Microphthalmia transcription factor regulates the expression of the novel osteoclast factor GPNMB.
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Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localizationADAM10 releases a soluble form of the GPNMB/Osteoactivin extracellular domain with angiogenic propertiesThe potential of GPNMB as novel neuroprotective factor in amyotrophic lateral sclerosisFifteen-year quest for microphthalmia-associated transcription factor target genesOsteoactivin is a novel osteoclastic protein and plays a key role in osteoclast differentiation and activitymiRNA-based mechanism for the commitment of multipotent progenitors to a single cellular fate.Iris phenotypes and pigment dispersion caused by genes influencing pigmentation.Targeted overexpression of osteoactivin in cells of osteoclastic lineage promotes osteoclastic resorption and bone loss in mice.The melanoma-associated transmembrane glycoprotein Gpnmb controls trafficking of cellular debris for degradation and is essential for tissue repairSilencing of GPNMB by siRNA inhibits the formation of melanosomes in melanocytes in a MITF-independent fashionComparison of melanoblast expression patterns identifies distinct classes of genesInhibition of Phosphatase Activity Follows Decline in Sulfatase Activity and Leads to Transcriptional Effects through Sustained Phosphorylation of Transcription Factor MITF.The transcription factor MITF is a critical regulator of GPNMB expression in dendritic cells.Mutation in Osteoactivin Promotes Receptor Activator of NFκB Ligand (RANKL)-mediated Osteoclast Differentiation and Survival but Inhibits Osteoclast FunctionGlycoprotein nonmetastatic melanoma protein B extracellular fragment shows neuroprotective effects and activates the PI3K/Akt and MEK/ERK pathways via the Na+/K+-ATPase.Genomic expression analysis of rat chromosome 4 for skeletal traits at femoral neck.The PKD domain distinguishes the trafficking and amyloidogenic properties of the pigment cell protein PMEL and its homologue GPNMB.Glycoprotein non-metastatic b (GPNMB): A metastatic mediator and emerging therapeutic target in cancer.Management of metastatic breast cancer with second-generation antibody-drug conjugates: focus on glembatumumab vedotin (CDX-011, CR011-vcMMAE).Glycoprotein NMB: an Emerging Role in Neurodegenerative Disease.Targeting Glycoprotein NMB With Antibody-Drug Conjugate, Glembatumumab Vedotin, for the Treatment of Osteosarcoma.Differential expression of glycoprotein non-metastatic melanoma protein B (GPNMB) involved in trichostatin A-induced apoptosis in gastric cancer.Redefinition of the human mast cell transcriptome by deep-CAGE sequencingGlycoprotein transmembrane nmb: an androgen-downregulated gene attenuates cell invasion and tumorigenesis in prostate carcinoma cells.The intracellular domain of teneurin-1 induces the activity of microphthalmia-associated transcription factor (MITF) by binding to transcriptional repressor HINT1.GPNMB Induces BiP Expression by Enhancing Splicing of BiP Pre-mRNA during the Endoplasmic Reticulum Stress Response.Two Distinct Myeloid Subsets at the Term Human Fetal-Maternal Interface.Interleukin-22 participates in the inflammatory process of vitiligo.Glycoprotein Non-Metastatic Melanoma Protein B (GPNMB) and Cancer: A Novel Potential Therapeutic Target.Loss of GPNMB Causes Autosomal-Recessive Amyloidosis Cutis Dyschromica in Humans.Glycoprotein nonmetastatic melanoma protein B ameliorates skeletal muscle lesions in a SOD1G93A mouse model of amyotrophic lateral sclerosis.Validating glycoprotein non-metastatic melanoma B (gpNMB, osteoactivin), a new biomarker of Gaucher disease.
P2860
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P2860
Microphthalmia transcription factor regulates the expression of the novel osteoclast factor GPNMB.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Microphthalmia transcription f ...... novel osteoclast factor GPNMB.
@en
type
label
Microphthalmia transcription f ...... novel osteoclast factor GPNMB.
@en
prefLabel
Microphthalmia transcription f ...... novel osteoclast factor GPNMB.
@en
P2093
P50
P1433
P1476
Microphthalmia transcription f ...... novel osteoclast factor GPNMB.
@en
P2093
Liza-Jane Raggatt
Ming K Chang
Nicholas A Meadows
Vera M Ripoll
P356
10.1016/J.GENE.2008.01.014
P407
P577
2008-01-26T00:00:00Z