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The pyruvate dehydrogenase complex as a therapeutic target for age-related diseases.

The pyruvate dehydrogenase complex as a therapeutic target for age-related diseases.

http://www.wikidata.org/entity/Q37982890

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Effects of Oxidative Stress on Mesenchymal Stem Cell Biology Pre-symptomatic activation of antioxidant responses and alterations in glucose and pyruvate metabolism in Niemann-Pick Type C1-deficient murine brain Mitochondrial pyruvate carrier 2 hypomorphism in mice leads to defects in glucose-stimulated insulin secretion Increased mitochondrial activity in renal proximal tubule cells from young spontaneously hypertensive rats MicroRNA-26a regulates glucose metabolism by direct targeting PDHX in colorectal cancer cells.Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors.Differing roles of pyruvate dehydrogenase kinases during mouse oocyte maturation.Novel Agents for the Treatment of Type 2 Diabetes.White Matter Lipids as a Ketogenic Fuel Supply in Aging Female Brain: Implications for Alzheimer's Disease.Pyruvate Dehydrogenase Kinases in the Nervous System: Their Principal Functions in Neuronal-glial Metabolic Interaction and Neuro-metabolic Disorders.MicroRNA-15b regulates mitochondrial ROS production and the senescence-associated secretory phenotype through sirtuin 4/SIRT4 Comparative gene expression and phenotype analyses of skeletal muscle from aged wild-type and PAPP-A-deficient mice.Roles of sirtuins in the regulation of antioxidant defense and bioenergetic function of mitochondria under oxidative stress.Epigenetic Treatment of Neurodegenerative Disorders: Alzheimer and Parkinson Diseases.The role of microRNA-26a in human cancer progression and clinical application.The Pancreatic β-Cell: A Bioenergetic Perspective.Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1.Bioprotective carnitinoids: lipoic acid, butyrate, and mitochondria-targeting to treat radiation injury: mitochondrial drugs come of age.SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells.Microarray analysis of Drosophila dicer-2 mutants reveals potential regulation of mitochondrial metabolism by endogenous siRNAs.Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer.Metformin regulates metabolic and nonmetabolic pathways in skeletal muscle and subcutaneous adipose tissues of older adults.Targeting thiamine-dependent enzymes for metabolic therapies in oral squamous cell carcinoma?How phosphorylation influences E1 subunit pyruvate dehydrogenase: A computational study Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism Pyruvate dehydrogenase complex stimulation promotes immunometabolic homeostasis and sepsis survival

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The pyruvate dehydrogenase complex as a therapeutic target for age-related diseases.

http://www.wikidata.org/entity/Q37982890

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article científic

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article scientifique

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artigo científico

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artigo científico

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artigo científico

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artikel ilmiah

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artículo científico

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name

The pyruvate dehydrogenase complex as a therapeutic target for age-related diseases.

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The pyruvate dehydrogenase complex as a therapeutic target for age-related diseases.

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type

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The pyruvate dehydrogenase complex as a therapeutic target for age-related diseases.

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The pyruvate dehydrogenase complex as a therapeutic target for age-related diseases.

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The pyruvate dehydrogenase complex as a therapeutic target for age-related diseases.

@en

The pyruvate dehydrogenase complex as a therapeutic target for age-related diseases.

@nl

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J.1474-9726.2012.00805.X

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The pyruvate dehydrogenase complex as a therapeutic target for age-related diseases.

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Peter W Stacpoole

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P2860

Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism

Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells

Pivotal role of the C-terminal DW-motif in mediating inhibition of pyruvate dehydrogenase kinase 2 by dichloroacetate

Chronic CSE treatment induces the growth of normal oral keratinocytes via PDK2 upregulation, increased glycolysis and HIF1α stabilization

Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex

The remarkable structural and functional organization of the eukaryotic pyruvate dehydrogenase complexes

Altered brain mitochondrial metabolism in healthy aging as assessed by in vivo magnetic resonance spectroscopy

Structural insight into interactions between dihydrolipoamide dehydrogenase (E3) and E3 binding protein of human pyruvate dehydrogenase complex

Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ ) deposition

Regional aerobic glycolysis in the human brain

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