Aicardi-Goutières syndrome: a model disease for systemic autoimmunity. - Wikidata - wikimedia - TriplyDB

Aicardi-Goutières syndrome: a model disease for systemic autoimmunity.

Aicardi-Goutières syndrome: a model disease for systemic autoimmunity.

http://www.wikidata.org/entity/Q38115813

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Out of balance: R-loops in human disease Identification of Candidate Predictors of Lupus Flare Type I interferon in the pathogenesis of lupus.SAMHD1 prevents autoimmunity by maintaining genome stability.Targeting of type I interferon in systemic autoimmune diseases Defective removal of ribonucleotides from DNA promotes systemic autoimmunity.AGS, SLE, and RNASEH2 mutations: translating insights into therapeutic advances AIM2 Drives Joint Inflammation in a Self-DNA Triggered Model of Chronic Polyarthritis.Advances in understanding the role of type I interferons in systemic lupus erythematosus.Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations.Cytosolic RNA:DNA hybrids activate the cGAS-STING axis.Genetic cause of immune dysregulation - one gene or two?[Type I interferonopathies. Systemic inflammatory diseases triggered by type I interferons].SAMHD1 Gene Mutations Are Associated with Cerebral Large-Artery Atherosclerosis.Autoimmunity and primary immunodeficiency: two sides of the same coin?Increased RNA Editing May Provide a Source for Autoantigens in Systemic Lupus Erythematosus.Genome-wide association study identifies new susceptibility loci for cutaneous lupus erythematosus.Autosomal dominant IFIH1 gain-of-function mutations cause Aicardi-Goutières syndrome.Cytosolic Genomic DNA functions as a Natural Antisense.

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Aicardi-Goutières syndrome: a model disease for systemic autoimmunity.

http://www.wikidata.org/entity/Q38115813

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Aicardi-Goutières syndrome: a model disease for systemic autoimmunity.

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Aicardi-Goutières syndrome: a model disease for systemic autoimmunity.

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Aicardi-Goutières syndrome: a model disease for systemic autoimmunity.

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Clinical and Experimental Immunology

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Aicardi-Goutières syndrome: a model disease for systemic autoimmunity.

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C Günther

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C Wolf

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M A Lee-Kirsch

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Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases

Epidemiology of systemic lupus erythematosus: a comparison of worldwide disease burden

Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway

SAMHD1 is a nucleic-acid binding protein that is mislocalized due to aicardi-goutières syndrome-associated mutations

Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

The Aicardi-Goutières syndrome (familial, early onset encephalopathy with calcifications of the basal ganglia and chronic cerebrospinal fluid lymphocytosis).

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

Trex1 prevents cell-intrinsic initiation of autoimmunity

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17-24

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10.1111/CEI.12160

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1

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175

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2014-01-01T00:00:00Z

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