Biochemistry and cell biology of tau protein in neurofibrillary degeneration
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Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastinHsp90-Tau complex reveals molecular basis for specificity in chaperone actionGlial Tau Pathology in Tauopathies: Functional ConsequencesImplications of GABAergic Neurotransmission in Alzheimer's DiseaseThe Metamorphic Nature of the Tau Protein: Dynamic Flexibility Comes at a CostFrontotemporal lobar degeneration: old knowledge and new insight into the pathogenetic mechanisms of tau mutationsMisframed ubiquitin and impaired protein quality control: an early event in Alzheimer's diseasePhysicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)Behavioral assays with mouse models of Alzheimer's disease: practical considerations and guidelines.Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy modelCritical role of acetylation in tau-mediated neurodegeneration and cognitive deficitsAntibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathyAge-dependent neuroinflammation and cognitive decline in a novel Ala152Thr-Tau transgenic mouse model of PSP and AD.Tau physiology and pathomechanisms in frontotemporal lobar degenerationFunction and regulation of tau conformations in the development and treatment of traumatic brain injury and neurodegenerationACAT1/SOAT1 as a therapeutic target for Alzheimer's diseaseThe preclinical phase of the pathological process underlying sporadic Alzheimer's diseaseThe emerging role of peptidyl-prolyl isomerase chaperones in tau oligomerization, amyloid processing, and Alzheimer's diseaseChronic effects of mild neurotrauma: putting the cart before the horse?The release and trans-synaptic transmission of Tau via exosomesThe homologous carboxyl-terminal domains of microtubule-associated protein 2 and TAU induce neuronal dysfunction and have differential fates in the evolution of neurofibrillary tanglesFrontotemporal Dementia.Selective activators of protein phosphatase 5 target the auto-inhibitory mechanism.Histone deacetylase 6 inhibition improves memory and reduces total tau levels in a mouse model of tau deposition.EB1, p150Glued, and Clasp1 control endothelial tubulogenesis through microtubule assembly, acetylation, and apical polarizationImmunophilin FKBP52 induces Tau-P301L filamentous assembly in vitro and modulates its activity in a model of tauopathy.Andrographolide reduces cognitive impairment in young and mature AβPPswe/PS-1 miceHigh copy wildtype human 1N4R tau expression promotes early pathological tauopathy accompanied by cognitive deficits without progressive neurofibrillary degenerationHydration water mobility is enhanced around tau amyloid fibers.Roles of tau protein in health and disease.Immunological memory to hyperphosphorylated tau in asymptomatic individuals."It Ain't Over 'til It's Over" (a) -The Search for Treatments and Cures for Alzheimer's DiseaseTau mutants bind tubulin heterodimers with enhanced affinity.Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 miceMARK4 and MARK3 associate with early tau phosphorylation in Alzheimer's disease granulovacuolar degeneration bodies.Cellular levels of Grb2 and cytoskeleton stability are correlated in a neurodegenerative scenario.Acetylation: a new key to unlock tau's role in neurodegenerationOligomeric tau-targeted immunotherapy in Tg4510 mice.Genetic suppression of β2-adrenergic receptors ameliorates tau pathology in a mouse model of tauopathies.Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L mice
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Biochemistry and cell biology of tau protein in neurofibrillary degeneration
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
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artículo científico
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name
Biochemistry and cell biology of tau protein in neurofibrillary degeneration
@en
type
label
Biochemistry and cell biology of tau protein in neurofibrillary degeneration
@en
prefLabel
Biochemistry and cell biology of tau protein in neurofibrillary degeneration
@en
P2860
P1476
Biochemistry and cell biology of tau protein in neurofibrillary degeneration
@en
P2860
P304
P356
10.1101/CSHPERSPECT.A006247
P577
2012-07-01T00:00:00Z