Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus. - Wikidata - wikimedia - TriplyDB

Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus.

Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus.

http://www.wikidata.org/entity/Q37532741

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Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans.Recent advances in understanding leptin signaling and leptin resistance Emerging role of the brain in the homeostatic regulation of energy and glucose metabolism Leptin signaling and leptin resistance Androgen receptor (AR) pathophysiological roles in androgen-related diseases in skin, bone/muscle, metabolic syndrome and neuron/immune systems: lessons learned from mice lacking AR in specific cells Present status of clinical deployment of glucokinase activators Coordinated regulation by Shp2 tyrosine phosphatase of signaling events controlling insulin biosynthesis in pancreatic beta-cells Silencing mitogen-activated protein 4 kinase 4 (MAP4K4) protects beta cells from tumor necrosis factor-alpha-induced decrease of IRS-2 and inhibition of glucose-stimulated insulin secretion SerpinB1 Promotes Pancreatic β Cell Proliferation The role of insulin receptor substrate 2 in hypothalamic and beta cell function.CCL5/RANTES contributes to hypothalamic insulin signaling for systemic insulin responsiveness through CCR5.Insulin action in brain regulates systemic metabolism and brain function.Tissue-specific analysis of glycogen synthase kinase-3α (GSK-3α) in glucose metabolism: effect of strain variation.Leptin and insulin signaling in dopaminergic neurons: relationship between energy balance and reward system.Tissue-specific insulin signaling in the regulation of metabolism and aging.Brain deletion of insulin receptor substrate 2 disrupts hippocampal synaptic plasticity and metaplasticity.Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth Cytokines in the Progression of Pancreatic β-Cell Dysfunction Conditional gene targeting in mouse pancreatic ß-Cells: analysis of ectopic Cre transgene expression in the brain.Bimodal effect on pancreatic β-cells of secretory products from normal or insulin-resistant human skeletal muscle Immunohistochemical localization of transient receptor potential vanilloid type 1 and insulin receptor substrate 2 and their co-localization with liver-related neurons in the hypothalamus and brainstem.Phosphatidylinositol 3-kinase p85alpha regulatory subunit gene PIK3R1 haplotype is associated with body fat and serum leptin in a female twin population Pancreatic signals controlling food intake; insulin, glucagon and amylin Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance.Inducible nitric-oxide synthase and nitric oxide donor decrease insulin receptor substrate-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta-cells: involvement of glycogen synthase kinase-3beta.Insm1 cooperates with Neurod1 and Foxa2 to maintain mature pancreatic β-cell function A simple matter of life and death-the trials of postnatal Beta-cell mass regulation S6K1 controls pancreatic β cell size independently of intrauterine growth restriction Leptin and the central nervous system control of glucose metabolism.IRS-2 Deficiency impairs NMDA receptor-dependent long-term potentiation.Central nervous system regulation of food intake.Insulin and Leptin Levels in Appropriate-for-Gestational-Age Infants of Diabetic Mother.Knockin of Cre Gene at Ins2 Locus Reveals No Cre Activity in Mouse Hypothalamic Neurons.On the role of IRS2 in the regulation of functional beta-cell mass.Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats Brain expression of Cre recombinase driven by pancreas-specific promoters.Hypothalamic leptin regulation of energy homeostasis and glucose metabolism.Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms Effects of high-fat diet feeding on Znt8-null mice: differences between β-cell and global knockout of Znt8 Growth factor control of pancreatic islet regeneration and function

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Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus.

http://www.wikidata.org/entity/Q37532741

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on October 2004

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus.

@en

Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus.

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type

label

Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus.

@en

Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus.

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prefLabel

Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus.

@en

Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus.

@nl

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Journal of Clinical Investigation

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Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus.

@en

P2093

Hidemi Satoh

http://www.w3.org/2001/XMLSchema#string

Iseki Takamoto

http://www.w3.org/2001/XMLSchema#string

Kazuyuki Tobe

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Masao Moroi

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Miki Okada-Iwabu

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Naoto Kubota

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Osamu Ezaki

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Ryo Suzuki

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Ryozo Nagai

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Takashi Kadowaki

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P2860

Insulin signalling and the regulation of glucose and lipid metabolism

Disruption of IRS-2 causes type 2 diabetes in mice

The IRS-signalling system: a network of docking proteins that mediate insulin action

The Gly972-->Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic beta cells

Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease

Disruption of adiponectin causes insulin resistance and neointimal formation

PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum

Cellular mechanisms of insulin resistance

PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance

Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance

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917-927

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scholarly article

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10.1172/JCI21484

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7

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15467830

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518663

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