Drug metabolite profiling and identification by high-resolution mass spectrometry. - Wikidata - wikimedia - TriplyDB

Drug metabolite profiling and identification by high-resolution mass spectrometry.

Drug metabolite profiling and identification by high-resolution mass spectrometry.

http://www.wikidata.org/entity/Q37883742

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MassCascade: Visual Programming for LC-MS Data Processing in Metabolomics Trends in the application of high-resolution mass spectrometry for human biomonitoring: An analytical primer to studying the environmental chemical space of the human exposome Exploring the utility of high-resolution MS with post-acquisition data mining for simultaneous exogenous and endogenous metabolite profiling.Data acquisition and data mining techniques for metabolite identification using LC coupled to high-resolution MS.Identification of urinary metabolites of imperatorin with a single run on an LC/Triple TOF system based on multiple mass defect filter data acquisition and multiple data mining techniques.Post-acquisition data processing for the screening of transformation products of different organic contaminants. Two-year monitoring of river water using LC-ESI-QTOF-MS and GCxGC-EI-TOF-MS.An accelerated background subtraction algorithm for processing high-resolution MS data and its application to metabolite identification.Exposure Marker Discovery of Phthalates Using Mass Spectrometry.Absorption, distribution, metabolism, and excretion of [14C]-dasotraline in humans.Qualitative-(semi)quantitative data acquisition of artemisinin and its metabolites in rat plasma using an LTQ/Orbitrap mass spectrometer.Simultaneous screening of glutathione and cyanide adducts using precursor ion and neutral loss scans-dependent product ion spectral acquisition and data mining tools.Integrated quantitative and qualitative workflow for in vivo bioanalytical support in drug discovery using hybrid Q-TOF-MS.Metabolic profiling of new synthetic cannabinoids AMB and 5F-AMB by human hepatocyte and liver microsome incubations and high-resolution mass spectrometry.Technologies and strategies to characterize and quantitate metabolites in drug discovery and development.The development and assessment of high-throughput mass spectrometry-based methods for the quantification of a nanoparticle drug delivery agent in cellular lysate.Systems medicine: evolution of systems biology from bench to bedside An Integrated Approach for Studying Exposure, Metabolism, and Disposition of Multiple Component Herbal Medicines Using High-Resolution Mass Spectrometry and Multiple Data Processing Tools.LC-high-resolution-MS/MS analysis of chemical compounds in rat plasma after oral administration of Nao-Mai-Tong and its individual herbs.Electrospray Quadrupole Travelling Wave Ion Mobility Time-of-Flight Mass Spectrometry for the Detection of Plasma Metabolome Changes Caused by Xanthohumol in Obese Zucker (fa/fa) Rats.Bioanalytical aspects of clinical mass balance studies in oncology.Current applications of high-resolution mass spectrometry in drug metabolism studies.Recent advances in metabolite identification and quantitative bioanalysis by LC-Q-TOF MS.Radiolabeled mass-balance excretion and metabolism studies in laboratory animals: a commentary on why they are still necessary.Biotransformation and biocatalysis: roles and applications in the discovery of antimalarials.An introduction to hybrid ion trap/time-of-flight mass spectrometry coupled with liquid chromatography applied to drug metabolism studies.Metabolite structure analysis by high-resolution MS: supporting drug-development studies.Network pharmacology strategies toward multi-target anticancer therapies: from computational models to experimental design principles.Software automation tools for increased throughput metabolic soft-spot identification in early drug discovery.Reflecting on a decade of metabolite screening and monitoring.Applications of mass spectrometry in drug metabolism: 50 years of progress.Post-acquisition data mining techniques for LC-MS/MS-acquired data in drug metabolite identification.Introduction: use of radioactive compounds in drug discovery and development.Site of Metabolism Prediction Based on ab initio Derived Atom Representations.An efficient liquid chromatography-high resolution mass spectrometry approach for the optimization of the metabolic stability of therapeutic peptides.Mass spectrometry-based proteomics in molecular diagnostics: discovery of cancer biomarkers using tissue culture.In vivo drug metabolite identification in preclinical ADME studies by means of UPLC/TWIMS/high resolution-QTOF MS(E) and control comparison: cost and benefit of vehicle-dosed control samples.Systematic and comprehensive strategy for metabolite profiling in bioanalysis using software-assisted HPLC-Q-TOF: magnoflorine as an example.One drop chemical derivatization--DESI-MS analysis for metabolite structure identification.Elucidation of the Biotransformation Pathways of a Galnac3-conjugated Antisense Oligonucleotide in Rats and Monkeys.Fragmentation of diamide derivatives of 3,4-ethylenedioxythiophene.

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Drug metabolite profiling and identification by high-resolution mass spectrometry.

http://www.wikidata.org/entity/Q37883742

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on June 2011

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Drug metabolite profiling and identification by high-resolution mass spectrometry.

@en

Drug metabolite profiling and identification by high-resolution mass spectrometry.

@nl

type

label

Drug metabolite profiling and identification by high-resolution mass spectrometry.

@en

Drug metabolite profiling and identification by high-resolution mass spectrometry.

@nl

prefLabel

Drug metabolite profiling and identification by high-resolution mass spectrometry.

@en

Drug metabolite profiling and identification by high-resolution mass spectrometry.

@nl

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JBC.R110.200055

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Journal of Biological Chemistry

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Drug metabolite profiling and identification by high-resolution mass spectrometry

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Mingshe Zhu

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W Griffith Humphreys

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P2860

Integration of knowledge-based metabolic predictions with liquid chromatography data-dependent tandem mass spectrometry for drug metabolism studies: application to studies on the biotransformation of indinavir.

Accelerated throughput metabolic route screening in early drug discovery using high-resolution liquid chromatography/quadrupole time-of-flight mass spectrometry and automated data analysis.

Application of a linear ion trap/orbitrap mass spectrometer in metabolite characterization studies: examination of the human liver microsomal metabolism of the non-tricyclic anti-depressant nefazodone using data-dependent accurate mass measurements.

Detection and characterization of metabolites in biological matrices using mass defect filtering of liquid chromatography/high resolution mass spectrometry data.

Metabolite identification by data-dependent accurate mass spectrometric analysis at resolving power of 60,000 in external calibration mode using an LTQ/Orbitrap.

An integrated method for metabolite detection and identification using a linear ion trap/Orbitrap mass spectrometer and multiple data processing techniques: application to indinavir metabolite detection.

An algorithm for thorough background subtraction from high-resolution LC/MS data: application for detection of glutathione-trapped reactive metabolites.

A generic method to detect electrophilic intermediates using isotopic pattern triggered data-dependent high-resolution accurate mass spectrometry.

Rapid screening of glutathione-trapped reactive metabolites by linear ion trap mass spectrometry with isotope pattern-dependent scanning and postacquisition data mining.

Application of mass spectrometry for metabolite identification.

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25419-25425

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scholarly article

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10.1074/JBC.R110.200055

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29

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286

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3138308

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