Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation.
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Harnessing Mechanistic Knowledge on Beneficial Versus Deleterious IFN-I Effects to Design Innovative Immunotherapies Targeting Cytokine Activity to Specific Cell TypesHeat shock protein-90-alpha, a prolactin-STAT5 target gene identified in breast cancer cells, is involved in apoptosis regulationThe intracellular domain of ErbB4 induces differentiation of mammary epithelial cellsThe tumor suppressor hTid1 inhibits STAT5b activity via functional interactionMammary gland developmentIL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cellsNuclear Jak2 and transcription factor NF1-C2: a novel mechanism of prolactin signaling in mammary epithelial cellsSuppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivoMacrophages: Regulators of the Inflammatory Microenvironment during Mammary Gland Development and Breast CancerPharmacological overview of galactogoguesDiversification of dendritic cell subsets: Emerging roles for STAT proteinsSTAT5-regulated microRNA-193b controls haematopoietic stem and progenitor cell expansion by modulating cytokine receptor signalling.Miz1 deficiency in the mammary gland causes a lactation defect by attenuated Stat5 expression and phosphorylationD-type Cyclins are important downstream effectors of cytokine signaling that regulate the proliferation of normal and neoplastic mammary epithelial cells.What Is Breast in the Bone?PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesisLactation defect in a widely used MMTV-Cre transgenic line of miceThe JAK-STAT transcriptional regulator, STAT-5, activates the ATM DNA damage pathway to induce HPV 31 genome amplification upon epithelial differentiationA brain-specific homeobox gene, Bsx, is essential for proper postnatal growth and nursingThe Stat6-regulated KRAB domain zinc finger protein Zfp157 regulates the balance of lineages in mammary glands and compensates for loss of Gata-3Development of mammary luminal progenitor cells is controlled by the transcription factor STAT5AJanus kinase 2 is required for the initiation but not maintenance of prolactin-induced mammary cancerThe transcription factors STAT5A/B regulate GM-CSF-mediated granulopoiesis.Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5.Favorable prognostic value of SOCS2 and IGF-I in breast cancer.Loss of cytokine-STAT5 signaling in the CNS and pituitary gland alters energy balance and leads to obesityDistinct gene-expression profiles characterize mammary tumors developed in transgenic mice expressing constitutively active and C-terminally truncated variants of STAT5.Gab2 promotes hematopoietic stem cell maintenance and self-renewal synergistically with STAT5Growth hormone and insulin-like growth factor-I in the transition from normal mammary development to preneoplastic mammary lesions.A dual role for oncostatin M signaling in the differentiation and death of mammary epithelial cells in vivo.Prolactin-induced neuroprotection against glutamate excitotoxicity is mediated by the reduction of [Ca2+]i overload and NF-κB activation.STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative diseaseMechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia.Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) and IPEX-related disorders: an evolving web of heritable autoimmune diseases.Trp63 is regulated by STAT5 in mammary tissue and subject to differentiation in cancer.VHL deletion impairs mammary alveologenesis but is not sufficient for mammary tumorigenesis.Distinct roles of the three Akt isoforms in lactogenic differentiation and involution.Signal transducer and activator of transcription 5a mediates mammary ductal branching and proliferation in the nulliparous mouse.Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation.Stat5 promotes survival of mammary epithelial cells through transcriptional activation of a distinct promoter in Akt1.
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P2860
Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on September 2004
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Inactivation of Stat5 in mouse ...... survival, and differentiation.
@en
Inactivation of Stat5 in mouse ...... survival, and differentiation.
@nl
type
label
Inactivation of Stat5 in mouse ...... survival, and differentiation.
@en
Inactivation of Stat5 in mouse ...... survival, and differentiation.
@nl
prefLabel
Inactivation of Stat5 in mouse ...... survival, and differentiation.
@en
Inactivation of Stat5 in mouse ...... survival, and differentiation.
@nl
P2093
P2860
P1476
Inactivation of Stat5 in mouse ...... survival, and differentiation.
@en
P2093
Chu-Xia Deng
Cuiling Li
Gertraud W Robinson
Greg Riedlinger
Keiko Miyoshi
Yongzhi Cui
P2860
P304
P356
10.1128/MCB.24.18.8037-8047.2004
P407
P577
2004-09-01T00:00:00Z