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Aging and cancer: can mTOR inhibitors kill two birds with one drug?

Aging and cancer: can mTOR inhibitors kill two birds with one drug?

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Epigenetic regulation of caloric restriction in aging Live strong and prosper: the importance of skeletal muscle strength for healthy ageing Rapamycin increases mitochondrial efficiency by mtDNA-dependent reprogramming of mitochondrial metabolism in Drosophila.A cytoprotective perspective on longevity regulation Combined treatment of rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver.Polyamines in aging and disease The combinatorial activation of the PI3K and Ras/MAPK pathways is sufficient for aggressive tumor formation, while individual pathway activation supports cell persistence.Rapamycin extends life span of Rb1+/- mice by inhibiting neuroendocrine tumors Should diabetic women with breast cancer have their own intervention studies?mTOR Inhibition: From Aging to Autism and Beyond.Homeostasis and the importance for a balance between AKT/mTOR activity and intracellular signaling.Aberrant mTOR activation in senescence and aging: A mitochondrial stress response?

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Aging and cancer: can mTOR inhibitors kill two birds with one drug?

http://www.wikidata.org/entity/Q37851872

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 11 March 2011

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Aging and cancer: can mTOR inhibitors kill two birds with one drug?

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Aging and cancer: can mTOR inhibitors kill two birds with one drug?

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Aging and cancer: can mTOR inhibitors kill two birds with one drug?

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Aging and cancer: can mTOR inhibitors kill two birds with one drug?

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Aging and cancer: can mTOR inhibitors kill two birds with one drug?

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Aging and cancer: can mTOR inhibitors kill two birds with one drug?

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S11523-011-0168-7

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Targeted oncology

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Aging and cancer: can mTOR inhibitors kill two birds with one drug?

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Arlan Richardson

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Zelton Dave Sharp

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Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

Metformin in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug?

C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span

Extension of chronological life span in yeast by decreased TOR pathway signaling

The TOR pathway comes of age

Extending healthy life span--from yeast to humans

Lessons on longevity from budding yeast

mTOR: from growth signal integration to cancer, diabetes and ageing

Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments.

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

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s11523-011-0168-7

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41-51

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scholarly article

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10.1007/S11523-011-0168-7

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1

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2011-03-11T00:00:00Z

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21394528

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