A truncated mutant (residues 58-140) of the hepatitis B virus X protein retains transactivation function.
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The X protein of hepatitis B virus binds to the F box protein Skp2 and inhibits the ubiquitination and proteasomal degradation of c-MycAkt augments the oncogenic potential of the HBx protein of hepatitis B virus by phosphorylationHepatitis B Virus X Protein and HepatocarcinogenesisHepatitis B virus, HBx mutants and their role in hepatocellular carcinomaThe HBx oncoprotein of hepatitis B virus deregulates the cell cycle by promoting the intracellular accumulation and re-compartmentalization of the cellular deubiquitinase USP37.Different regions of hepatitis B virus X protein are required for enhancement of bZip-mediated transactivation versus transrepression.Duck hepatitis B virus expresses a regulatory HBx-like protein from a hidden open reading frameSustained activation of mitogen-activated protein kinases and activator protein 1 by the hepatitis B virus X protein in mouse hepatocytes in vivo.Interaction of Hepatitis B virus with cellular processes in liver carcinogenesis.Identification of hepatitis B virus X gene variants between hepatocellular carcinoma tissues and pericarcinoma liver tissues in Eastern ChinaAccurately mapping the location of the binding site for the interaction between hepatitis B virus X protein and cytochrome c oxidase III.Interaction of the UV-damaged DNA-binding protein with hepatitis B virus X protein is conserved among mammalian hepadnaviruses and restricted to transactivation-proficient X-insertion mutantsInfluence of hepatitis B virus X and core promoter mutations on hepatocellular carcinoma among patients infected with subgenotype C2.The G1 phase E3 ubiquitin ligase TRUSS that gets deregulated in human cancers is a novel substrate of the S-phase E3 ubiquitin ligase Skp2.Viral replication modulated by synthetic peptide derived from hepatitis B virus X proteinRapid and Accurate Determination of Lipopolysaccharide O-Antigen Types in Klebsiella pneumoniae with a Novel PCR-Based O-Genotyping MethodHepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis.Hepatitis B virus subgenotype C2- and B2-associated mutation patterns may be responsible for liver cirrhosis and hepatocellular carcinoma, respectively.Deubiquitylation of hepatitis B virus X protein (HBx) by ubiquitin-specific peptidase 15 (USP15) increases HBx stability and its transactivation activity.HBx mutants differentially affect the activation of hypoxia-inducible factor-1α in hepatocellular carcinoma.Hepatitis B virus X gene and hepatocarcinogenesis.The molecular and pathophysiological implications of hepatitis B X antigen in chronic hepatitis B virus infection.An internal segment (residues 58-119) of the hepatitis B virus X protein is sufficient to activate MAP kinase pathways in mouse liver.HBx-dependent cell cycle deregulation involves interaction with cyclin E/A-cdk2 complex and destabilization of p27Kip1.HBx protein of hepatitis B virus activates Jak1-STAT signaling.Wild type HBx and truncated HBx: Pleiotropic regulators driving sequential genetic and epigenetic steps of hepatocarcinogenesis and progression of HBV-associated neoplasms.HBV DNA Integration: Molecular Mechanisms and Clinical ImplicationsDissecting the pleiotropic actions of HBx mutants against hypoxia in hepatocellular carcinoma.Key elements of the RNAi pathway are regulated by hepatitis B virus replication and HBx acts as a viral suppressor of RNA silencing.Sequence specific cleavage of the HIV-1 coreceptor CCR5 gene by a hammer-head ribozyme and a DNA-enzyme: inhibition of the coreceptor function by DNA-enzyme.The mitogenic function of hepatitis B virus X protein resides within amino acids 51 to 140 and is modulated by N- and C-terminal regulatory regions.Hepatitis B virus X protein enhances activation of nuclear factor κB through interaction with valosin-containing protein.Expression of mutated hepatitis B virus X genes in human hepatocellular carcinomas.Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-kappa B via oxidative stress.c-Fos is a mediator of the c-myc-induced apoptotic signaling in serum-deprived hepatoma cells via the p38 mitogen-activated protein kinase pathway.Inhibition of hepatitis B virus X gene expression by novel DNA enzymes.UVDDB p127-binding modulates activities and intracellular distribution of hepatitis B virus X protein.The viral transactivator HBx protein exhibits a high potential for regulation via phosphorylation through an evolutionarily conserved mechanism.HBx protein of hepatitis B virus promotes reinitiation of DNA replication by regulating expression and intracellular stability of replication licensing factor CDC6Specific inhibition of gene expression and transactivation functions of hepatitis B virus X protein and c-myc by small interfering RNAs.
P2860
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P2860
A truncated mutant (residues 58-140) of the hepatitis B virus X protein retains transactivation function.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on May 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
A truncated mutant (residues 5 ...... ains transactivation function.
@en
A truncated mutant
@nl
type
label
A truncated mutant (residues 5 ...... ains transactivation function.
@en
A truncated mutant
@nl
prefLabel
A truncated mutant (residues 5 ...... ains transactivation function.
@en
A truncated mutant
@nl
P2093
P2860
P356
P1476
A truncated mutant (residues 5 ...... ains transactivation function.
@en
P2093
P2860
P304
P356
10.1073/PNAS.93.11.5647
P407
P577
1996-05-01T00:00:00Z