A mutant form of JAB/SOCS1 augments the cytokine-induced JAK/STAT pathway by accelerating degradation of wild-type JAB/CIS family proteins through the SOCS-box.
about
The E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteinsPrinciples of interleukin (IL)-6-type cytokine signalling and its regulationSOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardationSTAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motifActivation of SOCS-3 by resistinViral exploitation of host SOCS protein functionsRegulation of cytokine receptor signaling by SOCS1.CUEDC2 (CUE domain-containing 2) and SOCS3 (suppressors of cytokine signaling 3) cooperate to negatively regulate Janus kinase 1/signal transducers and activators of transcription 3 signaling.Coreceptor gene imprinting governs thymocyte lineage fate.The SOCS box of suppressor of cytokine signaling-3 contributes to the control of G-CSF responsiveness in vivo.Deletion of the SOCS box of suppressor of cytokine signaling 3 (SOCS3) in embryonic stem cells reveals SOCS box-dependent regulation of JAK but not STAT phosphorylation.Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells.STAT3 and suppressor of cytokine signaling 3: potential targets in lung inflammatory responses.BLNK suppresses pre-B-cell leukemogenesis through inhibition of JAK3.Computational models of the JAK1/2-STAT1 signalingSuppressors of cytokine signaling (SOCS) in T cell differentiation, maturation, and function.SOCS-1 localizes to the microtubule organizing complex-associated 20S proteasome.Suppressors of cytokine signaling: Potential immune checkpoint molecules for cancer immunotherapy.The suppressor of cytokine signaling-1 (SOCS1) is a novel therapeutic target for enterovirus-induced cardiac injuryDivergent mechanisms utilized by SOCS3 to mediate interleukin-10 inhibition of tumor necrosis factor alpha and nitric oxide production by macrophages.SOCS2 can enhance interleukin-2 (IL-2) and IL-3 signaling by accelerating SOCS3 degradation.Role of the cytokine-induced SH2 domain-containing protein CIS in growth hormone receptor internalization.Constitutive SOCS-3 expression protects T-cell lymphoma against growth inhibition by IFNalpha.Suppressor of cytokine signalling-1 gene silencing in acute myeloid leukaemia and human haematopoietic cell lines.Distinct activities of suppressor of cytokine signaling (SOCS) proteins and involvement of the SOCS box in controlling G-CSF signaling.Tyrosine phosphorylation disrupts elongin interaction and accelerates SOCS3 degradation.Roles of STAT3/SOCS3 pathway in regulating the visual function and ubiquitin-proteasome-dependent degradation of rhodopsin during retinal inflammation.Tumor necrosis factor-a augments lipopolysaccharide-induced suppressor of cytokine signalling 3 (SOCS-3) protein expression by preventing the degradation.Control mechanism of JAK/STAT signal transduction pathway.The transcription factor ThPOK suppresses Runx3 and imposes CD4(+) lineage fate by inducing the SOCS suppressors of cytokine signaling.Elongin B/C recruitment regulates substrate binding by CIS.Identification of lineage-specifying cytokines that signal all CD8+-cytotoxic-lineage-fate 'decisions' in the thymus.Timing and duration of MHC I positive selection signals are adjusted in the thymus to prevent lineage errors.
P2860
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P2860
A mutant form of JAB/SOCS1 augments the cytokine-induced JAK/STAT pathway by accelerating degradation of wild-type JAB/CIS family proteins through the SOCS-box.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
A mutant form of JAB/SOCS1 aug ...... proteins through the SOCS-box.
@en
type
label
A mutant form of JAB/SOCS1 aug ...... proteins through the SOCS-box.
@en
prefLabel
A mutant form of JAB/SOCS1 aug ...... proteins through the SOCS-box.
@en
P2093
P2860
P356
P1476
A mutant form of JAB/SOCS1 aug ...... proteins through the SOCS-box
@en
P2093
A Yoshimura
H Yasukawa
S Minoguchi
P2860
P304
40746-40754
P356
10.1074/JBC.M106139200
P407
P577
2001-08-24T00:00:00Z