A single active site residue directs oxygenation stereospecificity in lipoxygenases: stereocontrol is linked to the position of oxygenation.
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LC/MS analysis of cardiolipins in substantia nigra and plasma of rotenone-treated rats: implication for mitochondrial dysfunction in Parkinson's diseaseDioxygenase activity of epidermal lipoxygenase-3 unveiled: typical and atypical features of its catalytic activity with natural and synthetic polyunsaturated fatty acidsLipoxygenases mediate the effect of essential fatty acid in skin barrier formation: a proposed role in releasing omega-hydroxyceramide for construction of the corneocyte lipid envelopeThe structure of human 15-lipoxygenase-2 with a substrate mimicThe 1.85 Å Structure of an 8 R -Lipoxygenase Suggests a General Model for Lipoxygenase Product SpecificityStructure and interaction with phospholipids of a prokaryotic lipoxygenase from Pseudomonas aeruginosaCrystal structure of 12-lipoxygenase catalytic-domain-inhibitor complex identifies a substrate-binding channel for catalysisHeterologous Expression and Biochemical Characterization of Two Lipoxygenases in Oriental Melon, Cucumis melo var. makuwa MakinoA dual positional specific lipoxygenase functions in the generation of flavor compounds during climacteric ripening of appleLipoxygenase pathways in Homo neanderthalensis: functional comparison with Homo sapiens isoformsThe structural basis for specificity in lipoxygenase catalysis.Bacterial lipoxygenases, a new subfamily of enzymes? A phylogenetic approach.Crystal structure of a lipoxygenase in complex with substrate: the arachidonic acid-binding site of 8R-lipoxygenase.On the role of molecular oxygen in lipoxygenase activation: comparison and contrast of epidermal lipoxygenase-3 with soybean lipoxygenase-1.An iron 13S-lipoxygenase with an α-linolenic acid specific hydroperoxidase activity from Fusarium oxysporum.Investigation of substrate binding and product stereochemistry issues in two linoleate 9-lipoxygenasesThematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology.Targeted knock-down of a structurally atypical zebrafish 12S-lipoxygenase leads to severe impairment of embryonic developmentApplications of stereospecifically-labeled Fatty acids in oxygenase and desaturase biochemistryEffect of fish oil on levels of R- and S-enantiomers of 5-, 12-, and 15-hydroxyeicosatetraenoic acids in mouse colonic mucosa.Identification of the Substrate Access Portal of 5-LipoxygenaseControl of oxygenation in lipoxygenase and cyclooxygenase catalysisSubstrate specificity changes for human reticulocyte and epithelial 15-lipoxygenases reveal allosteric product regulation.Functional characterization of genetic enzyme variations in human lipoxygenases.Oxidative metabolism of lipoamino acids and vanilloids by lipoxygenases and cyclooxygenases.On the relationships of substrate orientation, hydrogen abstraction, and product stereochemistry in single and double dioxygenations by soybean lipoxygenase-1 and its Ala542Gly mutant.Industrial potential of lipoxygenases.Stereocontrol of arachidonic acid oxygenation by vertebrate lipoxygenases: newly cloned zebrafish lipoxygenase 1 does not follow the Ala-versus-Gly concept.Secretion of two novel enzymes, manganese 9S-lipoxygenase and epoxy alcohol synthase, by the rice pathogen Magnaporthe salvinii.Membrane-dependent Activities of Human 15-LOX-2 and Its Murine Counterpart: IMPLICATIONS FOR MURINE MODELS OF ATHEROSCLEROSISCharacterization of an omega-6 linoleate lipoxygenase from Burkholderia thailandensis and its application in the production of 13-hydroxyoctadecadienoic acid.Purification, crystallization and preliminary X-ray diffraction analysis of pathogen-inducible oxygenase (PIOX) from Oryza sativa.Applicability of the triad concept for the positional specificity of mammalian lipoxygenases.Manganese lipoxygenase of F. oxysporum and the structural basis for biosynthesis of distinct 11-hydroperoxy stereoisomers.Crystal structure of linoleate 13R-manganese lipoxygenase in complex with an adhesion protein.Lipoxygenase 2 from Cyanothece sp. controls dioxygen insertion by steric shielding and substrate fixation.Catalytic convergence of manganese and iron lipoxygenases by replacement of a single amino acid.Dynamic behavior of fatty acid spin labels within a binding site of soybean lipoxygenase-1.Omega-3 fatty acids are oxygenated at the n-7 carbon by the lipoxygenase domain of a fusion protein in the cyanobacterium Acaryochloris marina.Crystal structure of a lipoxygenase from Cyanothece sp. may reveal novel features for substrate acquisition.
P2860
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P2860
A single active site residue directs oxygenation stereospecificity in lipoxygenases: stereocontrol is linked to the position of oxygenation.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 20 October 2004
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
A single active site residue d ...... o the position of oxygenation.
@en
A single active site residue d ...... o the position of oxygenation.
@nl
type
label
A single active site residue d ...... o the position of oxygenation.
@en
A single active site residue d ...... o the position of oxygenation.
@nl
prefLabel
A single active site residue d ...... o the position of oxygenation.
@en
A single active site residue d ...... o the position of oxygenation.
@nl
P2860
P356
P1476
A single active site residue d ...... o the position of oxygenation.
@en
P2093
Alan R Brash
Gianguido Coffa
P2860
P304
15579-15584
P356
10.1073/PNAS.0406727101
P407
P577
2004-10-20T00:00:00Z