GABA(A) receptor beta 2 Tyr97 and Leu99 line the GABA-binding site. Insights into mechanisms of agonist and antagonist actions.
about
A unified model of the GABA(A) receptor comprising agonist and benzodiazepine binding sitesActivation of single heteromeric GABA(A) receptor ion channels by full and partial agonistsStructural studies of the actions of anesthetic drugs on the γ-aminobutyric acid type A receptorα4βδ GABA(A) receptors are high-affinity targets for γ-hydroxybutyric acid (GHB)Mapping the rho1 GABA(C) receptor agonist binding pocket. Constructing a complete modelAn Electrostatic Funnel in the GABA-Binding PathwayThe kinetics of competitive antagonism of nicotinic acetylcholine receptors at physiological temperature.Prototypic GABA(A) receptor agonist muscimol acts preferentially through forebrain high-affinity binding sites.New insights into the GABA(A) receptor structure and orthosteric ligand binding: receptor modeling guided by experimental data.Disruption of an intersubunit electrostatic bond is a critical step in glycine receptor activation.Allosteric modulators induce distinct movements at the GABA-binding site interface of the GABA-A receptor.EXP-1 is an excitatory GABA-gated cation channel.Spillover transmission is mediated by the excitatory GABA receptor LGC-35 in C. elegansThree arginines in the GABAA receptor binding pocket have distinct roles in the formation and stability of agonist- versus antagonist-bound complexesA tight coupling between β₂Y97 and β₂F200 of the GABA(A) receptor mediates GABA bindingStructural link between γ-aminobutyric acid type A (GABAA) receptor agonist binding site and inner β-sheet governs channel activation and allosteric drug modulationMultiple tyrosine residues at the GABA binding pocket influence surface expression and mediate kinetics of the GABAA receptorIndividually monitoring ligand-induced changes in the structure of the GABAA receptor at benzodiazepine binding site and non-binding-site interfaces.Unnatural amino acid mutagenesis of the GABA(A) receptor binding site residues reveals a novel cation-pi interaction between GABA and beta 2Tyr97A hydrogen bond in loop A is critical for the binding and function of the 5-HT3 receptor.Competitive antagonists facilitate the recovery from desensitization of α1β2γ2 GABAA receptors expressed in Xenopus oocytesAgonist-dependent endocytosis of γ-aminobutyric acid type A (GABAA) receptors revealed by a γ2(R43Q) epilepsy mutation.Structural rearrangements in loop F of the GABA receptor signal ligand binding, not channel activation.The role of Loop F in the activation of the GABA receptor.Synaptic neurotransmitter-gated receptorsNematode cys-loop GABA receptors: biological function, pharmacology and sites of action for anthelmintics.Pharmacophore models for GABA(A) modulators: implications in CNS drug discovery.A role for loop G in the β1 strand in GABAA receptor activation.Mapping a molecular link between allosteric inhibition and activation of the glycine receptor.Molecular basis for modulation of recombinant alpha1beta2gamma2 GABAA receptors by protons.On the benzodiazepine binding pocket in GABAA receptors.The role of loop 5 in acetylcholine receptor channel gating.Structural basis for allosteric coupling at the membrane-protein interface in Gloeobacter violaceus ligand-gated ion channel (GLIC).Agonist- and antagonist-induced conformational changes of loop F and their contributions to the rho1 GABA receptor function.Charged residues in the beta2 subunit involved in GABAA receptor activation.Different residues in the GABA(A) receptor alpha 1T60-alpha 1K70 region mediate GABA and SR-95531 actions.The GABAA receptor alpha 1 subunit Pro174-Asp191 segment is involved in GABA binding and channel gating.Functional and structural analysis of the GABAA receptor alpha 1 subunit during channel gating and alcohol modulation.Conformational changes at benzodiazepine binding sites of GABA(A) receptors detected with a novel technique.Sites in TM2 and 3 are critical for alcohol-induced conformational changes in GABA receptors.
P2860
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P2860
GABA(A) receptor beta 2 Tyr97 and Leu99 line the GABA-binding site. Insights into mechanisms of agonist and antagonist actions.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
GABA(A) receptor beta 2 Tyr97 ...... gonist and antagonist actions.
@en
type
label
GABA(A) receptor beta 2 Tyr97 ...... gonist and antagonist actions.
@en
prefLabel
GABA(A) receptor beta 2 Tyr97 ...... gonist and antagonist actions.
@en
P2093
P2860
P356
P1476
GABA(A) receptor beta 2 Tyr97 ...... gonist and antagonist actions.
@en
P2093
Andrew J Boileau
Cynthia Czajkowski
J Glen Newell
P2860
P304
P356
10.1074/JBC.M109334200
P407
P577
2001-11-15T00:00:00Z