Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia. - Wikidata - wikimedia - TriplyDB

Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia.

Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia.

http://www.wikidata.org/entity/Q37524180

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Activation of protein phosphatase 2A tumor suppressor as potential treatment of pancreatic cancer.Modeling of Chronic Myeloid Leukemia: An Overview of In Vivo Murine and Human Xenograft Models Zebrafish Models of Human Leukemia: Technological Advances and Mechanistic Insights Zebrafish as a model for leukemia and other hematopoietic disorders The Basic Biology of PP2A in Hematologic Cells and Malignancies Dopamine receptors - IUPHAR Review 13 Oceans of opportunity: exploring vertebrate hematopoiesis in zebrafish Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth.Zebrafish as a model to assess cancer heterogeneity, progression and relapse.Therapeutic strategies to inhibit MYC 15 years of zebrafish chemical screening Attacking the supply wagons to starve cancer cells to death.Loss of function tp53 mutations do not accelerate the onset of myc-induced T-cell acute lymphoblastic leukaemia in the zebrafish Therapeutic Re-Activation of Protein Phosphatase 2A in Acute Myeloid Leukemia Short-hairpin RNA library: identification of therapeutic partners for gefitinib-resistant non-small cell lung cancer.Danio rerio: Small Fish Making a Big Splash in Leukemia High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells.B56δ-related protein phosphatase 2A dysfunction identified in patients with intellectual disability.Chemical screening in zebrafish for novel biological and therapeutic discovery.Preclinical Models Provide Scientific Justification and Translational Relevance for Moving Novel Therapeutics into Clinical Trials for Pediatric Cancer.A small molecule screen identifies in vivo modulators of peripheral nerve regeneration in zebrafish.The Zebrafish as a Tool to Cancer Drug Discovery.Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer Single-cell transcriptional analysis of normal, aberrant, and malignant hematopoiesis in zebrafish Pharmacological exploitation of the phenothiazine antipsychotics to develop novel antitumor agents-A drug repurposing strategy.PLA2G16 promotes osteosarcoma metastasis and drug resistance via the MAPK pathway.Zebrafish Models of Prader-Willi Syndrome: Fast Track to Pharmacotherapeutics.Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia.New Approaches to Target T-ALL.The Interplay between PP2A and microRNAs in Leukemia.Zebrafish as tools for drug discovery.All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase.A SMAP in the face for cancer.Ligands for Ser/Thr phosphoprotein phosphatases: a patent review (2005-2015).Anti-tumor effects of perphenazine on canine lymphoma.LITTLE FISH, BIG DATA: ZEBRAFISH AS A MODEL FOR CARDIOVASCULAR AND METABOLIC DISEASE.Oncogenic Notch signaling in T-cell and B-cell lymphoproliferative disorders.Identifying Novel Cancer Therapies Using Chemical Genetics and Zebrafish.Effects of TNF-α on Cementoblast Differentiation, Mineralization, and Apoptosis.The Varied Roles of Notch in Cancer.

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Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia.

http://www.wikidata.org/entity/Q37524180

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

@pt

bilimsel makale

@tr

scientific article published on 09 January 2014

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia.

@en

Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia.

@nl

type

label

Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia.

@en

Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia.

@nl

prefLabel

Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia.

@en

Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia.

@nl

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Journal of Clinical Investigation

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Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia

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A Thomas Look

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Andrew P Weng

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Casie Reed

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Constantine Mitsiades

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Elena Kozakewich

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Frank An

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Frederic Baleydier

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Hanno Steen

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Huipin Yuan

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James E Bradner

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P2860

The tumor suppressor PP2A Abeta regulates the RalA GTPase

Identification of PP2A complexes and pathways involved in cell transformation

Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis

CIP2A inhibits PP2A in human malignancies

Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia

Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation.

Whole transcriptome sequencing reveals recurrent NOTCH1 mutations in mantle cell lymphoma.

nacre encodes a zebrafish microphthalmia-related protein that regulates neural-crest-derived pigment cell fate

Serine/threonine phosphatases: mechanism through structure

Protein phosphatase 2A forms a molecular complex with Shc and regulates Shc tyrosine phosphorylation and downstream mitogenic signaling

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644-655

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scholarly article

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10.1172/JCI65093

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2

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124

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Alejandro Gutierrez

Francoise Pflumio

Richard W Groen

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2014-01-09T00:00:00Z

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24401270

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apoptotic process

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3904599

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