Apoptosis and autophagy: BIM as a mediator of tumour cell death in response to oncogene-targeted therapeutics.
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Regulation of Bim in Health and DiseaseTranscriptional repression of Bim by a novel YY1-RelA complex is essential for the survival and growth of Multiple MyelomaProteasomal degradation of Mcl-1 by maritoclax induces apoptosis and enhances the efficacy of ABT-737 in melanoma cellsSuberoylanilide hydroxamic acid (SAHA) and cladribine synergistically induce apoptosis in NK-LGL leukaemia.Bauerenol, a triterpenoid from Indian Suregada angustifolia: Induces reactive oxygen species-mediated P38MAPK activation and apoptosis in human hepatocellular carcinoma (HepG2) cells.BIMEL is a key effector molecule in oxidative stress-mediated apoptosis in acute myeloid leukemia cells when combined with arsenic trioxide and buthionine sulfoximineBryostatin analogue-induced apoptosis in mantle cell lymphoma cell linesCell death and inflammatory bowel diseases: apoptosis, necrosis, and autophagy in the intestinal epithelium.Critical role of p53 upregulated modulator of apoptosis in benzyl isothiocyanate-induced apoptotic cell deathTargeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway.Transcriptome profiling of CTLs regulated by rapamycin using RNA-SeqA Bim-targeting strategy overcomes adaptive bortezomib resistance in myeloma through a novel link between autophagy and apoptosisAntitumor activity of S116836, a novel tyrosine kinase inhibitor, against imatinib-resistant FIP1L1-PDGFRα-expressing cellsRegulation and Function of the RasGRP Family of Ras Activators in Blood CellsNovel microRNA prosurvival cocktail for improving engraftment and function of cardiac progenitor cell transplantation.Increased expression of the pro-apoptotic protein BIM, a mechanism for cAMP/protein kinase A (PKA)-induced apoptosis of immature T cells.Bim contributes to phenethyl isothiocyanate-induced apoptosis in breast cancer cells.Paclitaxel resistance is associated with switch from apoptotic to autophagic cell death in MCF-7 breast cancer cellsKLF9 is a novel transcriptional regulator of bortezomib- and LBH589-induced apoptosis in multiple myeloma cells.Induction of brain tumor stem cell apoptosis by FTY720: a potential therapeutic agent for glioblastomaMir-192 suppresses apoptosis and promotes proliferation in esophageal aquamous cell caicinoma by targeting Bim.Identification of a Dual Inhibitor of Janus Kinase 2 (JAK2) and p70 Ribosomal S6 Kinase1 (S6K1) Pathways.CDK inhibitors upregulate BH3-only proteins to sensitize human myeloma cells to BH3 mimetic therapies.Chloroquine inhibits hepatocellular carcinoma cell growth in vitro and in vivo.The relationship between BIM deletion polymorphism and clinical significance of epidermal growth factor receptor-mutated non-small cell lung cancer patients with epidermal growth factor receptor-tyrosine kinase inhibitor therapy: a meta-analysis.Targeting ERK1/2-bim signaling cascades by BH3-mimetic ABT-737 as an alternative therapeutic strategy for oral cancer.MicroRNAs and Glucocorticoid-Induced Apoptosis in Lymphoid MalignanciesMAPK pathway activation leads to Bim loss and histone deacetylase inhibitor resistance: rationale to combine romidepsin with an MEK inhibitor.BIM mediates oncogene inactivation-induced apoptosis in multiple transgenic mouse models of acute lymphoblastic leukemia.Chemotherapy resistance and metastasis-promoting effects of thyroid hormone in hepatocarcinoma cells are mediated by suppression of FoxO1 and Bim pathway.Knockdown of miR-214 promotes apoptosis and inhibits cell proliferation in nasopharyngeal carcinomaThe Nedd8-activating enzyme inhibitor MLN4924 thwarts microenvironment-driven NF-κB activation and induces apoptosis in chronic lymphocytic leukemia B cells.Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways.Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy.Mechanisms of acquired resistance to ERK1/2 pathway inhibitors.Wnt/β-catenin signaling and AXIN1 regulate apoptosis triggered by inhibition of the mutant kinase BRAFV600E in human melanoma.Efficacy of an HSP90 inhibitor, ganetespib, in preclinical thyroid cancer models.Identification of novel target genes specifically activated by deregulated E2F in human normal fibroblasts.miR-181a mediates TGF-β-induced hepatocyte EMT and is dysregulated in cirrhosis and hepatocellular cancer.Dual inhibition of MEK1/2 and EGFR synergistically induces caspase-3-dependent apoptosis in EGFR inhibitor-resistant lung cancer cells via BIM upregulation.
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Apoptosis and autophagy: BIM as a mediator of tumour cell death in response to oncogene-targeted therapeutics.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 29 September 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Apoptosis and autophagy: BIM a ...... ncogene-targeted therapeutics.
@en
Apoptosis and autophagy: BIM a ...... ncogene-targeted therapeutics.
@nl
type
label
Apoptosis and autophagy: BIM a ...... ncogene-targeted therapeutics.
@en
Apoptosis and autophagy: BIM a ...... ncogene-targeted therapeutics.
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prefLabel
Apoptosis and autophagy: BIM a ...... ncogene-targeted therapeutics.
@en
Apoptosis and autophagy: BIM a ...... ncogene-targeted therapeutics.
@nl
P2093
P2860
P1433
P1476
Apoptosis and autophagy: BIM a ...... ncogene-targeted therapeutics.
@en
P2093
Annette S Gillings
Ceri M Wiggins
Kathryn Balmanno
Mark Johnson
Simon J Cook
P2860
P304
P356
10.1111/J.1742-4658.2009.07329.X
P407
P577
2009-09-29T00:00:00Z