Role of Raf-1 serine/threonine protein kinase in growth factor signal transduction.
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Regulation of Raf-1 kinase activity by the 14-3-3 family of proteins14-3-3 is not essential for Raf-1 function: identification of Raf-1 proteins that are biologically activated in a 14-3-3- and Ras-independent mannerRaf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulationActivation of phosphoinositide 3-kinase by interaction with Ras and by point mutationIdentification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew3pK, a novel mitogen-activated protein (MAP) kinase-activated protein kinase, is targeted by three MAP kinase pathways3pK, a new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene regionConditionally oncogenic forms of the A-Raf and B-Raf protein kinases display different biological and biochemical properties in NIH 3T3 cellsInhibition of platelet-derived growth factor- and epidermal growth factor-mediated mitogenesis and signaling in 3T3 cells expressing delta Raf-1:ER, an estradiol-regulated form of Raf-1.Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase.A single amino acid change in Raf-1 inhibits Ras binding and alters Raf-1 functionPlasma membrane-targeted Raf kinase activates NF-kappaB and human immunodeficiency virus type 1 replication in T lymphocytesBoth the polycythemia- and anemia-inducing strains of Friend spleen focus-forming virus induce constitutive activation of the Raf-1/mitogen-activated protein kinase signal transduction pathwayComplex formation between RAS and RAF and other protein kinasesDirect interaction and N-terminal phosphorylation of c-Jun by c-Mil/Raf.Transcriptional regulation of the Drosophila-raf proto-oncogene by the DNA replication-related element (DRE)/DRE-binding factor (DREF) system.Oncogene activation of HIV-LTR-driven expression via the NF-kappa B binding sitesEnzymatic characteristics of the c-Raf-1 protein kinaseE2F-dependent transcription of the raf proto-oncogene during Drosophila development.Polyomavirus middle-sized tumor antigen modulates c-Jun phosphorylation and transcriptional activity.Raf-1 kinase targets GA-binding protein in transcriptional regulation of the human immunodeficiency virus type 1 promoter.Activation of the MAP kinase pathway by FGF-1 correlates with cell proliferation induction while activation of the Src pathway correlates with migration.The cytoplasmic raf oncogene induces a neuronal phenotype in PC12 cells: a potential role for cellular raf kinases in neuronal growth factor signal transductionTransactivation by hepatitis B virus X protein is promiscuous and dependent on mitogen-activated cellular serine/threonine kinases.Components of the nuclear signaling cascade that regulate collagenase gene expression in response to integrin-derived signals.GTP-dependent association of Raf-1 with Ha-Ras: identification of Raf as a target downstream of Ras in mammalian cells.RelA is a potent transcriptional activator of the CD28 response element within the interleukin 2 promoter.Regulation of Raf-1-dependent signaling during early Xenopus development.Induction of cell proliferation in quiescent NIH 3T3 cells by oncogenic c-Raf-1.Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1.Raf-1 protein kinase activates the NF-kappa B transcription factor by dissociating the cytoplasmic NF-kappa B-I kappa B complex.Depletion of protein kinase C (PKC) by 12-O-tetradecanoylphorbol-13-acetate (TPA) enhances platinum drug sensitivity in human ovarian carcinoma cells.Biochemical analysis of torso and D-raf during Drosophila embryogenesis: implications for terminal signal transductionRaf-1 protein kinase is important for progesterone-induced Xenopus oocyte maturation and acts downstream of mosOncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73.Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase.The Ras-Raf pathway is activated in human immunodeficiency virus-infected monocytes and particpates in the activation of NF-kappa B.Potential molecular mechanisms of oxidant-induced carcinogenesis.UV-induced activation of AP-1 involves obligatory extranuclear steps including Raf-1 kinaseIL-4 activates a distinct signal transduction cascade from IL-3 in factor-dependent myeloid cells.
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Role of Raf-1 serine/threonine protein kinase in growth factor signal transduction.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on April 1991
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Role of Raf-1 serine/threonine protein kinase in growth factor signal transduction.
@en
Role of Raf-1 serine/threonine protein kinase in growth factor signal transduction.
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type
label
Role of Raf-1 serine/threonine protein kinase in growth factor signal transduction.
@en
Role of Raf-1 serine/threonine protein kinase in growth factor signal transduction.
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prefLabel
Role of Raf-1 serine/threonine protein kinase in growth factor signal transduction.
@en
Role of Raf-1 serine/threonine protein kinase in growth factor signal transduction.
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P1433
P1476
Role of Raf-1 serine/threonine protein kinase in growth factor signal transduction
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P2093
P304
P407
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1991-04-01T00:00:00Z