Tumor Necrosis Factor-related apoptosis-inducing ligand (TRAIL) Receptor-1 and Receptor-2 agonists for cancer therapy.
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Caspase-8 activation by TRAIL monotherapy predicts responses to IAPi and TRAIL combination treatment in breast cancer cell linesStructural basis of LaDR5, a novel agonistic anti-death receptor 5 (DR5) monoclonal antibody, to inhibit DR5/TRAIL complex formationThe TRAIL of oncogenes to apoptosis.The transmembrane domains of TNF-related apoptosis-inducing ligand (TRAIL) receptors 1 and 2 co-regulate apoptotic signaling capacity.Recombinant human CD19L-sTRAIL effectively targets B cell precursor acute lymphoblastic leukemia.Regulating TRAIL receptor-induced cell death at the membrane : a deadly discussionTNF superfamily protein-protein interactions: feasibility of small- molecule modulationLow Dose Total Body Irradiation Combined With Recombinant CD19-Ligand × Soluble TRAIL Fusion Protein is Highly Effective Against Radiation-Resistant B-Precursor Acute Lymphoblastic Leukemia in MiceC-type lectin-like molecule-1 (CLL1)-targeted TRAIL augments the tumoricidal activity of granulocytes and potentiates therapeutic antibody-dependent cell-mediated cytotoxicityTRAIL: not just for tumors anymore?Clinical targeting of the TNF and TNFR superfamiliesTherapeutic development in targeting protein-protein interactions with synthetic topological mimetics.Immunomodulation using agonists and antagonists: potential clinical applications.Targeting of the tumor necrosis factor receptor superfamily for cancer immunotherapy.Signals and Receptors.ONC201 induces cell death in pediatric non-Hodgkin's lymphoma cells.Programmed Death Ligand 1 (PD-L1)-targeted TRAIL combines PD-L1-mediated checkpoint inhibition with TRAIL-mediated apoptosis induction.RIP1 protein-dependent assembly of a cytosolic cell death complex is required for inhibitor of apoptosis (IAP) inhibitor-mediated sensitization to lexatumumab-induced apoptosis.TRAIL receptor deficiency sensitizes mice to dextran sodium sulphate-induced colitis and colitis-associated carcinogenesis.Safety, pharmacokinetics, and pharmacodynamics of the DR5 antibody LBY135 alone and in combination with capecitabine in patients with advanced solid tumors.A CD47-blocking TRAIL fusion protein with dual pro-phagocytic and pro-apoptotic anticancer activity.
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P2860
Tumor Necrosis Factor-related apoptosis-inducing ligand (TRAIL) Receptor-1 and Receptor-2 agonists for cancer therapy.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on January 2010
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Tumor Necrosis Factor-related ...... 2 agonists for cancer therapy.
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type
label
Tumor Necrosis Factor-related ...... 2 agonists for cancer therapy.
@en
prefLabel
Tumor Necrosis Factor-related ...... 2 agonists for cancer therapy.
@en
P2093
P2860
P1476
Tumor Necrosis Factor-related ...... 2 agonists for cancer therapy.
@en
P2093
Gilles Gallant
Jerry Klein
Norma Lynn Fox
Robin Humphreys
Troy A Luster
P2860
P356
10.1517/14712590903319656
P407
P577
2010-01-01T00:00:00Z