Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus.
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Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans.Recent advances in understanding leptin signaling and leptin resistanceEmerging role of the brain in the homeostatic regulation of energy and glucose metabolismLeptin signaling and leptin resistanceAndrogen receptor (AR) pathophysiological roles in androgen-related diseases in skin, bone/muscle, metabolic syndrome and neuron/immune systems: lessons learned from mice lacking AR in specific cellsPresent status of clinical deployment of glucokinase activatorsCoordinated regulation by Shp2 tyrosine phosphatase of signaling events controlling insulin biosynthesis in pancreatic beta-cellsSilencing mitogen-activated protein 4 kinase 4 (MAP4K4) protects beta cells from tumor necrosis factor-alpha-induced decrease of IRS-2 and inhibition of glucose-stimulated insulin secretionSerpinB1 Promotes Pancreatic β Cell ProliferationThe role of insulin receptor substrate 2 in hypothalamic and beta cell function.CCL5/RANTES contributes to hypothalamic insulin signaling for systemic insulin responsiveness through CCR5.Insulin action in brain regulates systemic metabolism and brain function.Tissue-specific analysis of glycogen synthase kinase-3α (GSK-3α) in glucose metabolism: effect of strain variation.Leptin and insulin signaling in dopaminergic neurons: relationship between energy balance and reward system.Tissue-specific insulin signaling in the regulation of metabolism and aging.Brain deletion of insulin receptor substrate 2 disrupts hippocampal synaptic plasticity and metaplasticity.Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growthCytokines in the Progression of Pancreatic β-Cell DysfunctionConditional gene targeting in mouse pancreatic ß-Cells: analysis of ectopic Cre transgene expression in the brain.Bimodal effect on pancreatic β-cells of secretory products from normal or insulin-resistant human skeletal muscleImmunohistochemical localization of transient receptor potential vanilloid type 1 and insulin receptor substrate 2 and their co-localization with liver-related neurons in the hypothalamus and brainstem.Phosphatidylinositol 3-kinase p85alpha regulatory subunit gene PIK3R1 haplotype is associated with body fat and serum leptin in a female twin populationPancreatic signals controlling food intake; insulin, glucagon and amylinGlucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance.Inducible nitric-oxide synthase and nitric oxide donor decrease insulin receptor substrate-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta-cells: involvement of glycogen synthase kinase-3beta.Insm1 cooperates with Neurod1 and Foxa2 to maintain mature pancreatic β-cell functionA simple matter of life and death-the trials of postnatal Beta-cell mass regulationS6K1 controls pancreatic β cell size independently of intrauterine growth restrictionLeptin and the central nervous system control of glucose metabolism.IRS-2 Deficiency impairs NMDA receptor-dependent long-term potentiation.Central nervous system regulation of food intake.Insulin and Leptin Levels in Appropriate-for-Gestational-Age Infants of Diabetic Mother.Knockin of Cre Gene at Ins2 Locus Reveals No Cre Activity in Mouse Hypothalamic Neurons.On the role of IRS2 in the regulation of functional beta-cell mass.Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in ratsBrain expression of Cre recombinase driven by pancreas-specific promoters.Hypothalamic leptin regulation of energy homeostasis and glucose metabolism.Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanismsEffects of high-fat diet feeding on Znt8-null mice: differences between β-cell and global knockout of Znt8Growth factor control of pancreatic islet regeneration and function
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Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on October 2004
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus.
@en
Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus.
@nl
type
label
Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus.
@en
Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus.
@nl
prefLabel
Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus.
@en
Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus.
@nl
P2093
P2860
P356
P1476
Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus.
@en
P2093
Hidemi Satoh
Iseki Takamoto
Kazuyuki Tobe
Masao Moroi
Miki Okada-Iwabu
Naoto Kubota
Osamu Ezaki
Ryo Suzuki
Ryozo Nagai
Takashi Kadowaki
P2860
P304
P356
10.1172/JCI21484
P407
P50
P577
2004-10-01T00:00:00Z