Accelerated throughput metabolic route screening in early drug discovery using high-resolution liquid chromatography/quadrupole time-of-flight mass spectrometry and automated data analysis.
about
Advances in structure elucidation of small molecules using mass spectrometryAnalytical tools and approaches for metabolite identification in early drug discovery.Post-acquisition data processing for the screening of transformation products of different organic contaminants. Two-year monitoring of river water using LC-ESI-QTOF-MS and GCxGC-EI-TOF-MS.Ultra-performance liquid chromatography coupled to time-of-flight mass spectrometry for robust, high-throughput quantitative analysis of an automated metabolic stability assay, with simultaneous determination of metabolic data.A comprehensive investigation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) metabolism in the mouse using a multivariate data analysis approach.High-performance liquid chromatography-tandem mass spectrometry in the identification and determination of phase I and phase II drug metabolites.Xenobiotic metabolism: a view through the metabolometer.High-resolution chromatography/time-of-flight MSE with in silico data mining is an information-rich approach to reactive metabolite screening.Current use of high-resolution mass spectrometry in drug screening relevant to clinical and forensic toxicology and doping control.Is nontarget screening of emerging contaminants by LC-HRMS successful? A plea for compound libraries and computer tools.Identification of xenobiotic metabolites from biological fluids using flow injection analysis high-resolution mass spectrometry and post-acquisition data filtering.Metabolome searcher: a high throughput tool for metabolite identification and metabolic pathway mapping directly from mass spectrometry and using genome restrictionLC-MS-based metabolomics in drug metabolismProfiling of hepatic clearance pathways of Pittsburgh compound B and human liver cytochrome p450 phenotyping.A Simple, Rapid and Reliable Method to Determine Imipramine and Desipramine in Mouse Serum Using Ultra-High-Performance Liquid Chromatography-Quadrupole-Time-of-Flight Mass Spectrometry.LC-MS-based Metabolomics of Xenobiotic-induced Toxicities.Database searching for structural identification of metabolites in complex biofluids for mass spectrometry-based metabonomics.From known knowns to known unknowns: predicting in vivo drug metabolites.Peptide and protein drug analysis by MS: challenges and opportunities for the discovery environment.From definition to implementation: a cross-industry perspective of past, current and future MIST strategies.Drug metabolite profiling and identification by high-resolution mass spectrometry.Using high-resolution quadrupole TOF technology in DMPK analyses.Recent advances in metabolite identification and quantitative bioanalysis by LC-Q-TOF MS.Software automation tools for increased throughput metabolic soft-spot identification in early drug discovery.Applications of mass spectrometry in drug metabolism: 50 years of progress.Integration of microfluidic LC with HRMS for the analysis of analytes in biofluids: past, present and future.In vivo drug metabolite identification in preclinical ADME studies by means of UPLC/TWIMS/high resolution-QTOF MS(E) and control comparison: cost and benefit of vehicle-dosed control samples.Systematic and comprehensive strategy for metabolite profiling in bioanalysis using software-assisted HPLC-Q-TOF: magnoflorine as an example.Identification of the major metabolites of quinocetone in swine urine using ultra-performance liquid chromatography/electrospray ionization quadrupole time-of-flight tandem mass spectrometry.A tutorial in small molecule identification via electrospray ionization-mass spectrometry: The practical art of structural elucidation.Identification of metabolites of Radix Paeoniae Alba extract in rat bile, plasma and urine by ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry.In vitro metabolite identification of ML3403, a 4-pyridinylimidazole-type p38 MAP kinase inhibitor by LC-Qq-TOF-MS and LC-SPE-cryo-NMR/MS.Activity-based exposure comparisons among humans and nonclinical safety testing species in an extensively metabolized drug candidate.
P2860
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P2860
Accelerated throughput metabolic route screening in early drug discovery using high-resolution liquid chromatography/quadrupole time-of-flight mass spectrometry and automated data analysis.
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Accelerated throughput metabol ...... y and automated data analysis.
@ast
Accelerated throughput metabol ...... y and automated data analysis.
@en
type
label
Accelerated throughput metabol ...... y and automated data analysis.
@ast
Accelerated throughput metabol ...... y and automated data analysis.
@en
prefLabel
Accelerated throughput metabol ...... y and automated data analysis.
@ast
Accelerated throughput metabol ...... y and automated data analysis.
@en
P2093
P921
P356
P1476
Accelerated throughput metabol ...... y and automated data analysis.
@en
P2093
Desmond O'Connor
Jane Kirby
Jose M Castro-Perez
Russell J Mortishire-Smith
P304
P356
10.1002/RCM.2111
P577
2005-01-01T00:00:00Z