Bisphosphonates: molecular mechanisms of action and effects on bone cells, monocytes and macrophages.
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Bisphosphonates as anticancer agents in early breast cancer: preclinical and clinical evidenceDesign, Synthesis, Calorimetry, and Crystallographic Analysis of 2-Alkylaminoethyl-1,1-bisphosphonates as Inhibitors of Trypanosoma cruzi Farnesyl Diphosphate SynthaseEffect of bisphosphonate use in patients with symptomatic and radiographic knee osteoarthritis: data from the Osteoarthritis Initiative.Genetic ablation of CD68 results in mice with increased bone and dysfunctional osteoclasts.Modifying the osteoblastic niche with zoledronic acid in vivo-potential implications for breast cancer bone metastasisBisphosphonate therapy and osteonecrosis of the jaw complicated with a temporal abscess in an elderly woman with rheumatoid arthritis: a case report.Real-time intravital imaging establishes tumor-associated macrophages as the extraskeletal target of bisphosphonate action in cancerAddressing the controversy: do bisphosphonates directly affect primary tumors?Role of IL-1 receptor-associated kinase-M (IRAK-M) in priming of immune and inflammatory responses by nitrogen bisphosphonates.Long-term Treatment with Oriental Medicinal Herb Artemisia princeps Alters Neuroplasticity in a Rat Model of Ovarian Hormone Deficiency.Isoprenoids and related pharmacological interventions: potential application in Alzheimer's disease.2-alkylaminoethyl-1,1-bisphosphonic acids are potent inhibitors of the enzymatic activity of Trypanosoma cruzi squalene synthase.Effects of combined alendronate and alfacalcidol on prevention of fractures in osteoporosis patients: a network meta-analysis.1-(Fluoroalkylidene)-1,1-bisphosphonic acids are potent and selective inhibitors of the enzymatic activity of Toxoplasma gondii farnesyl pyrophosphate synthaseThe impact of menopause on bone, zoledronic acid, and implications for breast cancer growth and metastasis.Design, synthesis and biological evaluation of sulfur-containing 1,1-bisphosphonic acids as antiparasitic agents.Variations in nanomechanical properties and tissue composition within trabeculae from an ovine model of osteoporosis and treatment.A highly sensitive prenylation assay reveals in vivo effects of bisphosphonate drug on the Rab prenylome of macrophages outside the skeleton.CLEC5A is critical for dengue virus-induced osteoclast activation and bone homeostasis.Basic research and clinical applications of bisphosphonates in bone disease: what have we learned over the last 40 years?New insights into molecular recognition of 1,1-bisphosphonic acids by farnesyl diphosphate synthase.Bone metastasis in prostate cancer: emerging therapeutic strategies.Farnesyl pyrophosphate synthase modulators: a patent review (2006 - 2010).New antibacterials for the treatment of toxoplasmosis; a patent review.Progress in the treatment of bone metastases in cancer patients.Fracture mortality: associations with epidemiology and osteoporosis treatment.Effect of clodronate treatment on risk of fracture: a systematic review and meta-analysis.Biology and Treatment of Paget's Disease of Bone.Approaches for Designing new Potent Inhibitors of Farnesyl Pyrophosphate Synthase.Detection and treatment of Trypanosoma cruzi: a patent review (2011-2015).Macrophages and skeletal health.Bisphosphonate-Functionalized Imaging Agents, Anti-Tumor Agents and Nanocarriers for Treatment of Bone Cancer.Development of nanomaterials for bone-targeted drug delivery.Location matters: osteoblast and osteoclast distribution is modified by the presence and proximity to breast cancer cells in vivo.Bisphosphonates and bone diseases: past, present and future.Bone-seeking TRAP conjugates: surprising observations and their implications on the development of gallium-68-labeled bisphosphonates.Cutting edge: nitrogen bisphosphonate-induced inflammation is dependent upon mast cells and IL-1.Bisphosphonates for osteoarthritis.Care of cancer patients with liver and bone metastases - the place of pharmaceutical care in a balanced plan, focused on the patient's needs and goals.Isoprenoids and protein prenylation: implications in the pathogenesis and therapeutic intervention of Alzheimer's disease.
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Bisphosphonates: molecular mechanisms of action and effects on bone cells, monocytes and macrophages.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Bisphosphonates: molecular mec ...... ls, monocytes and macrophages.
@en
Bisphosphonates: molecular mec ...... ls, monocytes and macrophages.
@nl
type
label
Bisphosphonates: molecular mec ...... ls, monocytes and macrophages.
@en
Bisphosphonates: molecular mec ...... ls, monocytes and macrophages.
@nl
prefLabel
Bisphosphonates: molecular mec ...... ls, monocytes and macrophages.
@en
Bisphosphonates: molecular mec ...... ls, monocytes and macrophages.
@nl
P2093
P1476
Bisphosphonates: molecular mec ...... lls, monocytes and macrophages
@en
P2093
A J Roelofs
F H Ebetino
P304
P356
10.2174/138161210793563635
P577
2010-01-01T00:00:00Z