EZH2 expands breast stem cells through activation of NOTCH1 signaling. - Wikidata - wikimedia - TriplyDB

EZH2 expands breast stem cells through activation of NOTCH1 signaling.

EZH2 expands breast stem cells through activation of NOTCH1 signaling.

http://www.wikidata.org/entity/Q37612687

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Targeting EZH2 in cancer Emerging Transcriptional Mechanisms in the Regulation of Epithelial to Mesenchymal Transition and Cellular Plasticity in the Kidney EZH2 in normal hematopoiesis and hematological malignancies Diverse involvement of EZH2 in cancer epigenetics Hsp90 inhibition destabilizes Ezh2 protein in alloreactive T cells and reduces graft-versus-host disease in mice Role of EZH2 in cancer stem cells: from biological insight to a therapeutic target.Functional and therapeutic significance of EZH2 in urological cancers Regulation and Role of EZH2 in Cancer Notch2 activation is protective against anticancer effects of zerumbone in human breast cancer cells The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors.The methyltransferase EZH2 is not required for mammary cancer development, although high EZH2 and low H3K27me3 correlate with poor prognosis of ER-positive breast cancers The role of polycomb group protein Bmi-1 and Notch4 in breast cancer stem cell inhibition by benzyl isothiocyanate.Intra-tumour signalling entropy determines clinical outcome in breast and lung cancer.Hidden among the crowd: differential DNA methylation-expression correlations in cancer occur at important oncogenic pathways Selective inhibition of EZH2 by ZLD1039 blocks H3K27 methylation and leads to potent anti-tumor activity in breast cancer.Phosphorylation of EZH2 at T416 by CDK2 contributes to the malignancy of triple negative breast cancers.Significance of EZH2 expression in canine mammary tumors.Loss of EZH2 results in precocious mammary gland development and activation of STAT5-dependent genes.Non-Canonical EZH2 Transcriptionally Activates RelB in Triple Negative Breast Cancer A Gene Regulatory Program in Human Breast Cancer Honokiol inhibits bladder tumor growth by suppressing EZH2/miR-143 axis.EZH2 overexpression in different immunophenotypes of breast carcinoma and association with clinicopathologic features.A positive role for polycomb in transcriptional regulation via H4K20me1.HIFI-α activation underlies a functional switch in the paradoxical role of Ezh2/PRC2 in breast cancer.Benzyl butyl phthalate promotes breast cancer stem cell expansion via SPHK1/S1P/S1PR3 signaling.Tyrosine kinase discoidin domain receptors DDR1 and DDR2 are coordinately deregulated in triple-negative breast cancer.EZH2 protein expression in normal breast epithelium and risk of breast cancer: results from the Nurses' Health Studies.Novel function of MDA-9/Syntenin (SDCBP) as a regulator of survival and stemness in glioma stem cells.Blocking EZH2 methylation transferase activity by GSK126 decreases stem cell-like myeloma cells.Regulation of breast cancer stem cell features.Mutation spectra of histone methyltransferases with canonical SET domains and EZH2-targeted therapy.Mining the epigenetic landscape of tissue polarity in search of new targets for cancer therapy.Maintaining cell identity: PRC2-mediated regulation of transcription and cancer.Dysregulation of histone methyltransferases in breast cancer - Opportunities for new targeted therapies?Cell lineage determinants as regulators of breast cancer metastasis.Epigenetics and Cancer Stem Cells: Unleashing, Hijacking, and Restricting Cellular Plasticity.Breast cancer stem cells as last soldiers eluding therapeutic burn: A hard nut to crack.The matricellular protein CCN6 (WISP3) decreases Notch1 and suppresses breast cancer initiating cells.Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation.Anti-cancer effects of curcumin on lung cancer through the inhibition of EZH2 and NOTCH1.

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EZH2 expands breast stem cells through activation of NOTCH1 signaling.

http://www.wikidata.org/entity/Q37612687

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 10 February 2014

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

EZH2 expands breast stem cells through activation of NOTCH1 signaling.

@en

EZH2 expands breast stem cells through activation of NOTCH1 signaling.

@nl

type

label

EZH2 expands breast stem cells through activation of NOTCH1 signaling.

@en

EZH2 expands breast stem cells through activation of NOTCH1 signaling.

@nl

prefLabel

EZH2 expands breast stem cells through activation of NOTCH1 signaling.

@en

EZH2 expands breast stem cells through activation of NOTCH1 signaling.

@nl

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PNAS.1308953111

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Proceedings of the National Academy of Sciences of the United States of America

P1476

EZH2 expands breast stem cells through activation of NOTCH1 signaling.

@en

P2093

Celina G Kleer

http://www.w3.org/2001/XMLSchema#string

Heather M Moore

http://www.w3.org/2001/XMLSchema#string

Kathy A Toy

http://www.w3.org/2001/XMLSchema#string

Maria E Gonzalez

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Michael S Sabel

http://www.w3.org/2001/XMLSchema#string

Wei Huang

http://www.w3.org/2001/XMLSchema#string

Xin Li

http://www.w3.org/2001/XMLSchema#string

P2860

Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells

An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB

ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome

EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

Prospective identification of tumorigenic breast cancer cells

Role of histone H3 lysine 27 methylation in Polycomb-group silencing

The role of EZH2 in tumour progression

Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease.

In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

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3098-3103

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10.1073/PNAS.1308953111

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260154634

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24516139

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3939892

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