about
Speed of leukemia development and genetic diversity in xenograft models of T cell acute lymphoblastic leukemia.Clinical relevance of tumor cells with stem-like properties in pediatric brain tumors.PUMILIO/FOXP1 signaling drives expansion of hematopoietic stem/progenitor and leukemia cells.Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss.Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKLInterleukin-18 produced by bone marrow-derived stromal cells supports T-cell acute leukaemia progressionAssessment of human multi-potent hematopoietic stem/progenitor cell potential using a single in vitro screening system.Comparison Between Several Integrase-defective Lentiviral Vectors Reveals Increased Integration of an HIV Vector Bearing a D167H Mutant.Clonal selection in xenografted human T cell acute lymphoblastic leukemia recapitulates gain of malignancy at relapseHigh-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling.Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia.UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemiaDNMT3A(R882H) mutant and Tet2 inactivation cooperate in the deregulation of DNA methylation control to induce lymphoid malignancies in miceHuman CD34+ cells differentiate into microglia and express recombinant therapeutic proteinPhenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia.Stem Cell Leukemia: how a TALented actor can go awry on the hematopoietic stage.A systems biology approach for defining the molecular framework of the hematopoietic stem cell niche.Triggering the TCR Developmental Checkpoint Activates a Therapeutically Targetable Tumor Suppressive Pathway in T-cell Leukemia.The HOXB4 homeoprotein differentially promotes ex vivo expansion of early human lymphoid progenitors.CD4 regulation in human lymphoid non-T-cells: a role for the silencer element.HOXC4 homeoprotein efficiently expands human hematopoietic stem cells and triggers similar molecular alterations as HOXB4Modeling human hematopoiesis in immunodeficient mice.Lentivirus-mediated gene transfer in primary T cells is enhanced by a central DNA flap.Characterization of DNA-binding-dependent and -independent functions of SCL/TAL1 during human erythropoiesis.Alternative lengthening of telomeres in human glioma stem cells.Lymphoid-affiliated genes are associated with active histone modifications in human hematopoietic stem cells.SCL/TAL1 expression level regulates human hematopoietic stem cell self-renewal and engraftment.Single-cell analysis reveals the continuum of human lympho-myeloid progenitor cells.Bone marrow hematons: An access point to the human hematopoietic niche.Rapid childhood T-ALL growth in xenograft models correlates with mature phenotype and NF-κB pathway activation but not with poor prognosis.SPRED1, a RAS MAPK pathway inhibitor that causes Legius syndrome, is a tumour suppressor downregulated in paediatric acute myeloblastic leukaemia.Transduced CD34+ cells from adrenoleukodystrophy patients with HIV-derived vector mediate long-term engraftment of NOD/SCID mice.Leukemia-initiating cell activity requires calcineurin in T-cell acute lymphoblastic leukemia.ETO2-GLIS2 Hijacks Transcriptional Complexes to Drive Cellular Identity and Self-Renewal in Pediatric Acute Megakaryoblastic Leukemia.Architectural and functional heterogeneity of hematopoietic stem/progenitor cells in non-del(5q) myelodysplastic syndromes.The SCL/TAL1 Transcription Factor Represses the Stress Protein DDiT4/REDD1 in Human Hematopoietic Stem/Progenitor Cells.Saracatinib impairs maintenance of human T-ALL by targeting the LCK tyrosine kinase in cells displaying high level of lipid rafts.Impaired functionality and homing of Fancg-deficient hematopoietic stem cellsDynamics of Thymus-Colonizing Cells during Human DevelopmentEngraftment of human lymphoid cells into newborn SCID mice leads to graft-versushost disease
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P50
description
onderzoeker
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researcher
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հետազոտող
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Francoise Pflumio
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Francoise Pflumio
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Francoise Pflumio
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Francoise Pflumio
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Francoise Pflumio
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Francoise Pflumio
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Francoise Pflumio
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Francoise Pflumio
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Francoise Pflumio
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Francoise Pflumio
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Francoise Pflumio
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Francoise Pflumio
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Francoise Pflumio
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Francoise Pflumio
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Francoise Pflumio
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P106
P31
P496
0000-0001-8995-596X