Lysosome-dependent pathways as a unifying theme in Parkinson's disease.
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Glucocerebrosidase is shaking up the synucleinopathiesCellular function and pathological role of ATP13A2 and related P-type transport ATPases in Parkinson's disease and other neurological disordersGlucocerebrosidase and Parkinson disease: Recent advancesTreating Parkinson's disease in the 21st century: can stem cell transplantation compete?Alpha-synuclein induces lysosomal rupture and cathepsin dependent reactive oxygen species following endocytosisNiemann-Pick C disease gene mutations and age-related neurodegenerative disordersLysosomal Re-acidification Prevents Lysosphingolipid-Induced Lysosomal Impairment and Cellular ToxicityQuantitative proteomic analysis of Parkin substrates in Drosophila neurons.High expression levels of the D686N Parkinson's disease mutation in VPS35 induces α-synuclein-dependent toxicity in yeastMutations in the ATP13A2 gene and Parkinsonism: a preliminary review.The pallidopyramidal syndromes: nosology, aetiology and pathogenesis.Function and dysfunction of two-pore channels.Synaptojanin 1 is required for endolysosomal trafficking of synaptic proteins in cone photoreceptor inner segments.ATP6V0C knockdown in neuroblastoma cells alters autophagy-lysosome pathway function and metabolism of proteins that accumulate in neurodegenerative disease.Can the disease course in Parkinson's disease be slowed?Integrated analysis of genetic, behavioral, and biochemical data implicates neural stem cell-induced changes in immunity, neurotransmission and mitochondrial function in Dementia with Lewy Body mice.ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons.Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease.Silencing synuclein at the synapse with PLK2Lysosomal impairment in Parkinson's disease.Glucosylceramide synthase inhibition alleviates aberrations in synucleinopathy models.Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease.Progress and potential of non-inhibitory small molecule chaperones for the treatment of Gaucher disease and its implications for Parkinson disease.The VPS35 gene and Parkinson's disease.Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies.Animal models of Parkinson's disease: a gateway to therapeutics?Defective autophagy in Parkinson's disease: lessons from genetics.Mechanism and Regulation of Autophagy and Its Role in Neuronal Diseases.Neuropathology of α-synuclein propagation and braak hypothesis.Targeting the Autophagy/Lysosomal Degradation Pathway in Parkinson's Disease.Parkinson's disease: acid-glucocerebrosidase activity and alpha-synuclein clearance.Endocytic vesicle rupture is a conserved mechanism of cellular invasion by amyloid proteins.LRRK2 and Autophagy.A switchable peptide sensor for real-time lysosomal tracking.The Role of Astrocyte Dysfunction in Parkinson's Disease Pathogenesis.Neuroprotective Effects of Paeoniflorin on 6-OHDA-Lesioned Rat Model of Parkinson's Disease.Identification of distinct circulating exosomes in Parkinson's diseaseThe Coordinated Action of Calcineurin and Cathepsin D Protects Against α-Synuclein Toxicity.Surfactant secretion in LRRK2 knock-out rats: changes in lamellar body morphology and rate of exocytosis.A Critical Assessment of Exosomes in the Pathogenesis and Stratification of Parkinson's Disease.
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Lysosome-dependent pathways as a unifying theme in Parkinson's disease.
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
Lysosome-dependent pathways as a unifying theme in Parkinson's disease.
@en
type
label
Lysosome-dependent pathways as a unifying theme in Parkinson's disease.
@en
prefLabel
Lysosome-dependent pathways as a unifying theme in Parkinson's disease.
@en
P2860
P356
P1433
P1476
Lysosome-dependent pathways as a unifying theme in Parkinson's disease
@en
P2093
George K Tofaris
P2860
P304
P356
10.1002/MDS.25136
P407
P577
2012-08-23T00:00:00Z