Dissecting the role of mTOR: lessons from mTOR inhibitors.
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Tuberous sclerosis-2 (TSC2) regulates the stability of death-associated protein kinase-1 (DAPK) through a lysosome-dependent degradation pathwayA phase II trial of the oral mTOR inhibitor everolimus in relapsed aggressive lymphomaPI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastomaPI3K/Akt/mTOR inhibitors in breast cancerAltered metabolism and persistent starvation behaviors caused by reduced AMPK function in DrosophilamTOR-independent 4E-BP1 phosphorylation is associated with cancer resistance to mTOR kinase inhibitors.The Role and Application of Sirtuins and mTOR Signaling in the Control of Ovarian FunctionsmTOR activation is a biomarker and a central pathway to autoimmune disorders, cancer, obesity, and agingImatinib reverses doxorubicin resistance by affecting activation of STAT3-dependent NF-κB and HSP27/p38/AKT pathways and by inhibiting ABCB1Activation of mammalian target of rapamycin contributes to pain nociception induced in rats by BmK I, a sodium channel-specific modulatorForced expression of the DEK-NUP214 fusion protein promotes proliferation dependent on upregulation of mTORThree distinct ribosome assemblies modulated by translation are the building blocks of polysomes.ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change.The pros and the cons of mTOR inhibitors in kidney transplantation.Long-term results of the phase II trial of the oral mTOR inhibitor everolimus (RAD001) in relapsed or refractory Waldenstrom Macroglobulinemia.TAK-228 (formerly MLN0128), an investigational oral dual TORC1/2 inhibitor: A phase I dose escalation study in patients with relapsed or refractory multiple myeloma, non-Hodgkin lymphoma, or Waldenström's macroglobulinemia.Bicaudal C mutation causes myc and TOR pathway up-regulation and polycystic kidney disease-like phenotypes in Drosophila.Amino Acid (Leucine) Chromatography: A Study of Branched-Chain Aminoaciduria in Type 2 Diabetes.Systemic meta-analysis assessing the short term applicability of early conversion to mammalian target of rapamycin inhibitors in kidney transplant.Cytokines that promote nerve regeneration.The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.The PI3K/AKT/mTOR pathway in breast cancer: targets, trials and biomarkers.The mTOR kinase inhibitor Everolimus decreases S6 kinase phosphorylation but fails to reduce mutant huntingtin levels in brain and is not neuroprotective in the R6/2 mouse model of Huntington's disease.Growth hormone pathways signaling for cell proliferation and survival in hippocampal neural precursors from postnatal mice.Ligands for FKBP12 increase Ca2+ influx and protein synthesis to improve skeletal muscle function.Expression of a novel stress-inducible protein, sestrin 2, in rat glomerular parietal epithelial cells.The Role of PI3K/Akt/mTOR Signaling in Gastric Carcinoma.Role for mammalian target of rapamycin complex 1 signaling in neuroadaptations underlying alcohol-related disordersLipidomic assessment of plasma and placenta of women with early-onset preeclampsia.The Long-HER study: clinical and molecular analysis of patients with HER2+ advanced breast cancer who become long-term survivors with trastuzumab-based therapy.Metabolic induction and early responses of mouse blastocyst developmental programming following maternal low protein diet affecting life-long health.Evaluation of the impact of the cancer therapy everolimus on the central nervous system in miceTranslational control of cyclins.Pig immune response to general stimulus and to porcine reproductive and respiratory syndrome virus infection: a meta-analysis approach.Response to mTOR inhibition: activity of eIF4E predicts sensitivity in cell lines and acquired changes in eIF4E regulation in breast cancer.Role of mTOR, Bad, and Survivin in RasGAP Fragment N-Mediated Cell ProtectionRapamycin treatment improves neuron viability in an in vitro model of stroke.RSK activation of translation factor eIF4B drives abnormal increases of laminin γ2 and MYC protein during neoplastic progression to squamous cell carcinoma.Characterization of the altered gene expression profile in early porcine embryos generated from parthenogenesis and somatic cell chromatin transfer.Resistance to the translation initiation inhibitor silvestrol is mediated by ABCB1/P-glycoprotein overexpression in acute lymphoblastic leukemia cells.
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Dissecting the role of mTOR: lessons from mTOR inhibitors.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 11 December 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Dissecting the role of mTOR: lessons from mTOR inhibitors.
@en
Dissecting the role of mTOR: lessons from mTOR inhibitors.
@nl
type
label
Dissecting the role of mTOR: lessons from mTOR inhibitors.
@en
Dissecting the role of mTOR: lessons from mTOR inhibitors.
@nl
prefLabel
Dissecting the role of mTOR: lessons from mTOR inhibitors.
@en
Dissecting the role of mTOR: lessons from mTOR inhibitors.
@nl
P1476
Dissecting the role of mTOR: lessons from mTOR inhibitors.
@en
P2093
Bruno D Fonseca
Ryan J O Dowling
P304
P356
10.1016/J.BBAPAP.2009.12.001
P407
P577
2009-12-11T00:00:00Z