Chloride channel expression with the tandem construct of alpha 6-beta 2 GABAA receptor subunit requires a monomeric subunit of alpha 6 or gamma 2.
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International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: classification on the basis of subunit composition, pharmacology, and function. UpdateChannel opening by anesthetics and GABA induces similar changes in the GABAA receptor M2 segmentA novel site on gamma 3 subunits important for assembly of GABA(A) receptorsEvidence for the formation of functionally distinct alphabetagammaepsilon GABA(A) receptorsStoichiometry of expressed alpha(4)beta(2)delta gamma-aminobutyric acid type A receptors depends on the ratio of subunit cDNA transfected.Use of concatemers of ligand-gated ion channel subunits to study mechanisms of steroid potentiation.The Direct Actions of GABA, 2'-Methoxy-6-Methylflavone and General Anaesthetics at β3γ2L GABAA Receptors: Evidence for Receptors with Different Subunit Stoichiometries.Incomplete incorporation of tandem subunits in recombinant neuronal nicotinic receptors.Tandem couture: Cys-loop receptor concatamer insights and caveats.Optimized expression vector for ion channel studies in Xenopus oocytes and mammalian cells using alfalfa mosaic virus.Tandem subunits effectively constrain GABAA receptor stoichiometry and recapitulate receptor kinetics but are insensitive to GABAA receptor-associated protein.Steroid interaction with a single potentiating site is sufficient to modulate GABA-A receptor function.Stoichiometric analysis of the TM2 6' phenylalanine mutation on desensitization in alpha1beta2 and alpha1beta2gamma2 GABA A receptors.Emerging approaches to probing ion channel structure and function.Activation and modulation of concatemeric GABA-A receptors expressed in human embryonic kidney cells.Identification of amino acid residues important for assembly of GABA receptor alpha1 and gamma2 subunits.Detection and binding properties of GABA(A) receptor assembly intermediates.Tyrosine 62 of the gamma-aminobutyric acid type A receptor beta 2 subunit is an important determinant of high affinity agonist binding.Two invariant tryptophans on the alpha1 subunit define domains necessary for GABA(A) receptor assembly.Loose protein packing around the extracellular half of the GABA(A) receptor beta1 subunit M2 channel-lining segment.GABA(A) receptor beta 2 Tyr97 and Leu99 line the GABA-binding site. Insights into mechanisms of agonist and antagonist actions.GABA(A) receptor heterogeneity in histaminergic neurons.Spontaneous cross-link of mutated alpha1 subunits during GABA(A) receptor assembly.Coexistence of two beta subunit isoforms in the same gamma-aminobutyric acid type A receptor.Molecular and pharmacological characterization of native cortical gamma-aminobutyric acidA receptors containing both alpha1 and alpha3 subunits.Electrophysiological evidence for the coexistence of alpha1 and alpha6 subunits in a single functional GABA(A) receptor.A GABAA receptor alpha1 subunit tagged with green fluorescent protein requires a beta subunit for functional surface expression.
P2860
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P2860
Chloride channel expression with the tandem construct of alpha 6-beta 2 GABAA receptor subunit requires a monomeric subunit of alpha 6 or gamma 2.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
@zh-hant
name
Chloride channel expression wi ...... subunit of alpha 6 or gamma 2.
@en
type
label
Chloride channel expression wi ...... subunit of alpha 6 or gamma 2.
@en
prefLabel
Chloride channel expression wi ...... subunit of alpha 6 or gamma 2.
@en
P2093
P2860
P356
P1476
Chloride channel expression wi ...... subunit of alpha 6 or gamma 2.
@en
P2093
P2860
P304
26063-26066
P356
10.1074/JBC.270.44.26063
P407
P577
1995-11-01T00:00:00Z