Disrupting polyamine homeostasis as a therapeutic strategy for neuroblastoma.
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Translational development of difluoromethylornithine (DFMO) for the treatment of neuroblastomaStructure of Prokaryotic Polyamine Deacetylase Reveals Evolutionary Functional Relationships with Eukaryotic Histone Deacetylases,Structural Insight into DFMO Resistant Ornithine Decarboxylase from Entamoeba histolytica: An Inkling to Adaptive EvolutionInhibition of mTOR-kinase destabilizes MYCN and is a potential therapy for MYCN-dependent tumorsNovel interaction of ornithine decarboxylase with sepiapterin reductase regulates neuroblastoma cell proliferation.Targeting ornithine decarboxylase for the prevention of nonmelanoma skin cancer in humans.Initial testing (stage 1) of the polyamine analog PG11047 by the pediatric preclinical testing program.Evidence of a role for antizyme and antizyme inhibitor as regulators of human cancer.Neuroblastoma: molecular pathogenesis and therapy.A Phase I Trial of DFMO Targeting Polyamine Addiction in Patients with Relapsed/Refractory NeuroblastomaNeuroblastoma treatment in the post-genomic era.Polyamines are oncometabolites that regulate the LIN28/let-7 pathway in colorectal cancer cells.Consumption of Red/Processed Meat and Colorectal Carcinoma: Possible Mechanisms Underlying the Significant Association.Genetic discoveries and treatment advances in neuroblastoma.Difluoromethylornithine in cancer: new advances.Epibrassinolide-induced apoptosis regardless of p53 expression via activating polyamine catabolic machinery, a common target for androgen sensitive and insensitive prostate cancer cells.Polyamine depletion enhances the roscovitine-induced apoptosis through the activation of mitochondria in HCT116 colon carcinoma cells.Polyamine pathway inhibition as a novel therapeutic approach to treating neuroblastoma.Polyamines directly promote antizyme-mediated degradation of ornithine decarboxylase by the proteasome.Alpha-Difluoromethylornithine, an Irreversible Inhibitor of Polyamine Biosynthesis, as a Therapeutic Strategy against Hyperproliferative and Infectious Diseases.Myc, Oncogenic Protein Translation, and the Role of Polyamines.Dual role of HDAC10 in lysosomal exocytosis and DNA repair promotes neuroblastoma chemoresistance.
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Disrupting polyamine homeostasis as a therapeutic strategy for neuroblastoma.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 29 September 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Disrupting polyamine homeostasis as a therapeutic strategy for neuroblastoma.
@en
Disrupting polyamine homeostasis as a therapeutic strategy for neuroblastoma.
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type
label
Disrupting polyamine homeostasis as a therapeutic strategy for neuroblastoma.
@en
Disrupting polyamine homeostasis as a therapeutic strategy for neuroblastoma.
@nl
prefLabel
Disrupting polyamine homeostasis as a therapeutic strategy for neuroblastoma.
@en
Disrupting polyamine homeostasis as a therapeutic strategy for neuroblastoma.
@nl
P2860
P1476
Disrupting polyamine homeostasis as a therapeutic strategy for neuroblastoma.
@en
P2093
Michael D Hogarty
Nicholas F Evageliou
P2860
P304
P356
10.1158/1078-0432.CCR-08-3213
P407
P577
2009-09-29T00:00:00Z