Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesis
about
Structure of a key intermediate of the SMN complex reveals Gemin2's crucial function in snRNP assemblyGemin5 Binds to the Survival Motor Neuron mRNA to Regulate SMN ExpressionStructural insights into Gemin5-guided selection of pre-snRNAs for snRNP assemblyThe RNA-binding protein Gemin5 binds directly to the ribosome and regulates global translationThe SMN structure reveals its crucial role in snRNP assemblySMN in spinal muscular atrophy and snRNP biogenesisSpinal Muscular Atrophy: From Defective Chaperoning of snRNP Assembly to Neuromuscular Dysfunction.tRNA and cytochrome c in cell death and beyond.GEMINs: potential therapeutic targets for spinal muscular atrophy?Proteomic and 3D structure analyses highlight the C/D box snoRNP assembly mechanism and its control.The Gemin associates of survival motor neuron are required for motor function in Drosophila.Human regulator of telomere elongation helicase 1 (RTEL1) is required for the nuclear and cytoplasmic trafficking of pre-U2 RNA.U1 snRNP is mislocalized in ALS patient fibroblasts bearing NLS mutations in FUS and is required for motor neuron outgrowth in zebrafishGenetic Interactions between the Members of the SMN-Gemins Complex in Drosophila.Reconstitution of the human U snRNP assembly machinery reveals stepwise Sm protein organizationNUFIP and the HSP90/R2TP chaperone bind the SMN complex and facilitate assembly of U4-specific proteins.Implication of the SMN complex in the biogenesis and steady state level of the signal recognition particle.A U1 snRNP-specific assembly pathway reveals the SMN complex as a versatile hub for RNP exchangeSMN is essential for the biogenesis of U7 small nuclear ribonucleoprotein and 3'-end formation of histone mRNAs.Structural basis for specific recognition of pre-snRNA by Gemin5.Fam118B, a newly identified component of Cajal bodies, is required for Cajal body formation, snRNP biogenesis and cell viability.Biogenesis of spliceosomal small nuclear ribonucleoproteins.Spliceosomal small nuclear ribonucleoprotein biogenesis defects and motor neuron selectivity in spinal muscular atrophy.A day in the life of the spliceosomeGem depletion: amyotrophic lateral sclerosis and spinal muscular atrophy crossover.SMN control of RNP assembly: from post-transcriptional gene regulation to motor neuron disease.Gemin5: A Multitasking RNA-Binding Protein Involved in Translation Control.p54nrb/NonO and PSF promote U snRNA nuclear export by accelerating its export complex assembly.UsnRNP biogenesis: mechanisms and regulation.Analysis of the human immunodeficiency virus-1 RNA packageome.SMN - A chaperone for nuclear RNP social occasions?Linking amyotrophic lateral sclerosis and spinal muscular atrophy through RNA-transcriptome homeostasis: a genomics perspective.Gemin5 proteolysis reveals a novel motif to identify L protease targets.Identification of novel non-canonical RNA-binding sites in Gemin5 involved in internal initiation of translation.Human ribosomal protein eS1 is engaged in cellular events related to processing and functioning of U11 snRNA.Telomerase RNA biogenesis involves sequential binding by Sm and Lsm complexes.Identification of truncated forms of U1 snRNA reveals a novel RNA degradation pathway during snRNP biogenesis.Gemin5 promotes IRES interaction and translation control through its C-terminal region.Minor introns are embedded molecular switches regulated by highly unstable U6atac snRNA.Impaired spliceosomal UsnRNP assembly leads to Sm mRNA down-regulation and Sm protein degradation.
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Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesis
description
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2010
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im Mai 2010 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2010/05/28)
@sk
vědecký článek publikovaný v roce 2010
@cs
wetenschappelijk artikel (gepubliceerd op 2010/05/28)
@nl
наукова стаття, опублікована в травні 2010
@uk
مقالة علمية (نشرت في 28-5-2010)
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name
Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesis
@ast
Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesis
@en
Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesis
@nl
type
label
Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesis
@ast
Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesis
@en
Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesis
@nl
prefLabel
Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesis
@ast
Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesis
@en
Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesis
@nl
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P921
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P1476
Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesis
@en
P2093
Gideon Dreyfuss
Jennifer L. Bachorik
Jeongsik Yong
Mumtaz Kasim
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P304
P3181
P356
10.1016/J.MOLCEL.2010.03.014
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2010-05-28T00:00:00Z