Probing the structure-activity relationship of Escherichia coli LT-A by site-directed mutagenesis.
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NAD binding induces conformational changes in Rho ADP-ribosylating clostridium botulinum C3 exoenzymeAttenuated Shigella flexneri 2a vaccine strain CVD 1204 expressing colonization factor antigen I and mutant heat-labile enterotoxin of enterotoxigenic Escherichia coli.Antipeptide antibody responses following intranasal immunization: effectiveness of mucosal adjuvants.Mucosal adjuvant properties of mutant LT-IIa and LT-IIb enterotoxins that exhibit altered ganglioside-binding activities.Levels of expression and immunogenicity of attenuated Salmonella enterica serovar typhimurium strains expressing Escherichia coli mutant heat-labile enterotoxinInhibition of class II major histocompatibility complex antigen processing by Escherichia coli heat-labile enterotoxin requires an enzymatically active A subunitProtective mucosal immunity to ocular herpes simplex virus type 1 infection in mice by using Escherichia coli heat-labile enterotoxin B subunit as an adjuvant.The immune responses to bacterial antigens encountered in vivo at mucosal surfaces.Biological and biochemical characterization of variant A subunits of cholera toxin constructed by site-directed mutagenesis.Oral administration of influenza vaccine in combination with the adjuvants LT-K63 and LT-R72 induces potent immune responses comparable to or stronger than traditional intramuscular immunizationEffects of site-directed mutagenesis of Escherichia coli heat-labile enterotoxin on ADP-ribosyltransferase activity and interaction with ADP-ribosylation factors.In vivo expression and immunoadjuvancy of a mutant of heat-labile enterotoxin of Escherichia coli in vaccine and vector strains of Vibrio choleraeIntranasal immunization of mice with influenza vaccine in combination with the adjuvant LT-R72 induces potent mucosal and serum immunity which is stronger than that with traditional intramuscular immunization.Native and mutant forms of cholera toxin and heat-labile enterotoxin effectively enhance protective efficacy of live attenuated and heat-killed Shigella vaccines.Intranasal immunization with pneumococcal polysaccharide conjugate vaccines with nontoxic mutants of Escherichia coli heat-labile enterotoxins as adjuvants protects mice against invasive pneumococcal infections.Intranasal immunization with SAG1 and nontoxic mutant heat-labile enterotoxins protects mice against Toxoplasma gondii.A revisit of mucosal IgA immunity and oral tolerance.Functional diversity of heat-labile toxins (LT) produced by enterotoxigenic Escherichia coli: differential enzymatic and immunological activities of LT1 (hLT) AND LT4 (pLT)Mutants of the Escherichia coli heat-labile enterotoxin as safe and strong adjuvants for intranasal delivery of vaccines.A mutational analysis of residues in cholera toxin A1 necessary for interaction with its substrate, the stimulatory G protein Gsα.Induction of antigen-specific antibodies in vaginal secretions by using a nontoxic mutant of heat-labile enterotoxin as a mucosal adjuvantIntranasal immunogenicity and adjuvanticity of site-directed mutant derivatives of cholera toxin.Mucosal adjuvants and delivery systems for protein-, DNA- and RNA-based vaccines.A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity.Parenteral Adjuvant Effects of an Enterotoxigenic Escherichia coli Natural Heat-Labile Toxin VariantHeat-labile enterotoxins as adjuvants or anti-inflammatory agents.Bioadhesive delivery systems for mucosal vaccine delivery.Recent advances in nontoxic Escherichia coli heat-labile toxin and its derivative adjuvants.Safety and immunogenicity of bacterial and tobacco plant cell line derived recombinant native and mutant Escherichia coli heat-labile toxin in chickens.New method to generate enzymatically deficient Clostridium difficile toxin B as an antigen for immunizationDissociation of Escherichia coli heat-labile enterotoxin adjuvanticity from ADP-ribosyltransferase activity.Construction of nontoxic derivatives of cholera toxin and characterization of the immunological response against the A subunit.Mutations in the A subunit affect yield, stability, and protease sensitivity of nontoxic derivatives of heat-labile enterotoxin.Protease susceptibility and toxicity of heat-labile enterotoxins with a mutation in the active site or in the protease-sensitive loop.Genetically detoxified mutants of heat-labile enterotoxin from Escherichia coli are effective adjuvants for induction of cytotoxic T-cell responses against HIV-1 gag-p55.A genetically detoxified derivative of heat-labile Escherichia coli enterotoxin induces neutralizing antibodies against the A subunit.Mucosal adjuvanticity and immunogenicity of LTR72, a novel mutant of Escherichia coli heat-labile enterotoxin with partial knockout of ADP-ribosyltransferase activity.Crystal structure of a non-toxic mutant of heat-labile enterotoxin, which is a potent mucosal adjuvant.Intranasal immunization of mice with herpes simplex virus type 2 recombinant gD2: the effect of adjuvants on mucosal and serum antibody responses.A novel concept in mucosal adjuvanticity: the CTA1-DD adjuvant is a B cell-targeted fusion protein that incorporates the enzymatically active cholera toxin A1 subunit.
P2860
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P2860
Probing the structure-activity relationship of Escherichia coli LT-A by site-directed mutagenesis.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Probing the structure-activity ...... by site-directed mutagenesis.
@en
type
label
Probing the structure-activity ...... by site-directed mutagenesis.
@en
prefLabel
Probing the structure-activity ...... by site-directed mutagenesis.
@en
P2093
P2860
P1476
Probing the structure-activity ...... A by site-directed mutagenesis
@en
P2093
C Magagnoli
M Domenighini
M M Giuliani
M R Fontana
R Rappuoli
V Giannelli
P2860
P356
10.1111/J.1365-2958.1994.TB01266.X
P407
P577
1994-10-01T00:00:00Z