mRNAs.

http://www.wikidata.org/entity/Q37451229

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A large animal model of spinal muscular atrophy and correction of phenotype.Pharmacokinetics, pharmacodynamics, and efficacy of a small-molecule SMN2 splicing modifier in mouse models of spinal muscular atrophy Spinal muscular atrophy: journeying from bench to bedside Disease mechanisms and therapeutic approaches in spinal muscular atrophy.Transcriptomic Changes Due to Cytoplasmic TDP-43 Expression Reveal Dysregulation of Histone Transcripts and Nuclear Chromatin.Low levels of Survival Motor Neuron protein are sufficient for normal muscle function in the SMNΔ7 mouse model of SMA.Cajal bodies are linked to genome conformation Deficiency of the Survival of Motor Neuron Protein Impairs mRNA Localization and Local Translation in the Growth Cone of Motor Neurons.A U1 snRNP-specific assembly pathway reveals the SMN complex as a versatile hub for RNP exchange RNA-sequencing of a mouse-model of spinal muscular atrophy reveals tissue-wide changes in splicing of U12-dependent introns.Plastin-3 extends survival and reduces severity in mouse models of spinal muscular atrophy.SMN control of RNP assembly: from post-transcriptional gene regulation to motor neuron disease.Developing therapies for spinal muscular atrophy.RNA processing-associated molecular mechanisms of neurodegenerative diseases.Linking amyotrophic lateral sclerosis and spinal muscular atrophy through RNA-transcriptome homeostasis: a genomics perspective.Diverse role of survival motor neuron protein.Downregulation of Survivin contributes to cell-cycle arrest during postnatal cardiac development in a severe spinal muscular atrophy mouse model.In Vivo Translatome Profiling in Spinal Muscular Atrophy Reveals a Role for SMN Protein in Ribosome Biology.CBP-mediated SMN acetylation modulates Cajal body biogenesis and the cytoplasmic targeting of SMN.Neurochondrin interacts with the SMN protein suggesting a novel mechanism for Spinal Muscular Atrophy pathology.Searching the overlap between network modules with specific betweeness (S2B) and its application to cross-disease analysis

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SMN is essential for the biogenesis of U7 small nuclear ribonucleoprotein and 3'-end formation of histone mRNAs.

http://www.wikidata.org/entity/Q37451229

description

article científic

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article scientifique

@fr

articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on December 2013

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

SMN is essential for the bioge ...... nd formation of histone mRNAs.

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SMN is essential for the bioge ...... nd formation of histone mRNAs.

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type

label

SMN is essential for the bioge ...... nd formation of histone mRNAs.

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SMN is essential for the bioge ...... nd formation of histone mRNAs.

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prefLabel

SMN is essential for the bioge ...... nd formation of histone mRNAs.

@en

SMN is essential for the bioge ...... nd formation of histone mRNAs.

@nl

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J.CELREP.2013.11.012

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SMN is essential for the bioge ...... end formation of histone mRNAs

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Charlotte J Sumner

http://www.w3.org/2001/XMLSchema#string

Francesco Lotti

http://www.w3.org/2001/XMLSchema#string

George Z Mentis

http://www.w3.org/2001/XMLSchema#string

James P Van Meerbeke

http://www.w3.org/2001/XMLSchema#string

Luciano Saieva

http://www.w3.org/2001/XMLSchema#string

Sarah Tisdale

http://www.w3.org/2001/XMLSchema#string

Thomas O Crawford

http://www.w3.org/2001/XMLSchema#string

P2860

Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein

ZFP100, a component of the active U7 snRNP limiting for histone pre-mRNA processing, is required for entry into S phase

Knockdown of SLBP results in nuclear retention of histone mRNA

Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing

Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesis

The special Sm core structure of the U7 snRNP: far-reaching significance of a small nuclear ribonucleoprotein

Metabolism and regulation of canonical histone mRNAs: life without a poly(A) tail

A role for SMN exon 7 splicing in the selective vulnerability of motor neurons in spinal muscular atrophy

Formation of the 3' end of histone mRNA: getting closer to the end

GammaH2AX and cancer

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1187-1195

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scholarly article

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10.1016/J.CELREP.2013.11.012

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5

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5

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Livio Pellizzoni

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2013-12-01T00:00:00Z

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259317435

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24332368

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ribonucleoprotein

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3885245

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