The LIM-only factor LMO4 regulates expression of the BMP7 gene through an HDAC2-dependent mechanism, and controls cell proliferation and apoptosis of mammary epithelial cells.
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The estrogen-responsive Agr2 gene regulates mammary epithelial proliferation and facilitates lobuloalveolar developmentRegulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancerDownstream targets of Lmo4 are modulated by cisplatin in the inner ear of Wistar ratsLoss of LMO4 in the retina leads to reduction of GABAergic amacrine cells and functional deficits.The co-factor of LIM domains (CLIM/LDB/NLI) maintains basal mammary epithelial stem cells and promotes breast tumorigenesis.Cisplatin-induced ototoxicity is mediated by nitroxidative modification of cochlear proteins characterized by nitration of Lmo4Lmo4 in the basolateral complex of the amygdala modulates fear learningContribution of DEAF1 structural domains to the interaction with the breast cancer oncogene LMO4.The structure of an LIM-only protein 4 (LMO4) and Deformed epidermal autoregulatory factor-1 (DEAF1) complex reveals a common mode of binding to LMO4.Alk is a transcriptional target of LMO4 and ERα that promotes cocaine sensitization and reward.Area-specific development of distinct projection neuron subclasses is regulated by postnatal epigenetic modifications.Aberrant expression of LMO4 induces centrosome amplification and mitotic spindle abnormalities in breast cancer cells.The oncoprotein HBXIP activates transcriptional coregulatory protein LMO4 via Sp1 to promote proliferation of breast cancer cells.LIM only 4 is overexpressed in late stage pancreas cancerTargeting nitrative stress for attenuating cisplatin-induced downregulation of cochlear LIM domain only 4 and ototoxicityLMO4 is a prognostic marker involved in cell migration and invasion in non-small-cell lung cancer.Control of the bone morphogenetic protein 7 gene in developmental and adult life.LIM-domain-only proteins in cancer.LIM-domain-only proteins: multifunctional nuclear transcription coregulators that interacts with diverse proteins.Transcriptional regulation of epidermal barrier formation.Cisplatin-induced apoptosis in auditory, renal, and neuronal cells is associated with nitration and downregulation of LMO4.LMO4 functions as a co-activator of neurogenin 2 in the developing cortex.LMO4 is an essential mediator of ErbB2/HER2/Neu-induced breast cancer cell cycle progression.The LIM adaptor protein LMO4 is an essential regulator of neural crest development.LIM domain only 4 protein promotes granulocyte colony-stimulating factor-induced signaling in neurons.LMO4 modulates proliferation and differentiation of 3T3-L1 preadipocytes.Suppression of BMP-7 by histone deacetylase 2 promoted apoptosis of renal tubular epithelial cells in acute kidney injury.CRISPR/Cas9-mediated knockout of Lim-domain only four retards organ of Corti cell growth.
P2860
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P2860
The LIM-only factor LMO4 regulates expression of the BMP7 gene through an HDAC2-dependent mechanism, and controls cell proliferation and apoptosis of mammary epithelial cells.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
The LIM-only factor LMO4 regul ...... s of mammary epithelial cells.
@en
type
label
The LIM-only factor LMO4 regul ...... s of mammary epithelial cells.
@en
prefLabel
The LIM-only factor LMO4 regul ...... s of mammary epithelial cells.
@en
P2093
P2860
P356
P1433
P1476
The LIM-only factor LMO4 regul ...... s of mammary epithelial cells.
@en
P2093
Andersen B
P2860
P2888
P304
P356
10.1038/SJ.ONC.1210465
P407
P577
2007-04-23T00:00:00Z
P5875
P6179
1019943747