Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication.
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Functions of Ubiquitin and SUMO in DNA Replication and Replication StressArabidopsis DNA polymerase ϵ recruits components of Polycomb repressor complex to mediate epigenetic gene silencing.Epigenetic mechanisms drive the progression of neurofibromas to malignant peripheral nerve sheath tumorsCancer Cells Hijack PRC2 to Modify Multiple Cytokine PathwaysModeling epigenetic regulation of PRC1 protein accumulation in the cell cycle.Chromobox homolog 2 protein: A novel biomarker for predicting prognosis and Taxol sensitivity in patients with breast cancer.CBX7 is a glioma prognostic marker and induces G1/S arrest via the silencing of CCNE1.Global gene expression in granulosa cells of growing, plateau and atretic dominant follicles in cattleTop2a identifies and provides epigenetic rationale for novel combination therapeutic strategies for aggressive prostate cancer.Bmi-1: At the crossroads of physiological and pathological biology.miR-200c/Bmi1 axis and epithelial-mesenchymal transition contribute to acquired resistance to BRAF inhibitor treatment.A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence.Polycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation network.Cbx7 is epigenetically silenced in glioblastoma and inhibits cell migration by targeting YAP/TAZ-dependent transcription.The long non-coding RNA EPB41L4A-AS2 inhibits tumor proliferation and is associated with favorable prognoses in breast cancer and other solid tumors.Epigenetics of hematopoiesis and hematological malignancies.The controversial role of the Polycomb group proteins in transcription and cancer: how much do we not understand Polycomb proteins?Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas.Epigenetic balance of gene expression by Polycomb and COMPASS families.On-site remodeling at chromatin: How multiprotein complexes are rebuilt during DNA repair and transcriptional activation.Concise Review: Geminin-A Tale of Two Tails: DNA Replication and Transcriptional/Epigenetic Regulation in Stem Cells.PRC2 preserves intestinal progenitors and restricts secretory lineage commitment.Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal.The chromatin environment shapes DNA replication origin organization and defines origin classes.The cohesin complex prevents Myc-induced replication stress.Maintenance of leukemic cell identity by the activity of the Polycomb complex PRC1 in mice.Polycomb Repressor Complex 2 in Genomic Instability and CancerCoordinate redeployment of PRC1 proteins suppresses tumor formation during Drosophila development.Determination of synthetic lethal interactions to provide therapeutic direction to end aggressive prostate cancer.EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation.The Antisense Transcript SMN-AS1 Regulates SMN Expression and Is a Novel Therapeutic Target for Spinal Muscular Atrophy.PREP1 tumor suppressor protects the late-replicating DNA by controlling its replication timing and symmetry.Regulation of Cellular Senescence by Polycomb Chromatin Modifiers through Distinct DNA Damage- and Histone Methylation-Dependent Pathways.EZH2 promotes DNA replication by stabilizing interaction of POLδ and PCNA via methylation-mediated PCNA trimerization
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Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 14 April 2014
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Polycomb proteins control prol ...... by regulating DNA replication.
@en
Polycomb proteins control prol ...... by regulating DNA replication.
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type
label
Polycomb proteins control prol ...... by regulating DNA replication.
@en
Polycomb proteins control prol ...... by regulating DNA replication.
@nl
prefLabel
Polycomb proteins control prol ...... by regulating DNA replication.
@en
Polycomb proteins control prol ...... by regulating DNA replication.
@nl
P2093
P2860
P50
P356
P1476
Polycomb proteins control prol ...... by regulating DNA replication.
@en
P2093
Andrea Piunti
Andrea Scelfo
Aurora Cerutti
Giulia Fragola
Laura Cedrone
Linda Olsson
Sriganesh Jammula
Stefano Casola
P2860
P2888
P356
10.1038/NCOMMS4649
P407
P50
P577
2014-04-14T00:00:00Z
P5875
P6179
1016529920