Rare, nonsynonymous variant in the smooth muscle-specific isoform of myosin heavy chain, MYH11, R247C, alters force generation in the aorta and phenotype of smooth muscle cells.
about
Myh11(R247C/R247C) mutations increase thoracic aorta vulnerability to intramural damage despite a general biomechanical adaptivity.Differentiation defect in neural crest-derived smooth muscle cells in patients with aortopathy associated with bicuspid aortic valves.Vascular disease-causing mutation R258C in ACTA2 disrupts actin dynamics and interaction with myosinSex-dependent genetic effects on immune responses to a parasitic nematode.Salt-sensitive hypertension and cardiac hypertrophy in transgenic mice expressing a corin variant identified in blacksMyocardin is required for maintenance of vascular and visceral smooth muscle homeostasis during postnatal developmentRole of mechanotransduction in vascular biology: focus on thoracic aortic aneurysms and dissections.First genetic analysis of aneurysm genes in familial and sporadic abdominal aortic aneurysm.Graded effects of unregulated smooth muscle myosin on intestinal architecture, intestinal motility and vascular function in zebrafishSmooth muscle hyperplasia due to loss of smooth muscle α-actin is driven by activation of focal adhesion kinase, altered p53 localization and increased levels of platelet-derived growth factor receptor-β.Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis.Review of molecular and mechanical interactions in the aortic valve and aorta: implications for the shared pathogenesis of aortic valve disease and aortopathy.Comparison of 10 murine models reveals a distinct biomechanical phenotype in thoracic aortic aneurysms.Adult vascular smooth muscle cells in culture express neural stem cell markers typical of resident multipotent vascular stem cells.Altered Smooth Muscle Cell Force Generation as a Driver of Thoracic Aortic Aneurysms and Dissections.Emerging roles for vascular smooth muscle cell exosomes in calcification and coagulation.Distinct molecular subtypes of uterine leiomyosarcoma respond differently to chemotherapy treatment.Genes Associated with Thoracic Aortic Aneurysm and Dissection: An Update and Clinical Implications.Abnormal mechanosensing and cofilin activation promote the progression of ascending aortic aneurysms in mice.The genetics and genomics of thoracic aortic disease.Human Tonic and Phasic Smooth Muscle Myosin Isoforms Are Unresponsive to the Loop 1 Insert.The effects of elastic fiber protein insufficiency and treatment on the modulus of arterial smooth muscle cellsMMP17/MT4-MMP and thoracic aortic aneurysms: OPNing new potential for effective treatment.Variation of mechanical properties and quantitative proteomics of VSMC along the arterial tree.Biomechanical Phenotyping of the Murine Aorta: What Is the Best Control?Crossing Bridges between Extra- and Intra-Cellular Events in Thoracic Aortic Aneurysms.Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis.Rho kinase activity governs arteriolar myogenic depolarization.Genetic approaches to identify pathological limitations in aortic smooth muscle contraction.The dominant protein phosphatase PP1c isoform in smooth muscle cells, PP1cβ, is essential for smooth muscle contraction
P2860
Q27310169-52FFD4D5-9600-4899-9034-7473FA62B31DQ27311656-2D2C667E-F58D-42DF-BD9A-CA3556DF83DBQ27322453-8F991ECD-D306-42AD-BE1A-592557F4D82AQ33616415-F24D3498-55E8-493E-A35F-E22D22FE9E1FQ34300359-DAF53AD1-EA7E-4296-8F38-37D7CAC5EBB8Q35377710-1559A095-5A3A-4D1E-9B72-2EAAC9E5B607Q35571996-B5444E76-6F4A-4819-A3F9-DF770DD80D07Q35829553-3971F846-D1BD-4E02-8479-66B4E5A3EE08Q36967508-7883236F-3C14-4D2F-8DC5-AD02C8D5BA31Q36975163-043F7A12-1BB4-4AE7-8AEF-45B6EDAC71CEQ37524234-CF2098C2-0759-40C6-BF23-06522600E24EQ38269616-85E21EE9-B372-4EBA-B974-AE84F65AB803Q38793690-C15D7303-B40F-45F3-8BA5-B496ED7448DFQ38978322-5134AF36-13EA-412B-A01C-D9DE1B7C004EQ39017923-A8B8C1E9-8677-4710-A567-A547BAA7E47BQ40006523-5433E609-2BCD-4BBE-92E3-F3C4EBD190A1Q41279692-74DA3D3E-ABD0-4F1B-9F50-013EF7F7BC99Q41513957-36B1639C-A960-4FA6-A0FC-A2CC0663E24AQ41525208-0D4719B9-0C1A-4CD9-B1EE-BC2A7E373FFEQ41816805-9481D55C-E69D-434D-B2ED-0408FA0F605AQ41985433-596CCD0F-215A-441E-BE75-CE4D42006D23Q42115279-E0A6E3A1-965D-44D7-80D6-C04DB1113B67Q42353260-4AD30219-2F47-4178-8124-12A0676BBA37Q42450978-FE7D8117-F7DD-4151-8453-990D269BD2FDQ47375871-6A00D788-EA1B-47D7-ADAE-025CFC3C41DBQ47751472-0CA81FE7-A4EB-4B27-961B-295B33B117DAQ48152427-B3E93B0E-C78D-4668-ACAB-FC1DB25D7B2EQ49157136-49C59BF3-6928-42FA-B3F7-845F8BE1CB4BQ51745896-BF43027C-932A-4DA1-BB39-F9EE7ED564B8Q58110354-992CB0D1-8B7E-421D-9A30-B9A2356F8584
P2860
Rare, nonsynonymous variant in the smooth muscle-specific isoform of myosin heavy chain, MYH11, R247C, alters force generation in the aorta and phenotype of smooth muscle cells.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 17 April 2012
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Rare, nonsynonymous variant in ...... notype of smooth muscle cells.
@en
Rare, nonsynonymous variant in ...... notype of smooth muscle cells.
@nl
type
label
Rare, nonsynonymous variant in ...... notype of smooth muscle cells.
@en
Rare, nonsynonymous variant in ...... notype of smooth muscle cells.
@nl
prefLabel
Rare, nonsynonymous variant in ...... notype of smooth muscle cells.
@en
Rare, nonsynonymous variant in ...... notype of smooth muscle cells.
@nl
P2093
P2860
P1433
P1476
Rare, nonsynonymous variant in ...... notype of smooth muscle cells.
@en
P2093
Callie S Kwartler
Dianna M Milewicz
H Lee Sweeney
James T Stull
Jian Huang
Katerina L Byanova
Kristine E Kamm
Limin Gong
Shao-Qing Kuang
P2860
P304
P356
10.1161/CIRCRESAHA.111.261743
P577
2012-04-17T00:00:00Z