Long terminal repeat sequences impart hematopoietic transformation properties to the myeloproliferative sarcoma virus.
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Viral transfer, transcription, and rescue of a selectable myeloproliferative sarcoma virus in embryonal cell lines: expression of the mos oncogeneTransformation of myelomonocytic cells by the avian myeloblastosis virus is determined by the v-myb oncogene, not by the unique long terminal repeats of the virus.Transplantable myeloproliferative disease induced in mice by an interleukin 6 retrovirus.Embryonic stem cell virus, a recombinant murine retrovirus with expression in embryonic stem cellsRestoration of surface IgM-mediated apoptosis in an anti-IgM-resistant variant of WEHI-231 lymphoma cells by HS1, a protein-tyrosine kinase substrate.Effects of retroviral vector design on expression of human adenosine deaminase in murine bone marrow transplant recipients engrafted with genetically modified cells.Functional analysis of a retroviral host-range mutant: altered long terminal repeat sequences allow expression in embryonal carcinoma cells.Autocrine stimulation after transfer of the granulocyte/macrophage colony-stimulating factor gene and autonomous growth are distinct but interdependent steps in the oncogenic pathwayRegulation and patterns of endogenous and exogenous gene expression during differentiation of embryonal carcinoma cells.Retroviral mutants efficiently expressed in embryonal carcinoma cellsMoloney murine sarcoma virus 349 induces Kaposi's sarcomalike lesions in Balb/c miceMultiple modifications in cis elements of the long terminal repeat of retroviral vectors lead to increased expression and decreased DNA methylation in embryonic carcinoma cells.Novel retroviral vectors for efficient expression of the multidrug resistance (mdr-1) gene in early hematopoietic cells.Unique long terminal repeat U3 sequences distinguish exogenous jaagsiekte sheep retroviruses associated with ovine pulmonary carcinoma from endogenous loci in the sheep genome.Consistent, persistent expression from modified retroviral vectors in murine hematopoietic stem cells.Abrogation of the requirement for feeder cell interaction and T cell receptor stimulation of lymphocytes infected with retroviral vectors.Increased probability of expression from modified retroviral vectors in embryonal stem cells and embryonal carcinoma cells.An internal deletion enhances the transcriptional activity of a recombinant retrovirus in hematopoietic cells in vivo.Selectable retrovirus vectors encoding Friend virus gp55 or erythropoietin induce polycythemia with different phenotypic expression and disease progression.A simple and efficient procedure for generating stable expression libraries by cDNA cloning in a retroviral vector.v-mos proteins encoded by myeloproliferative sarcoma virus and its ts159 mutant.The malignant histiocytosis sarcoma virus, a recombinant of Harvey murine sarcoma virus and Friend mink cell focus-forming virus, has acquired myeloid transformation specificity by alterations in the long terminal repeat.Comparison of expression in hemopoietic cells by retroviral vectors carrying two genes.Generation and characterization of a recombinant Moloney murine leukemia virus containing the v-myc oncogene of avian MC29 virus: in vitro transformation and in vivo pathogenesisTwo distinct sequence elements mediate retroviral gene expression in embryonal carcinoma cells.Hematologic disease induced in BALB/c mice by a bcr-abl retrovirus is influenced by the infection conditions.Insertional gene activation by lentiviral and gammaretroviral vectors.Induction of transforming growth factor beta 1 resistance by the E1A oncogene requires binding to a specific set of cellular proteins.Gene therapy: current status and future directions.Host cis-mediated extinction of a retrovirus permissive for expression in embryonal stem cells during differentiation.In vivo analysis of retroviral enhancer mutations in hematopoietic cells: SP1/EGR1 and ETS/GATA motifs contribute to long terminal repeat specificity.Production of replication-defective retrovirus by transient transfection of 293T cells.Sequential mutations in the interleukin-3 (IL3)/granulocyte-macrophage colony-stimulating factor/IL5 receptor beta-subunit genes are necessary for the complete conversion to growth autonomy mediated by a truncated beta C subunit.Determinants of retrovirus gene expression in embryonal carcinoma cells.Negative regulation of retrovirus expression in embryonal carcinoma cells mediated by an intragenic domain.A temperature-sensitive mutant of the myeloproliferative sarcoma virus, altered by a point mutation in the mos oncogene, has been modified as a selectable retroviral vector.Rates of mutation to growth factor autonomy and tumorigenicity differ in hematopoietic stem and precursor cells expressing the multilineage colony-stimulating factor gene.Distinct classes of factor-independent mutants can be isolated after retroviral mutagenesis of a human myeloid stem cell line.Targeted in vivo infection with a retroviral vector carrying the interleukin-3 (multi-CSF) gene leads to immortalization and leukemic transformation of primitive hematopoietic progenitor cells.Retrovirus mediated transfer and expression of GM-CSF in haematopoietic cells.
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Long terminal repeat sequences impart hematopoietic transformation properties to the myeloproliferative sarcoma virus.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on September 1985
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Long terminal repeat sequences ...... loproliferative sarcoma virus.
@en
Long terminal repeat sequences ...... loproliferative sarcoma virus.
@nl
type
label
Long terminal repeat sequences ...... loproliferative sarcoma virus.
@en
Long terminal repeat sequences ...... loproliferative sarcoma virus.
@nl
prefLabel
Long terminal repeat sequences ...... loproliferative sarcoma virus.
@en
Long terminal repeat sequences ...... loproliferative sarcoma virus.
@nl
P2093
P2860
P356
P1476
Long terminal repeat sequences ...... loproliferative sarcoma virus.
@en
P2093
P2860
P304
P356
10.1073/PNAS.82.17.5746
P407
P577
1985-09-01T00:00:00Z