about
The rat GPRC6A: cloning and characterizationα4βδ GABA(A) receptors are high-affinity targets for γ-hydroxybutyric acid (GHB)Novel cyclic gamma-hydroxybutyrate (GHB) analogs with high affinity and stereoselectivity of binding to GHB sites in rat brain.Identification of the First Highly Subtype-Selective Inhibitor of Human GABA Transporter GAT3.Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors.Novel high-affinity and selective biaromatic 4-substituted gamma-hydroxybutyric acid (GHB) analogues as GHB ligands: design, synthesis, and binding studies.Pharmacological characterisation of murine α4β1δ GABAA receptors expressed in Xenopus oocytes.Positive allosteric modulation of the GHB high-affinity binding site by the GABAA receptor modulator monastrol and the flavonoid catechin.Known regulators of nitric oxide synthase and arginase are agonists at the human G-protein-coupled receptor GPRC6A.New synthesis and tritium labeling of a selective ligand for studying high-affinity γ-hydroxybutyrate (GHB) binding sites.Molecular pharmacology of promiscuous seven transmembrane receptors sensing organic nutrients.The emerging role of promiscuous 7TM receptors as chemosensors for food intake.Potency of GABA at human recombinant GABA(A) receptors expressed in Xenopus oocytes: a mini review.Promiscuous seven transmembrane receptors sensing L-α-amino acids.The GPCR, class C, group 6, subtype A (GPRC6A) receptor: from cloning to physiological function.GHB receptor targets in the CNS: focus on high-affinity binding sites.Development of a Robust Mammalian Cell-based Assay for Studying Recombinant α4 β1/3 δ GABAA Receptor Subtypes.Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Control Cell Surface Expression and Function.In Vitro and In Vivo Evidence for Active Brain Uptake of the GHB Analog HOCPCA by the Monocarboxylate Transporter Subtype 1.Delineation of the GPRC6A receptor signaling pathways using a mammalian cell line stably expressing the receptor.Autoradiographic imaging and quantification of the high-affinity GHB binding sites in rodent brain using (3)H-HOCPCA.Chemogenomic discovery of allosteric antagonists at the GPRC6A receptor.Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and pharmacological characterization of gamma-aminobutyric acid (GABA) related compounds.Activity of L-alpha-amino acids at the promiscuous goldfish odorant receptor 5.24.Identification of Histamine H3 Receptor Ligands Using a New Crystal Structure Fragment-based Method.Design, synthesis, and in vitro pharmacology of new radiolabeled gamma-hydroxybutyric acid analogues including photolabile analogues with irreversible binding to the high-affinity gamma-hydroxybutyric acid binding sites.Novel radioiodinated {gamma}-hydroxybutyric acid analogues for radiolabeling and Photolinking of high-affinity {gamma}-hydroxybutyric acid binding sites.Selective mGAT2 (BGT-1) GABA uptake inhibitors: design, synthesis, and pharmacological characterization.The L-α-amino acid receptor GPRC6A is expressed in the islets of Langerhans but is not involved in L-arginine-induced insulin release.Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT(2A)/5-HT(2C) receptor agonists with pro-cognitive properties.A sequential high-yielding large-scale solution-method for synthesis of philanthotoxin analogues.Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA(B)(1)-deficient mice.Cyanohydrin glycosides of Passiflora: distribution pattern, a saturated cyclopentane derivative from P. guatemalensis, and formation of pseudocyanogenic alpha-hydroxyamides as isolation artefacts.Phenylacetic acids and the structurally related non-steroidal anti-inflammatory drug diclofenac bind to specific gamma-hydroxybutyric acid sites in rat brain.Astrocytic GABA Transporters: Pharmacological Properties and Targets for Antiepileptic Drugs.GAT3 selective substrate l-isoserine upregulates GAT3 expression and increases functional recovery after a focal ischemic stroke in mice.Pharmacological Characterization of [3H]ATPCA as a Substrate for Studying the Functional Role of the Betaine/GABA Transporter 1 and the Creatine Transporter.Structure-Activity Relationship, Pharmacological Characterization, and Molecular Modeling of Noncompetitive Inhibitors of the Betaine/γ-Aminobutyric Acid Transporter 1 (BGT1).Molecular Hybridization of Potent and Selective γ-Hydroxybutyric Acid (GHB) Ligands: Design, Synthesis, Binding Studies, and Molecular Modeling of Novel 3-Hydroxycyclopent-1-enecarboxylic Acid (HOCPCA) and trans-γ-Hydroxycrotonic Acid (T-HCA) AnalogGlial GABA Transporters as Modulators of Inhibitory Signalling in Epilepsy and Stroke.
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description
hulumtuese
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researcher
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wetenschapper
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հետազոտող
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name
Petrine Wellendorph
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Petrine Wellendorph
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Petrine Wellendorph
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Petrine Wellendorph
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Petrine Wellendorph
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type
label
Petrine Wellendorph
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Petrine Wellendorph
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Petrine Wellendorph
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Petrine Wellendorph
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Petrine Wellendorph
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prefLabel
Petrine Wellendorph
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Petrine Wellendorph
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Petrine Wellendorph
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Petrine Wellendorph
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Petrine Wellendorph
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P108
P1053
H-8328-2015
P106
P108
P1153
6507534999
P21
P31
P3829
P496
0000-0002-5455-8013