Steroid interaction with a single potentiating site is sufficient to modulate GABA-A receptor function.
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Molecular mechanisms of antiseizure drug activity at GABAA receptorsChloride channels: often enigmatic, rarely predictable.Kinetic and structural determinants for GABA-A receptor potentiation by neuroactive steroids.A synthetic 18-norsteroid distinguishes between two neuroactive steroid binding sites on GABAA receptorsOccupation of either site for the neurosteroid allopregnanolone potentiates the opening of the GABAA receptor induced from either transmitter binding site.Use of concatemers of ligand-gated ion channel subunits to study mechanisms of steroid potentiation.Neurosteroid analogues. 17. Inverted binding orientations of androsterone enantiomers at the steroid potentiation site on γ-aminobutyric acid type A receptorsTwo etomidate sites in α1β2γ2 γ-aminobutyric acid type A receptors contribute equally and noncooperatively to modulation of channel gating.Agonist-specific conformational changes in the α1-γ2 subunit interface of the GABA A receptor.Characteristics of concatemeric GABA(A) receptors containing α4/δ subunits expressed in Xenopus oocytes.Mapping General Anesthetic Sites in Heteromeric γ-Aminobutyric Acid Type A Receptors Reveals a Potential For Targeting Receptor Subtypes.Activation and modulation of concatemeric GABA-A receptors expressed in human embryonic kidney cells.The sticky issue of neurosteroids and GABA(A) receptors.GABA Type A Receptor Activation in the Allosteric Coagonist Model Framework: Relationship between EC50 and Basal Activity.Propofol is an allosteric agonist with multiple binding sites on concatemeric ternary GABAA receptors.A neurosteroid potentiation site can be moved among GABAA receptor subunits.High constitutive activity accounts for the combination of enhanced direct activation and reduced potentiation in mutated GABAA receptors.
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P2860
Steroid interaction with a single potentiating site is sufficient to modulate GABA-A receptor function.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 28 January 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Steroid interaction with a sin ...... late GABA-A receptor function.
@en
Steroid interaction with a sin ...... late GABA-A receptor function.
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type
label
Steroid interaction with a sin ...... late GABA-A receptor function.
@en
Steroid interaction with a sin ...... late GABA-A receptor function.
@nl
prefLabel
Steroid interaction with a sin ...... late GABA-A receptor function.
@en
Steroid interaction with a sin ...... late GABA-A receptor function.
@nl
P2860
P356
P1476
Steroid interaction with a sin ...... late GABA-A receptor function.
@en
P2093
Joe Henry Steinbach
John R Bracamontes
P2860
P304
P356
10.1124/MOL.108.053629
P577
2009-01-28T00:00:00Z