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Functional roles of Syk in macrophage-mediated inflammatory responsesA respiratory chain controlled signal transduction cascade in the mitochondrial intermembrane space mediates hydrogen peroxide signalingThe Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclustersFcRL4 acts as an adaptive to innate molecular switch dampening BCR signaling and enhancing TLR signaling.Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid LeukemiaTyrosines in the carboxyl terminus regulate Syk kinase activity and functionProgress towards the development of SH2 domain inhibitors.PKIS: computational identification of protein kinases for experimentally discovered protein phosphorylation sitesRegulation and function of syk tyrosine kinase in mast cell signaling and beyond.Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemiaSignaling by myeloid C-type lectin receptors in immunity and homeostasisOnce phosphorylated, tyrosines in carboxyl terminus of protein-tyrosine kinase Syk interact with signaling proteins, including TULA-2, a negative regulator of mast cell degranulationCombined loss of the BH3-only proteins Bim and Bmf restores B-cell development and function in TACI-Ig transgenic miceThe SYK tyrosine kinase: a crucial player in diverse biological functions.Identifying Yersinia YopH-targeted signal transduction pathways that impair neutrophil responses during in vivo murine infectionIntracellular Signaling Pathways in Rheumatoid ArthritisThe dissociation activation model of B cell antigen receptor triggering.TEC family kinases in health and disease--loss-of-function of BTK and ITK and the gain-of-function fusions ITK-SYK and BTK-SYK.3-aminopyrazolopyrazine derivatives as spleen tyrosine kinase inhibitors.Depletion of STAT5 blocks TEL-SYK-induced APMF-type leukemia with myelofibrosis and myelodysplasia in mice.Phosphorylation of the activation loop tyrosine 823 in c-Kit is crucial for cell survival and proliferation.Inhibition of spleen tyrosine kinase activation ameliorates inflammation, cell death, and steatosis in alcoholic liver disease.Differential Requirements for Src-Family Kinases in SYK or ZAP70-Mediated SLP-76 Phosphorylation in Lymphocytes.Signaling of the ITK (interleukin 2-inducible T cell kinase)-SYK (spleen tyrosine kinase) fusion kinase is dependent on adapter SLP-76 and on the adapter function of the kinases SYK and ZAP70.The Phospholipase Cγ2 Mutants R665W and L845F Identified in Ibrutinib-resistant Chronic Lymphocytic Leukemia Patients Are Hypersensitive to the Rho GTPase Rac2 Protein.Increased frequency of a unique spleen tyrosine kinase bright memory B cell population in systemic lupus erythematosus.Over expression of proteins that alter the intracellular signaling pathways in the cytoplasm of the liver cells forming Mallory-Denk bodies.A hypomorphic IgH-chain allele affects development of B-cell subsets and favours receptor editing.Unperturbed Immune Function despite Mutation of C-Terminal Tyrosines in Syk Previously Implicated in Signaling and Activity Regulation.B-cell subsets, signaling and their roles in secretion of autoantibodies.Increased Syk phosphorylation leads to overexpression of TRAF6 in peripheral B cells of patients with systemic lupus erythematosus.Suboptimal B-cell antigen receptor signaling activity in vivo elicits germinal center counterselection mechanisms.Role of the Spleen Tyrosine Kinase Pathway in Driving Inflammation in IgA Nephropathy
P2860
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P2860
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Autoinhibition and adapter function of Syk.
@en
Autoinhibition and adapter function of Syk.
@nl
type
label
Autoinhibition and adapter function of Syk.
@en
Autoinhibition and adapter function of Syk.
@nl
prefLabel
Autoinhibition and adapter function of Syk.
@en
Autoinhibition and adapter function of Syk.
@nl
P2860
P1476
Autoinhibition and adapter function of Syk
@en
P2093
Gesina Grothe
Michael Reth
P2860
P304
P356
10.1111/J.1600-065X.2009.00837.X
P577
2009-11-01T00:00:00Z