Cellular and Biochemical Mechanisms of the Retroviral Restriction Factor SAMHD1.
about
Regulation of deoxynucleotide metabolism in cancer: novel mechanisms and therapeutic implicationsIdentification of cellular proteins interacting with the retroviral restriction factor SAMHD1Structural basis of cellular dNTP regulation by SAMHD1.Structural basis of allosteric activation of sterile α motif and histidine-aspartate domain-containing protein 1 (SAMHD1) by nucleoside triphosphates.Role of myeloid cells in HIV-1-host interplay.Phosphorylation of mouse SAMHD1 regulates its restriction of human immunodeficiency virus type 1 infection, but not murine leukemia virus infection.The ubiquitin ligase TRIM27 functions as a host restriction factor antagonized by Mycobacterium tuberculosis PtpA during mycobacterial infection.SAMHD1 controls cell cycle status, apoptosis and HIV-1 infection in monocytic THP-1 cells.SAMHD1's protein expression profile in humans.HIV-2 infects resting CD4+ T cells but not monocyte-derived dendritic cells.A Cyclin-binding Motif in Human SAMHD1 Is Required for Its HIV-1 Restriction, dNTPase Activity, Tetramer Formation, and Efficient Phosphorylation.SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-κB and interferon pathways.SAMHD1 Impairs HIV-1 Gene Expression and Negatively Modulates Reactivation of Viral Latency in CD4+ T-cells.
P2860
Q26785350-10394384-24FA-4F28-BD13-4B988B1CB41CQ33602815-360208B9-11F6-43D8-901E-EBCB4BA7C211Q34383850-760084F1-5B74-4EA4-A85F-32651E664AE8Q34552616-28375E75-C5A4-4652-94D2-9C54AAE59851Q35196505-40696C4B-553A-462D-A75B-91311330BDA2Q36372744-6CD77EF1-5ED7-4D68-9265-C0D7F5B8A795Q37307061-DFAC96A4-42EE-426F-9D28-08E7D1C77FFAQ38770662-8656E6FB-D276-405C-8806-D0F2B557E24FQ38913628-1DD675C3-E738-4AA4-A707-3BA854654D26Q41548052-7430C972-5B88-431E-8C25-E0816F4FC857Q50101944-D5C55C61-37B6-452C-B536-2048AFE65E2FQ52611929-7D99E4CC-7316-474D-8B03-8452A67265DBQ55239050-90FA19C9-8222-4206-8CC4-5123F6F837A7
P2860
Cellular and Biochemical Mechanisms of the Retroviral Restriction Factor SAMHD1.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on July 2013
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Cellular and Biochemical Mechanisms of the Retroviral Restriction Factor SAMHD1.
@en
Cellular and Biochemical Mechanisms of the Retroviral Restriction Factor SAMHD1.
@nl
type
label
Cellular and Biochemical Mechanisms of the Retroviral Restriction Factor SAMHD1.
@en
Cellular and Biochemical Mechanisms of the Retroviral Restriction Factor SAMHD1.
@nl
prefLabel
Cellular and Biochemical Mechanisms of the Retroviral Restriction Factor SAMHD1.
@en
Cellular and Biochemical Mechanisms of the Retroviral Restriction Factor SAMHD1.
@nl
P2860
P356
P1433
P1476
Cellular and Biochemical Mechanisms of the Retroviral Restriction Factor SAMHD1
@en
P2093
P2860
P356
10.1155/2013/728392
P50
P577
2013-07-01T00:00:00Z